Antonino Cucinotta
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View article: MEX3A is a diagnostic, independent prognostic biomarker and a promising therapeutic target in glioblastoma
MEX3A is a diagnostic, independent prognostic biomarker and a promising therapeutic target in glioblastoma Open
Objective Gliomas are the most common malignant brain tumors with a poor prognosis. Despite advances in molecular profiling, no targeted therapies significantly improve survival. Recently, it has been demonstrated that high expression of M…
View article: MDB-29. SALL4 IS A CRL3REN/KCTD11 SUBSTRATE THAT DRIVES SONIC HEDGEHOG-DEPENDENT MEDULLOBLASTOMA
MDB-29. SALL4 IS A CRL3REN/KCTD11 SUBSTRATE THAT DRIVES SONIC HEDGEHOG-DEPENDENT MEDULLOBLASTOMA Open
BACKGROUND Medulloblastoma (MB) is the most common malignant pediatric brain tumor arising from alterations in cerebellum development. The Sonic Hedgehog variant (SHH MB) is the best genetically characterized, however the molecular mechani…
View article: MEX3A is a new diagnostic, independent prognostic biomarker and a promising therapeutic target in gliomas
MEX3A is a new diagnostic, independent prognostic biomarker and a promising therapeutic target in gliomas Open
Gliomas are the most common malignant brain tumors with a dismal prognosis. Despite the progress in defining molecular features, no therapies targeting the known biomarkers significantly increase the survival rate of glioma patients. Recen…
View article: Hedgehog Pathway Inhibition by Novel Small Molecules Impairs Melanoma Cell Migration and Invasion under Hypoxia
Hedgehog Pathway Inhibition by Novel Small Molecules Impairs Melanoma Cell Migration and Invasion under Hypoxia Open
Melanoma is the principal cause of death in skin cancer due to its ability to invade and cause metastasis. Hypoxia, which characterises the tumour microenvironment (TME), plays an important role in melanoma development, as cancer cells can…
View article: SALL4 is a CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma
SALL4 is a CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma Open