Antonina Shvetsova
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View article: A hunt for <i>OM45</i> synthetic petite interactions in <i>Saccharomyces cerevisiae</i> reveals a role for Miro GTPase Gem1p in cristae structure maintenance
A hunt for <i>OM45</i> synthetic petite interactions in <i>Saccharomyces cerevisiae</i> reveals a role for Miro GTPase Gem1p in cristae structure maintenance Open
Om45 is a major protein of the yeast's outer mitochondrial membrane under respiratory conditions. However, the cellular role of the protein has remained obscure. Previously, deletion mutant phenotypes have not been found, and clear amino a…
View article: Non-electron transfer chain mitochondrial defects differently regulate HIF-1α degradation and transcription
Non-electron transfer chain mitochondrial defects differently regulate HIF-1α degradation and transcription Open
Mitochondria are the main consumers of molecular O2 in a cell as well as an abundant source of reactive oxygen species (ROS). Both, molecular oxygen and ROS are powerful regulators of the hypoxia-inducible factor-1α-subunit (HIF…
View article: The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system
The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system Open
Cardiovascular diseases are among the leading causes of death worldwide. Reactive oxygen species (ROS) can act as damaging molecules but also represent central hubs in cellular signalling networks. Increasing evidence indicates that ROS pl…
View article: Quantitative Changes in <i>Gimap3</i> and <i>Gimap5</i> Expression Modify Mitochondrial DNA Segregation in Mice
Quantitative Changes in <i>Gimap3</i> and <i>Gimap5</i> Expression Modify Mitochondrial DNA Segregation in Mice Open
Mammalian mitochondrial DNA (mtDNA) is a high-copy maternally inherited genome essential for aerobic energy metabolism. Mutations in mtDNA can lead to heteroplasmy, the co-occurence of two different mtDNA variants in the same cell, which c…