Antoni P. A. Hendrickx
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View article: Attributable sources of the five most prevalent non-typhoidal Salmonella serovars across ten European countries
Attributable sources of the five most prevalent non-typhoidal Salmonella serovars across ten European countries Open
Non-typhoidal Salmonella is the second most frequently reported zoonotic pathogen in the European Union and European Economic Area. Most human infections are caused by serovars Enteritidis and Typhimurium. Genomic characterisation of Salmo…
View article: Recurring acquisition of carbapenemase genes and global emergence of <i>Pseudomonas aeruginosa</i> ST-1047, a lineage shaped by geopolitical conflicts
Recurring acquisition of carbapenemase genes and global emergence of <i>Pseudomonas aeruginosa</i> ST-1047, a lineage shaped by geopolitical conflicts Open
Pseudomonas aeruginosa sequence type (ST)-1047 is emerging globally as a carbapenemase-rich lineage, yet its evolutionary history and population structure are not known. Here, we performed a comprehensive genomic and epidemiological invest…
View article: Cross-border spread of a mosaic resistance (OXA-48) and virulence (aerobactin) plasmid in Klebsiella pneumoniae: a European Antimicrobial Resistance Genes Surveillance Network investigation, Europe, February 2019 to October 2024
Cross-border spread of a mosaic resistance (OXA-48) and virulence (aerobactin) plasmid in Klebsiella pneumoniae: a European Antimicrobial Resistance Genes Surveillance Network investigation, Europe, February 2019 to October 2024 Open
An investigation of the European Antimicrobial Resistance Genes Surveillance Network (EURGen-Net) detected the same mosaic IncHI1B(pNDM-MAR) resistance (OXA-48) and virulence (aerobactin) plasmid in 492 Klebsiella pneumoniae isolates from …
View article: Aquatic reservoir-associated outbreaks of multi-drug-resistant bacteria: a hospital outbreak report of Pseudomonas aeruginosa in perspective from the Dutch national surveillance databases
Aquatic reservoir-associated outbreaks of multi-drug-resistant bacteria: a hospital outbreak report of Pseudomonas aeruginosa in perspective from the Dutch national surveillance databases Open
View article: Healthcare professionals challenged by 14 distinct carbapenemase-producing micro-organisms in a war-injured Ukrainian patient
Healthcare professionals challenged by 14 distinct carbapenemase-producing micro-organisms in a war-injured Ukrainian patient Open
The Russia-Ukraine war lead to evacuation of patients across Europe. We present an unprecedented case of a severely injured Ukrainian soldier carrying 11 carbapenemase-producing Enterobacterales, two carbapenemase-producing Pseudomonas aer…
View article: Methicillin-resistant Staphylococcus aureus GG0398 on livestock farms and meat in the Netherlands
Methicillin-resistant Staphylococcus aureus GG0398 on livestock farms and meat in the Netherlands Open
View article: Outer membrane vesicles of carbapenem-resistant clinical Acinetobacter baumannii isolates protect both the vesicle-producing bacteria and non-resistant bacteria against carbapenems
Outer membrane vesicles of carbapenem-resistant clinical Acinetobacter baumannii isolates protect both the vesicle-producing bacteria and non-resistant bacteria against carbapenems Open
Infections caused by carbapenem-resistant Acinetobacter baumannii (A. baumannii; CRAb) are associated with high patient morbidity and mortality. The serious threat for human health imposed by CRAb was recently underscored by identification…
View article: Diversification of bla OXA-48-harbouring plasmids among carbapenemase-producing Enterobacterales, 11 years after a large outbreak in a general hospital in the Netherlands
Diversification of bla OXA-48-harbouring plasmids among carbapenemase-producing Enterobacterales, 11 years after a large outbreak in a general hospital in the Netherlands Open
Introduction. Genes encoding OXA-48-like carbapenem-hydrolyzing enzymes are often located on plasmids and are abundant among carbapenemase-producing Enterobacterales (CPE) worldwide. After a large bla OXA-48 plasmid-mediated outbreak in 20…
View article: Nosocomial transmission of NDM-1-containing Klebsiella pneumoniae ST147 in a Dutch pediatric oncology center associated with patients from Ukraine
Nosocomial transmission of NDM-1-containing Klebsiella pneumoniae ST147 in a Dutch pediatric oncology center associated with patients from Ukraine Open
View article: Genomic surveillance of multidrug-resistant organisms based on long-read sequencing
Genomic surveillance of multidrug-resistant organisms based on long-read sequencing Open
We demonstrate that molecular characterization of automatically extracted DNA followed by long-read sequencing is as accurate compared to short-read sequencing and suitable for typing and outbreak analysis as part of genomic surveillance o…
View article: Emergence of Escherichia coli ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024
Emergence of Escherichia coli ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024 Open
Analysis of 594 isolates of Escherichia coli sequence type (ST)131 and its single locus variants carrying carbapenemase genes from 17 European Union/European Economic Area countries revealed acquisition of 18 carbapenemase variants, mainly…
View article: Genomic surveillance detects interregional spread of New Delhi metallo-beta-lactamase-1-producing Providencia stuartii in hospitals, Romania, December 2021 to September 2023
Genomic surveillance detects interregional spread of New Delhi metallo-beta-lactamase-1-producing Providencia stuartii in hospitals, Romania, December 2021 to September 2023 Open
Background New Delhi metallo-beta-lactamase (NDM)-producing Providencia stuartii has been reported from European Union/European Economic Area (EU/EEA) countries with increasing frequency. During 2018 to 2022, 355 cases of NDM-producing P. …
View article: Management of vancomycin-resistant Enterococcus faecium in Dutch healthcare institutes: a nationwide survey
Management of vancomycin-resistant Enterococcus faecium in Dutch healthcare institutes: a nationwide survey Open
View article: Emergence of OXA-48 carbapenemase-producing Salmonella enterica in the Netherlands, 2023
Emergence of OXA-48 carbapenemase-producing Salmonella enterica in the Netherlands, 2023 Open
View article: Antimicrobial susceptibility to last-resort antibiotics in carbapenemase-producing bacteria from Ukrainian patients
Antimicrobial susceptibility to last-resort antibiotics in carbapenemase-producing bacteria from Ukrainian patients Open
Since March 2022, an increase was observed in multidrug-resistant microorganisms (MDRO), associated with the hospital transfer of Ukrainian patients. The goal was to collect phenotypic susceptibility data and assess clinical implications. …
View article: Tracing the origin of NDM-1-producing and extensively drug-resistant Pseudomonas aeruginosa ST357 in the Netherlands
Tracing the origin of NDM-1-producing and extensively drug-resistant Pseudomonas aeruginosa ST357 in the Netherlands Open
This study presents an extensively-drug resistant subclone of NDM-producing P. aeruginosa ST357 with a unique resistome which was introduced to the Netherlands via repatriation of critically ill patients from Kenya. Therefore, the monitori…
View article: Simultaneous clonal spread of NDM-1–producing Pseudomonas aeruginosa ST773 from Ukrainian patients in the Netherlands and Spain
Simultaneous clonal spread of NDM-1–producing Pseudomonas aeruginosa ST773 from Ukrainian patients in the Netherlands and Spain Open
We report a clonal dissemination of NDM-producing P. aeruginosa ST773 to the Netherlands and Spain associated with patients from Ukraine. Our work highlights the importance of genomic surveillance and to understand the dynamics of r…
View article: Nosocomial transmission of tet(x3), blaNDM-1 and blaOXA-97-carrying Acinetobacter baumannii conferring resistance to eravacycline and omadacycline, the Netherlands, March to August 2021
Nosocomial transmission of tet(x3), blaNDM-1 and blaOXA-97-carrying Acinetobacter baumannii conferring resistance to eravacycline and omadacycline, the Netherlands, March to August 2021 Open
Carbapenem-resistant Acinetobacter baumannii (CRAb) is an important pathogen causing serious nosocomial infections. We describe an outbreak of CRAb in an intensive care unit in the Netherlands in 2021. During an outbreak of non-resistant A…
View article: KPC-85, a carbapenemase-producing and ceftazidime-avibactam-resistant KPC-3 variant found in Klebsiella pneumoniae ST512 in the Netherlands
KPC-85, a carbapenemase-producing and ceftazidime-avibactam-resistant KPC-3 variant found in Klebsiella pneumoniae ST512 in the Netherlands Open
View article: Dissemination of extensively drug-resistant NDM-producing Providencia stuartii in Europe linked to patients transferred from Ukraine, March 2022 to March 2023
Dissemination of extensively drug-resistant NDM-producing Providencia stuartii in Europe linked to patients transferred from Ukraine, March 2022 to March 2023 Open
Background The war in Ukraine led to migration of Ukrainian people. Early 2022, several European national surveillance systems detected multidrug-resistant (MDR) bacteria related to Ukrainian patients. Aim To investigate the genomic epidem…
View article: Spread of carbapenemase-producing Morganella spp from 2013 to 2021: a comparative genomic study
Spread of carbapenemase-producing Morganella spp from 2013 to 2021: a comparative genomic study Open
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View article: Antimicrobial susceptibility profile of clinically relevant<i>Bacteroides</i>,<i>Phocaeicola</i>,<i>Parabacteroides</i>and<i>Prevotella</i>species, isolated by eight laboratories in the Netherlands
Antimicrobial susceptibility profile of clinically relevant<i>Bacteroides</i>,<i>Phocaeicola</i>,<i>Parabacteroides</i>and<i>Prevotella</i>species, isolated by eight laboratories in the Netherlands Open
Objectives Recently, reports on antimicrobial-resistant Bacteroides and Prevotella isolates have increased in the Netherlands. This urged the need for a surveillance study on the antimicrobial susceptibility profile of Bacteroides, Phocaei…
View article: Colonization of vancomycin-resistant <i>Enterococcus faecium</i> in human-derived colonic epithelium: unraveling the transcriptional dynamics of host–enterococcal interactions
Colonization of vancomycin-resistant <i>Enterococcus faecium</i> in human-derived colonic epithelium: unraveling the transcriptional dynamics of host–enterococcal interactions Open
Enterococcus faecium is an opportunistic pathogen able to colonize the intestines of hospitalized patients. This initial colonization is an important step in the downstream pathogenesis, which includes outgrowth of the intestinal microbiot…
View article: YajC, a predicted membrane protein, promotes <i>Enterococcus faecium</i> biofilm formation <i>in vitro</i> and in a rat endocarditis model
YajC, a predicted membrane protein, promotes <i>Enterococcus faecium</i> biofilm formation <i>in vitro</i> and in a rat endocarditis model Open
Biofilm formation is a critical step in the pathogenesis of difficult-to-treat Gram-positive bacterial infections. We identified that YajC, a conserved membrane protein in bacteria, plays a role in biofilm formation of the clinically relev…
View article: O03 Phenotypic antimicrobial resistance to last-resort antibiotics in carbapenemase-producing bacteria from Ukrainian patients
O03 Phenotypic antimicrobial resistance to last-resort antibiotics in carbapenemase-producing bacteria from Ukrainian patients Open
Background Since March 2022, there has been an emergence of MDR microorganisms (MDRO) in Europe because of an increasing number of Ukrainian patients with MDRO. The goal was to collect large-scale phenotypic susceptibility data to assess i…
View article: Horizontal gene transfer of a cfiA element between two different Bacteroides species within a clinical specimen
Horizontal gene transfer of a cfiA element between two different Bacteroides species within a clinical specimen Open
View article: OXA-48–Producing Uropathogenic <i>Escherichia coli</i> Sequence Type 127, the Netherlands, 2015–2022
OXA-48–Producing Uropathogenic <i>Escherichia coli</i> Sequence Type 127, the Netherlands, 2015–2022 Open
During 2015-2022, a genetic cluster of OXA-48-producing uropathogenic Escherichia coli sequence type 127 spread throughout the Netherlands. The 20 isolates we investigated originated mainly from urine, belonged to Clermont phylotype B2, an…
View article: Molecular characterization of MRSA collected during national surveillance between 2008 and 2019 in the Netherlands
Molecular characterization of MRSA collected during national surveillance between 2008 and 2019 in the Netherlands Open
View article: Widespread Detection of Yersiniabactin Gene Cluster and Its Encoding Integrative Conjugative Elements (ICE <i>Kp</i> ) among Nonoutbreak OXA-48-Producing <i>Klebsiella pneumoniae</i> Clinical Isolates from Spain and the Netherlands
Widespread Detection of Yersiniabactin Gene Cluster and Its Encoding Integrative Conjugative Elements (ICE <i>Kp</i> ) among Nonoutbreak OXA-48-Producing <i>Klebsiella pneumoniae</i> Clinical Isolates from Spain and the Netherlands Open
Convergence of multidrug resistance and hypervirulence in Klebsiella pneumoniae isolates has been reported mostly related to sporadic cases or small outbreaks. Nevertheless, little is known about the real prevalence of carbapenem-resistant…
View article: Markers of epidemiological success of methicillin-resistant Staphylococcus aureus isolates in European populations
Markers of epidemiological success of methicillin-resistant Staphylococcus aureus isolates in European populations Open