Antonio Angeloni
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View article: Tobacco Smoke Exposure and Oxidative Stress: The Role of Circulating Lipopolysaccharides in Heated and Conventional Products
Tobacco Smoke Exposure and Oxidative Stress: The Role of Circulating Lipopolysaccharides in Heated and Conventional Products Open
Background: Exposure to tobacco smoke, from conventional tobacco cigarettes (CTC) or heated tobacco products (HTPs), increases oxidative stress, causing endothelial dysfunction and higher cardiovascular risk. It is unclear whether smoke ex…
View article: Effect of sitagliptin vs. placebo on bone mineralization in women with type 2 diabetes: the SLowDOWN (SitagLiptin in Diabetes for Osteoporosis in WomeN) randomized clinical trial
Effect of sitagliptin vs. placebo on bone mineralization in women with type 2 diabetes: the SLowDOWN (SitagLiptin in Diabetes for Osteoporosis in WomeN) randomized clinical trial Open
View article: Establishing a Decision-Making Threshold for PIVKA II in the Diagnosis of Pancreatic Ductal Adenocarcinoma (PDAC): A Single Centre Experience
Establishing a Decision-Making Threshold for PIVKA II in the Diagnosis of Pancreatic Ductal Adenocarcinoma (PDAC): A Single Centre Experience Open
This study establishes a novel cut-off for PIVKA II in PDAC, supporting its utility as a biomarker. Further research is needed to validate these findings across diverse populations.
View article: Milder Form of Cobalamin C Disease May Be Missed by Newborn Screening: The Importance of Methylmalonic Acid Assessment
Milder Form of Cobalamin C Disease May Be Missed by Newborn Screening: The Importance of Methylmalonic Acid Assessment Open
CblC deficiency is the most common intracellular disorder of vitamin B12 metabolism. Expanded newborn screening (NBS) plays a key role in early diagnosis, allowing timely treatment and preventing serious complications. However, traditional…
View article: Telemedicine-based adapted physical activity programs for pediatric oncology patients in active oncological care: a feasibility study
Telemedicine-based adapted physical activity programs for pediatric oncology patients in active oncological care: a feasibility study Open
Background Survival rates for pediatric hematological malignancies have significantly improved over the last 50 years. However, children undergoing cancer treatment face long- term health challenges, including musculoskeletal impairments a…
View article: Validated methods for isolation and qualification of mesenchymal stromal/stem cells from different sources
Validated methods for isolation and qualification of mesenchymal stromal/stem cells from different sources Open
View article: Association of Circulating GDF-15 with Fetal Growth in Gestational Diabetes
Association of Circulating GDF-15 with Fetal Growth in Gestational Diabetes Open
Background/Objectives: Growth differentiation factor-15 (GDF-15) is a component of the transforming growth factor beta (TGF-β) family that may act as regulator of inflammation. A possible protective role of GDF-15 against glucose alteratio…
View article: Deciphering the Transcriptional Metabolic Profile of Adipose-Derived Stem Cells During Osteogenic Differentiation and Epigenetic Drug Treatment
Deciphering the Transcriptional Metabolic Profile of Adipose-Derived Stem Cells During Osteogenic Differentiation and Epigenetic Drug Treatment Open
Adipose-derived mesenchymal stem cells (ASCs) are commonly employed in clinical treatment for various diseases due to their ability to differentiate into multi-lineage and anti-inflammatory/immunomodulatory properties. Preclinical studies …
View article: Impact of a very low‐calorie ketogenic diet on metabolic and microbiota outcomes in post‐bariatric patients and bariatric‐Naïve individuals: A comparative pilot study
Impact of a very low‐calorie ketogenic diet on metabolic and microbiota outcomes in post‐bariatric patients and bariatric‐Naïve individuals: A comparative pilot study Open
Aims To date, bariatric surgery (BS) is the most effective long‐term treatment for obesity, but weight regain (WR) is common. The very low‐calorie ketogenic diet (VLCKD) is effective for weight loss and may influence gut microbiota (GM) co…
View article: DNA Sequence Variations Affecting Serotonin Transporter Transcriptional Regulation and Activity: Do They Impact Alcohol Addiction?
DNA Sequence Variations Affecting Serotonin Transporter Transcriptional Regulation and Activity: Do They Impact Alcohol Addiction? Open
Genetic features of alcohol dependence have been extensively investigated in recent years. A large body of studies has underlined the important role of genetic variants not only in metabolic pathways but also in the neurobiology of alcohol…
View article: Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency
Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency Open
Background: We assessed the long-term (24 months) efficacy and safety of monthly calcifediol (0.266 mg) in the correction and maintenance of total 25(OH)D levels in postmenopausal women with basal values <30 ng/mL. Methods: We initially en…
View article: Keeping university open did not increase the risk of SARS-CoV-2 acquisition: A test negative case-control study among students
Keeping university open did not increase the risk of SARS-CoV-2 acquisition: A test negative case-control study among students Open
Background During the SARS-CoV-2 testing program offered through the RT-PCR test by Sapienza University of Rome, we conducted a test-negative case-control study to identify risk factors for acquiring SARS-CoV-2 infection among university s…
View article: PANC-1 Cell Line as an Experimental Model for Characterizing PIVKA-II Production, Distribution, and Molecular Mechanisms Leading to Protein Release in PDAC
PANC-1 Cell Line as an Experimental Model for Characterizing PIVKA-II Production, Distribution, and Molecular Mechanisms Leading to Protein Release in PDAC Open
Pancreatic ductal adenocarcinoma (PDAC) represents a highly aggressive malignancy with a lack of reliable diagnostic biomarkers. Protein induced by vitamin K absence (PIVKA-II) is a protein increased in various cancers (particularly in hep…
View article: Impact of SARS-CoV-2 vaccination on FcγRIIIA/CD16 dynamics in Natural Killer cells: relevance for antibody-dependent functions
Impact of SARS-CoV-2 vaccination on FcγRIIIA/CD16 dynamics in Natural Killer cells: relevance for antibody-dependent functions Open
Introduction Natural Killer (NK) cells contribute to the protective effects of vaccine-induced antibodies thanks to the low affinity receptor for IgG, FcγRIIIA/CD16, whose aggregation leads to the killing of infected cells and IFNγ release…
View article: Stereoselective Voltammetric Biosensor for Myo-Inositol and D-Chiro-Inositol Recognition
Stereoselective Voltammetric Biosensor for Myo-Inositol and D-Chiro-Inositol Recognition Open
This paper describes the development of a simple voltammetric biosensor for the stereoselective discrimination of myo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) by means of bovine serum albumin (BSA) adsorption onto a multi-wall…
View article: Epstein-Barr virus–encoded EBNA2 downregulates ICOSL by inducing miR-24 in B-cell lymphoma
Epstein-Barr virus–encoded EBNA2 downregulates ICOSL by inducing miR-24 in B-cell lymphoma Open
Hematological malignancies such as Burkitt lymphoma (BL), Hodgkin lymphoma (HL), and diffuse large B-cell lymphoma (DLBCL) cause significant morbidity in humans. A substantial number of these lymphomas, particularly HL and DLBCLs have poor…
View article: Early Energy Intake and Amino Acid Profile in Preterm Newborns: A Quasi-Experimental Study
Early Energy Intake and Amino Acid Profile in Preterm Newborns: A Quasi-Experimental Study Open
(1) Background: An increased protein intake via parenteral nutrition (PN) in early life is associated with an improvement of the nitrogen balance in preterm newborns. However, the role of energy intake on amino acid (AA) utilization provid…
View article: Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis
Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis Open
Currently, ovarian cancer (OC) is a target of intense biomarkers research because of its frequent late diagnosis and poor prognosis. Serum determination of Human epididymis protein 4 (HE4) is a very important early detection test. Most int…
View article: Anti-N SARS-CoV-2 assays for evaluation of natural viral infection
Anti-N SARS-CoV-2 assays for evaluation of natural viral infection Open
Comparison between of three analytical systems available for anti-N SARS-CoV-2 IgG and IgM antibodies showed a general agreement when compared to detect total and G class immunoglobulins, while doubtful or discordant results have been high…
View article: Recent Insight About HE4 Role in Ovarian Cancer Oncogenesis
Recent Insight About HE4 Role in Ovarian Cancer Oncogenesis Open
Currently, ovarian cancer (OC) is a target of intense biomarkers research because of its frequent late diagnosis and poor prognosis. Serum determination of Human epididymis protein 4 (HE4) is a very important early detection test. Most int…
View article: Myo-Inositol and D-Chiro-Inositol as Modulators of Ovary Steroidogenesis: A Narrative Review
Myo-Inositol and D-Chiro-Inositol as Modulators of Ovary Steroidogenesis: A Narrative Review Open
Myo-inositol is a natural polyol, the most abundant among the nine possible structural isomers available in living organisms. Inositol confers some distinctive traits that allow for a striking distinction between prokaryotes and eukaryotes…
View article: Urine Dipstick Analysis on Automated Platforms: Is a Reliable Screening Tool for Proteinuria? An Experience from Umberto I Hospital in Rome
Urine Dipstick Analysis on Automated Platforms: Is a Reliable Screening Tool for Proteinuria? An Experience from Umberto I Hospital in Rome Open
Urinalysis is commonly used as a screening tool for kidney disease. In many cases, the dipstick urine assay includes the assessment of albumin/protein and creatinine; consequently, the value of their ratio is available on the urine section…
View article: Efficacy of N-Acetylcysteine on Endometriosis-Related Pain, Size Reduction of Ovarian Endometriomas, and Fertility Outcomes
Efficacy of N-Acetylcysteine on Endometriosis-Related Pain, Size Reduction of Ovarian Endometriomas, and Fertility Outcomes Open
Background: Endometriosis is a chronic, estrogen-dependent, inflammatory disease, whose pivotal symptoms are dysmenorrhea, dyspareunia, and chronic pelvic pain (CPP). Besides the usual medical treatments, recent evidence suggests there are…
View article: Obesity-Associated Hepatic Steatosis, Somatotropic Axis Impairment, and Ferritin Levels Are Strong Predictors of COVID-19 Severity
Obesity-Associated Hepatic Steatosis, Somatotropic Axis Impairment, and Ferritin Levels Are Strong Predictors of COVID-19 Severity Open
The full spectrum of SARS-CoV-2-infected patients has not yet been defined. This study aimed to evaluate which parameters derived from CT, inflammatory, and hormonal markers could explain the clinical variability of COVID-19. We performed …
View article: SARS-CoV-2 Infection in Pregnancy: Clues and Proof of Adverse Outcomes
SARS-CoV-2 Infection in Pregnancy: Clues and Proof of Adverse Outcomes Open
Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) represents one of the most threatening viral infections in the last decade. Amongst susceptible individuals, infected pregnant women might be predisposed to severe co…
View article: Phenotypes and Genotypes of Inherited Disorders of Biogenic Amine Neurotransmitter Metabolism
Phenotypes and Genotypes of Inherited Disorders of Biogenic Amine Neurotransmitter Metabolism Open
Inherited disorders of biogenic amine metabolism are genetically determined conditions resulting in dysfunctions or lack of enzymes involved in the synthesis, degradation, or transport of dopamine, serotonin, adrenaline/noradrenaline, and …
View article: Disposable Voltammetric Immunosensor for D-Dimer Detection as Early Biomarker of Thromboembolic Disease and of COVID-19 Prognosis
Disposable Voltammetric Immunosensor for D-Dimer Detection as Early Biomarker of Thromboembolic Disease and of COVID-19 Prognosis Open
In this work, we report on the development of a simple electrochemical immunosensor for the detection of D-dimer protein in human plasma samples. The immunosensor is built by a simple drop-casting procedure of chitosan nanoparticles (CSNPs…
View article: Interleukin 18 and IL-18 BP response to Sars-CoV-2 virus infection
Interleukin 18 and IL-18 BP response to Sars-CoV-2 virus infection Open
The immune response to the SARS-CoV-2 infection is crucial to the patient outcome. IL-18 is involved in the lymphocyte response to the disease and it is well established its important role in the complex developing of the host response to …
View article: European survey of newborn bloodspot screening for CF: opportunity to address challenges and improve performance
European survey of newborn bloodspot screening for CF: opportunity to address challenges and improve performance Open
View article: Space Biomedicine: A Unique Opportunity to Rethink the Relationships between Physics and Biology
Space Biomedicine: A Unique Opportunity to Rethink the Relationships between Physics and Biology Open
Space biomedicine has provided significant technological breakthroughs by developing new medical devices, diagnostic tools, and health-supporting systems. Many of these products are currently in use onboard the International Space Station …