Antonio Cittadini
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View article: Circulating miR-10b-5p, miR-193a-3p, and miR-1-3p Are Deregulated in Patients with Heart Failure and Correlate with Hormonal Deficiencies
Circulating miR-10b-5p, miR-193a-3p, and miR-1-3p Are Deregulated in Patients with Heart Failure and Correlate with Hormonal Deficiencies Open
Heart failure (HF) is among the most important causes of worldwide morbidity, hospitalisation, and mortality. A reduction in anabolic hormonal axes seems to potentially play an important role in chronic HF progression and prognosis. Severa…
View article: Cardio-Oncology Challenges in Elderly Patients
Cardio-Oncology Challenges in Elderly Patients Open
Background and Objectives: Along with the ageing of the population, cancer and cardiovascular (CV) diseases more frequently coexist, complicating patients’ management. Here, we focus on elderly oncologic patients, describing clinical featu…
View article: Statin therapy in chronic heart failure with reduced ejection fraction: a post-hoc analysis of T.O.S.C.A. Registry
Statin therapy in chronic heart failure with reduced ejection fraction: a post-hoc analysis of T.O.S.C.A. Registry Open
Background Statin treatment (ST) reduce the incidence of Myocardial Infarction (MI) and death for Coronary Artery Disease (CAD)1 and the first occurrence of Heart Failure (HF) in individuals with CAD2. However, the beneficial effect of ST …
View article: A pulmonary hypertension targeted algorithm to improve referral to right heart catheterization: a machine learning approach
A pulmonary hypertension targeted algorithm to improve referral to right heart catheterization: a machine learning approach Open
Background Pulmonary hypertension (PH) is a pathophysiological problem that may involve several clinical symptoms and be linked to various respiratory and cardiovascular illnesses. Its diagnosis is made invasively by Right Cardiac Catheter…
View article: Homozygous familial hypercholesterolemia Evaluation and Survival study in Saudi Arabia (HESSA): genetic and molecular characteristics of the largest genetic cohort in the middle east
Homozygous familial hypercholesterolemia Evaluation and Survival study in Saudi Arabia (HESSA): genetic and molecular characteristics of the largest genetic cohort in the middle east Open
Homozygous Familial Hypercholesterolemia (HoFH) is a rare, genetic disorder caused by bi-allelic mutations in key genes responsible for lipid metabolism. This results in significantly elevated LDL-C levels, leading to early onset cardiovas…
View article: Post-implantation syndrome in patients undergoing thoracic and abdominal endovascular aortic repair: Comprehensive systematic review and meta-analysis
Post-implantation syndrome in patients undergoing thoracic and abdominal endovascular aortic repair: Comprehensive systematic review and meta-analysis Open
Post-implantation syndrome (PIS) can lead to prolonged hospitalization and major adverse cardiovascular events (MACE). This systematic review and meta-analysis investigated the clinical profile of PIS after abdominal (EVAR) and thoracic en…
View article: The Role of Aging in Heart Failure With Preserved Ejection Fraction
The Role of Aging in Heart Failure With Preserved Ejection Fraction Open
View article: Growth Hormone Replacement Therapy in Heart Failure With Reduced Ejection Fraction
Growth Hormone Replacement Therapy in Heart Failure With Reduced Ejection Fraction Open
This randomized, double-blind, placebo-controlled trial demonstrates that GH replacement therapy in HFrEF patients with GHD improves exercise performance, and left ventricular and right ventricular structure and function, leading to an ame…
View article: Sex-Specific Differences in Echocardiographic Parameters of Risk Stratification in Pulmonary Arterial Hypertension
Sex-Specific Differences in Echocardiographic Parameters of Risk Stratification in Pulmonary Arterial Hypertension Open
This is the first study focusing on sex differences in right heart size obtained by echocardiography in patients with PAH. For risk stratification indexing RA area to body surface area could be more reflective of body composition. In contr…
View article: The chronic heart failure evolutions: Different fates and routes
The chronic heart failure evolutions: Different fates and routes Open
Aims Individual prognostic assessment and disease evolution pathways are undefined in chronic heart failure (HF). The application of unsupervised learning methodologies could help to identify patient phenotypes and the progression in each …
View article: Beneficial Effects on Exercise Capacity Associated with a Combination of Lactoferrin, Lysozyme, Lactobacillus, Resveratrol, Vitamins, and Oligoelements in Patients with Post-COVID-19 Syndrome: A Single-Center Retrospective Study
Beneficial Effects on Exercise Capacity Associated with a Combination of Lactoferrin, Lysozyme, Lactobacillus, Resveratrol, Vitamins, and Oligoelements in Patients with Post-COVID-19 Syndrome: A Single-Center Retrospective Study Open
Background/Objectives: Although long-term COVID-19 symptoms are common, little is known about the management of post-COVID-19 condition. The aim of the current report is to evaluate the effects of a combination of lactoferrin, lysozyme, la…
View article: A matter of sex—persistent predictive value of MECKI score prognostic power in men and women with heart failure and reduced ejection fraction: a multicenter study
A matter of sex—persistent predictive value of MECKI score prognostic power in men and women with heart failure and reduced ejection fraction: a multicenter study Open
Background A sex-based evaluation of prognosis in heart failure (HF) is lacking. Methods and results We analyzed the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score registry, which includes HF with reduc…
View article: Impact of electronic cigarettes (e-cigs) and heat-not-burn/heated tobacco products (HnB/HTP) on asthma and chronic obstructive pulmonary disease: a viewpoint of the Italian Society of Internal Medicine
Impact of electronic cigarettes (e-cigs) and heat-not-burn/heated tobacco products (HnB/HTP) on asthma and chronic obstructive pulmonary disease: a viewpoint of the Italian Society of Internal Medicine Open
View article: Exercise Pulmonary Hypertension in Heart Valve Disease
Exercise Pulmonary Hypertension in Heart Valve Disease Open
The optimal management of heart valve disease (HVD) is still debated and many studies are underway to identify the best time to refer patients for the most appropriate treatment strategy (either conservative, surgical or transcatheter inte…
View article: Acute heart failure – an EFIM guideline critical appraisal and adaptation for internists
Acute heart failure – an EFIM guideline critical appraisal and adaptation for internists Open
View article: Cardiac rehabilitation and acute aortic dissection: understanding and addressing the evidence GAP a systematic review
Cardiac rehabilitation and acute aortic dissection: understanding and addressing the evidence GAP a systematic review Open
Despite guideline recommendations, strategies for implementing cardiac rehabilitation (CR) in patients with acute aortic dissection (AAD) are not well established with little evidence to risk stratify prudent and effective guidelines for t…
View article: Vein wall thickness and severity of pulmonary involvement due to sars n-cov2 virus infection
Vein wall thickness and severity of pulmonary involvement due to sars n-cov2 virus infection Open
View article: Modulating NO–GC Pathway in Pulmonary Arterial Hypertension
Modulating NO–GC Pathway in Pulmonary Arterial Hypertension Open
The pathogenesis of complex diseases such as pulmonary arterial hypertension (PAH) is entirely rooted in changes in the expression of some vasoactive factors. These play a significant role in the onset and progression of the disease. Indee…
View article: Corrigendum to “How cardiologists can manage excess body weight and related cardiovascular risk. An expert opinion” [International Journal of Cardiology 2023 381C 101–104]
Corrigendum to “How cardiologists can manage excess body weight and related cardiovascular risk. An expert opinion” [International Journal of Cardiology 2023 381C 101–104] Open
View article: Heart failure patients with improved ejection fraction: Insights from the <scp>MECKI</scp> score database
Heart failure patients with improved ejection fraction: Insights from the <span>MECKI</span> score database Open
Aims Improvement of left ventricular ejection fraction is a major goal of heart failure (HF) treatment. However, data on clinical characteristics, exercise performance and prognosis in HF patients who improved ejection fraction (HFimpEF) a…
View article: Rationale and protocol of a double-blind, randomized, placebo-controlled trial to test the efficacy, safety, and tolerability of dimethyl fumarate in Friedreich Ataxia (DMF-FA-201)
Rationale and protocol of a double-blind, randomized, placebo-controlled trial to test the efficacy, safety, and tolerability of dimethyl fumarate in Friedreich Ataxia (DMF-FA-201) Open
Introduction Friedreich Ataxia (FRDA) is an autosomal recessive neurodegenerative disorder that causes gait and limb ataxia, dysarthria, and impaired vibratory sense, with cardiomyopathy being the predominant cause of death. There is no ap…
View article: Identification of Drugs Acting as Perpetrators in Common Drug Interactions in a Cohort of Geriatric Patients from Southern Italy and Analysis of the Gene Polymorphisms That Affect Their Interacting Potential
Identification of Drugs Acting as Perpetrators in Common Drug Interactions in a Cohort of Geriatric Patients from Southern Italy and Analysis of the Gene Polymorphisms That Affect Their Interacting Potential Open
Background: Pharmacogenomic factors affect the susceptibility to drug–drug interactions (DDI). We identified drug interaction perpetrators among the drugs prescribed to a cohort of 290 older adults and analysed the prevalence of gene polym…
View article: Long-term outcomes following transcatheter aortic valve implantation with the Portico self-expanding valve
Long-term outcomes following transcatheter aortic valve implantation with the Portico self-expanding valve Open
View article: How cardiologists can manage excess body weight and related cardiovascular risk. An expert opinion
How cardiologists can manage excess body weight and related cardiovascular risk. An expert opinion Open
View article: Cardiovascular Side Effects of Anthracyclines and HER2 Inhibitors among Patients with Breast Cancer: A Multidisciplinary Stepwise Approach for Prevention, Early Detection, and Treatment
Cardiovascular Side Effects of Anthracyclines and HER2 Inhibitors among Patients with Breast Cancer: A Multidisciplinary Stepwise Approach for Prevention, Early Detection, and Treatment Open
Cardiovascular (CV) diseases (CVD) are a major cause of long-term morbidity and mortality affecting life expectancy amongst cancer survivors. In recent years, because of the possibility of early diagnosis and the increased efficacy of neo-…
View article: Early Left Ventricular Diastolic Dysfunction in Females with Chronic Hyperprolactinemia: A Doppler Echocardiographic Study
Early Left Ventricular Diastolic Dysfunction in Females with Chronic Hyperprolactinemia: A Doppler Echocardiographic Study Open
Despite the myocardial prolactin (PRL) binding activity and the known effect of enhancing contractility in the isolated rat heart, little information is available concerning the cardiovascular consequences of hyperprolactinemia in humans. …
View article: Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways
Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways Open
Early detection and treatment of cancer have led to a noticeable reduction in both mortality and morbidity. However, chemotherapy and radiotherapy could exert cardiovascular (CV) side effects, impacting survival and quality of life, indepe…
View article: Acute Heart Failure: Diagnostic–Therapeutic Pathways and Preventive Strategies—A Real-World Clinician’s Guide
Acute Heart Failure: Diagnostic–Therapeutic Pathways and Preventive Strategies—A Real-World Clinician’s Guide Open
Acute heart failure (AHF) is the most frequent cause of unplanned hospital admission in patients of >65 years of age and it is associated with significantly increased morbidity, mortality, and healthcare costs. Different AHF classification…
View article: Invasive Fungal Infections in Hospitalized Patients with COVID-19: A Non-Intensive Care Single-Centre Experience during the First Pandemic Waves
Invasive Fungal Infections in Hospitalized Patients with COVID-19: A Non-Intensive Care Single-Centre Experience during the First Pandemic Waves Open
Invasive fungal infections (IFIs) represent a severe complication of COVID-19, yet they are under-estimated. We conducted a retrospective analysis including all the COVID-19 patients admitted to the Infectious Diseases Unit of the Federico…
View article: Short-term effect of sacubitril/valsartan on endothelial dysfunction and arterial stiffness in patients with chronic heart failure
Short-term effect of sacubitril/valsartan on endothelial dysfunction and arterial stiffness in patients with chronic heart failure Open
Heart failure (HF) is associated to endothelial dysfunction that promotes the increase of arterial stiffness thus augmenting myocardial damage. Sacubitril/Valsartan is used in the treatment of HF reduced ejection fraction (HFrEF) and has b…