Antonin Tutter
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View article: Identification and characterization of ternary complexes consisting of FKBP12, MAPRE1 and macrocyclic molecular glues
Identification and characterization of ternary complexes consisting of FKBP12, MAPRE1 and macrocyclic molecular glues Open
Protein array screening revealed a macrocyclic glue that recruits MAPRE1 to FKBP12. The corresponding ternary complex was characterized and the compound-dependent inhibition of a native MAPRE1 interaction was demonstrated in a cellular ass…
View article: A small molecule VHL molecular glue degrader for cysteine dioxygenase 1
A small molecule VHL molecular glue degrader for cysteine dioxygenase 1 Open
The Von Hippel-Lindau Tumor Suppressor gene product (pVHL) is an E3 ligase substrate receptor that binds proline-hydroxylated HIF1-α, leading to its ubiquitin-dependent degradation. By using protein arrays, we identified a small molecule t…
View article: Rational Screening for Cooperativity in Small-Molecule Inducers of Protein–Protein Associations
Rational Screening for Cooperativity in Small-Molecule Inducers of Protein–Protein Associations Open
The hallmark of a molecular glue is its ability to induce cooperative protein-protein interactions, leading to the formation of a ternary complex, despite weaker binding toward one or both individual proteins. Notably, the extent of cooper…
View article: Rational screening for cooperativity in small-molecule inducers of protein–protein associations
Rational screening for cooperativity in small-molecule inducers of protein–protein associations Open
The hallmark of a molecular glue is its ability to induce cooperative protein–protein interactions, leading to the formation of a ternary complex, despite weaker binding towards one or both individual proteins. Notably, the extent of coope…
View article: DNA-encoded library (DEL)-enabled discovery of proximity-inducing small molecules
DNA-encoded library (DEL)-enabled discovery of proximity-inducing small molecules Open
Molecular glues and bifunctional compounds that induce protein–protein associations provide a powerful and general mechanism to modulate cell circuitry. We sought to develop a platform for the direct discovery of compounds able to induce a…