Antonia Koutsoukou
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View article: Time-Trend Analysis of Low Birthweight in Greece: Mapping a Heavy Public Health Burden
Time-Trend Analysis of Low Birthweight in Greece: Mapping a Heavy Public Health Burden Open
During 1980-2023, the LBWR increased by 80%, with significant rising trends in the 1990s and 2000s, resulting in Greece having the highest rates among high-income countries. Whereas the overall LBWR has stabilized since 2010, there has bee…
View article: Nebulized aminoglycosides for ventilator-associated pneumonia: Methodological considerations and lessons from experimental studies
Nebulized aminoglycosides for ventilator-associated pneumonia: Methodological considerations and lessons from experimental studies Open
View article: ENaC gene variants and their involvement in Covid‑19 severity
ENaC gene variants and their involvement in Covid‑19 severity Open
Epidemiological studies report the association of diverse cardiovascular conditions with coronavirus disease 2019 (COVID-19), but the causality has remained to be established. Specific genetic factors and the extent to which they can expla…
View article: The Interaction of Complement and Intrinsic Coagulation System: A Comparative Study between COVID-19 and Bacterial Sepsis Patients
The Interaction of Complement and Intrinsic Coagulation System: A Comparative Study between COVID-19 and Bacterial Sepsis Patients Open
Background/Objectives: Through the past several years, a constant interaction has been implicated between complement and coagulation cascades. SARS-CoV-2 infection and bacterial sepsis are potent activators of both cascades. This study aim…
View article: Clinical Phenotyping for Prognosis and Immunotherapy Guidance in Bacterial Sepsis and COVID-19
Clinical Phenotyping for Prognosis and Immunotherapy Guidance in Bacterial Sepsis and COVID-19 Open
OBJECTIVES: It is suggested that sepsis may be classified into four clinical phenotypes, using an algorithm employing 29 admission parameters. We applied a simplified phenotyping algorithm among patients with bacterial sepsis and severe CO…
View article: Similarities and differences of Acute RespiratoryDistress Syndrome (ARDS) caused by H1N1 versusSARS-CoV-2 in pregnancy: A systematic review ofcohort studies
Similarities and differences of Acute RespiratoryDistress Syndrome (ARDS) caused by H1N1 versusSARS-CoV-2 in pregnancy: A systematic review ofcohort studies Open
1. Pandemic (H1N1) 2009 - update 105. World Health Organization. June 18, 2010. Accessed October 21, 2022. https://www.who.int/emergencie... Google Scholar
View article: The utility of lung ultrasound in COVID-19 pneumoniain the intensive care unit in real life settings
The utility of lung ultrasound in COVID-19 pneumoniain the intensive care unit in real life settings Open
1. Laursen CB, Clive A, Hallifax R, et al. European Respiratory Society statement on thoracic ultrasound. Eur Respir J. 2021;57(3):2001519. doi:10.1183/13993003.01519-2020. CrossRef Google Scholar
View article: Effect of prone position in non-intubated COVID-19patients
Effect of prone position in non-intubated COVID-19patients Open
1. Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed. 2020;91(1):157-160. doi:10.23750/abm.v91i1.9397 CrossRef Google Scholar
View article: Understanding the nebulisation of antibiotics: the key role of lung microdialysis studies
Understanding the nebulisation of antibiotics: the key role of lung microdialysis studies Open
View article: Strong ion gap and anion gap corrected for albumin and lactate in patients with sepsis in the intensive care unit
Strong ion gap and anion gap corrected for albumin and lactate in patients with sepsis in the intensive care unit Open
[AGcl] and [SIG] demonstrate excellent correlation in septic patients, with a mean difference of about 12 mEq/l. Both parameters failed to demonstrate any predictive ability regarding patient mortality.
View article: Effect of a Sort Term Integrated Care Program on Exercise Tolerance, Quality of Life and Functional Capacity in Patients with Long Covid-19 Syndrome
Effect of a Sort Term Integrated Care Program on Exercise Tolerance, Quality of Life and Functional Capacity in Patients with Long Covid-19 Syndrome Open
Background: Exercise tolerance, quality of life (QoL) and functional capacity are reduced in patients suffering from long COVID-19 syndrome several months after the acute phase of the disease. The effect of an ordinary pulmonary rehabilita…
View article: Low T3 Syndrome in severely ill patients with COVID-19 infection
Low T3 Syndrome in severely ill patients with COVID-19 infection Open
1. Dimopoulos G, Sakelliou A, Flevari A, Tzannis K, Giamarellos - Bourboulis J. Ferritin levels in critically ill patients with COVID-19: A marker of outcome? Pneumon. 2021;34(2):5. doi:10.18332/pne/135958 CrossRef Google Scholar
View article: Critically ill COVID-19 patients with obstructivepulmonary diseases: Characteristics, risk factors andoutcome
Critically ill COVID-19 patients with obstructivepulmonary diseases: Characteristics, risk factors andoutcome Open
1. Bousquet J, Mantzouranis E, Cruz AA, et al. Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol. 2010;126(5):926-9…
View article: The Real Impact of Age on Mortality in Critically Ill COVID-19 Patients
The Real Impact of Age on Mortality in Critically Ill COVID-19 Patients Open
Objective: The impact of severe infection from COVID-19 and the resulting need for life support in an ICU environment is a fact that caused immense pressure in healthcare systems around the globe. Accordingly, elderly people faced multiple…
View article: COVID-19 Outcomes and Diabetes Mellitus: A Comprehensive Multicenter Prospective Cohort Study
COVID-19 Outcomes and Diabetes Mellitus: A Comprehensive Multicenter Prospective Cohort Study Open
The link between type 2 diabetes (T2D) and the severe outcomes of COVID-19 has raised concerns about the optimal management of patients with T2D. This study aimed to investigate the clinical characteristics and outcomes of T2D patients hos…
View article: Modified SCOPE (mSCOPE) Score as a Tool to Predict Mortality in COVID-19 Critically Ill Patients
Modified SCOPE (mSCOPE) Score as a Tool to Predict Mortality in COVID-19 Critically Ill Patients Open
Introduction: Efficient clinical scores predicting the outcome of severe COVID-19 pneumonia may play a pivotal role in patients’ management. The aim of this study was to assess the modified Severe COvid Prediction Estimate score (mSCOPE) i…
View article: Tracheal resection in patients post–COVID-19 is associated with high reintervention rate and early restenosis
Tracheal resection in patients post–COVID-19 is associated with high reintervention rate and early restenosis Open
Objectives: A remarkable increase in the number of patients presenting with tracheal complications after prolonged endotracheal intubation and mechanical ventilation for the management of the severe COVID-19–associated respiratory failure …
View article: Rehabilitation-Induced Benefits Do Not Differ between Men and Women with Long Covid-19 Syndrome
Rehabilitation-Induced Benefits Do Not Differ between Men and Women with Long Covid-19 Syndrome Open
View article: Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial
Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial Open
Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in preventing PA nosocomia…
View article: Pharmacokinetic Characteristics of Nebulized Colistimethate Sodium Using Two Different Types of Nebulizers in Critically Ill Patients with Ventilator-Associated Respiratory Infections
Pharmacokinetic Characteristics of Nebulized Colistimethate Sodium Using Two Different Types of Nebulizers in Critically Ill Patients with Ventilator-Associated Respiratory Infections Open
Background: Rising antimicrobial resistance has led to a revived interest in inhaled colistin treatment in the critically ill patient with ventilator-associated respiratory infection (VARI). Nebulization via vibrating mesh nebulizers (VMNs…
View article: Toward personalized immunotherapy in sepsis: The PROVIDE randomized clinical trial
Toward personalized immunotherapy in sepsis: The PROVIDE randomized clinical trial Open
View article: Daily Physical Activity in Asthma and the Effect of Mepolizumab Therapy
Daily Physical Activity in Asthma and the Effect of Mepolizumab Therapy Open
For the various asthma-specific beneficial effects of physical activity, daily physical activity (DPA) and the potential of asthma therapies on DPA require better characterization. Hence, we aimed to determine (a) the DPA of asthma patient…
View article: Fungal Infections in the ICU during the COVID-19 Era: Descriptive and Comparative Analysis of 178 Patients
Fungal Infections in the ICU during the COVID-19 Era: Descriptive and Comparative Analysis of 178 Patients Open
Background: COVID-19-associated fungal infections seem to be a concerning issue. The aim of this study was to assess the incidence of fungal infections, the possible risk factors, and their effect on outcomes of critically ill patients wit…
View article: A Novel Non-invasive Index of Cardiopulmonary Reserve for the Prediction of Failure of Weaning From Mechanical Ventilation
A Novel Non-invasive Index of Cardiopulmonary Reserve for the Prediction of Failure of Weaning From Mechanical Ventilation Open
View article: Fungal Infections in Critically Ill COVID-19 Patients: Inevitabile Malum
Fungal Infections in Critically Ill COVID-19 Patients: Inevitabile Malum Open
Patients with severe COVID-19 belong to a population at high risk of invasive fungal infections (IFIs), with a reported incidence of IFIs in critically ill COVID-19 patients ranging between 5% and 26.7%. Common factors in these patients, s…
View article: COVID-19 Patients Presenting with Post-Intubation Upper Airway Complications: A Parallel Epidemic?
COVID-19 Patients Presenting with Post-Intubation Upper Airway Complications: A Parallel Epidemic? Open
During the current pandemic, we witnessed a rise of post-intubation tracheal stenosis (PITS) in patients intubated due to COVID-19. We prospectively analyzed data from patients referred to our institution during the last 18 months for seve…
View article: Towards Personalized Immunotherapy in Sepsis: The PROVIDE Randomized Clinical Trial
Towards Personalized Immunotherapy in Sepsis: The PROVIDE Randomized Clinical Trial Open
View article: Thromboinflammation in Sepsis and Heparin: A Review of Literature and Pathophysiology
Thromboinflammation in Sepsis and Heparin: A Review of Literature and Pathophysiology Open
Clinical trials among sepsis patients have indicated that the thromboinflammatory process is more complex than believed, as adverse bleeding events continue to occur despite the use of anticoagulants with different pharmacodynamics. Howeve…
View article: Immunostimulation and Coagulopathy in COVID-19 Compared to Patients With H1N1 Pneumonia or Bacterial Sepsis
Immunostimulation and Coagulopathy in COVID-19 Compared to Patients With H1N1 Pneumonia or Bacterial Sepsis Open
Increased immunostimulation was noted in COVID-19 patients compared to other septic patients; however, this was not accompanied by greater disturbance of the clotting system and/or more severe endothelial injury.
View article: Weaning Failure in Critically Ill Patients Is Related to the Persistence of Sepsis Inflammation
Weaning Failure in Critically Ill Patients Is Related to the Persistence of Sepsis Inflammation Open
Introduction: Septic patients undergoing mechanical ventilation (MV) often experience difficulty in weaning. Th aim of this study was to determine whether inflammatory biomarkers of sepsis could be indicative of the failure or success of s…