Antônio Cláudio Lucas da Nóbrega
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View article: Stress during pregnancy alters hepatic renin-angiotensin system and redox homeostasis in a sex- and age-specific manner
Stress during pregnancy alters hepatic renin-angiotensin system and redox homeostasis in a sex- and age-specific manner Open
Prenatal stress may contribute to sex- and age-specific programming of the liver in adult offspring. Our results showed that stress during pregnancy alters the hepatic renin-angiotensin system only at 120-days old and specially in male off…
View article: PDE-5 inhibition mitigates mental stress-induced endothelial dysfunction in resistant hypertension
PDE-5 inhibition mitigates mental stress-induced endothelial dysfunction in resistant hypertension Open
Considering that mental stress (MS)-induced endothelial dysfunction causes major cardiovascular events, the present study explored the involvement of NO-cGMP pathway in resistant hypertension (RH) pathophysiology. Our results suggest that …
View article: Hypoxia disrupts neurovascular regulation of blood pressure in normotensive and untreated hypertensive men
Hypoxia disrupts neurovascular regulation of blood pressure in normotensive and untreated hypertensive men Open
Background Hypoxia is a common feature of arterial hypertension that does not consistently elevate blood pressure (BP), but triggers exaggerated increases in muscle sympathetic nerve activity (MSNA) and may disturb sympathetic transduction…
View article: Hypoxia Disrupts Neurovascular Regulation of Blood Pressure in Normotensive and Untreated Hypertensive Men
Hypoxia Disrupts Neurovascular Regulation of Blood Pressure in Normotensive and Untreated Hypertensive Men Open
Hypoxia is a common feature of arterial hypertension that does not consistently elevate blood pressure (BP), but triggers exaggerated increases in muscle sympathetic nerve activity (MSNA) and may disturb sympathetic transduction and barore…
View article: Electrocardiographic Left Ventricular Mass Trajectories and the Effects of Treatment in Patients at Different Stages of Hypertension
Electrocardiographic Left Ventricular Mass Trajectories and the Effects of Treatment in Patients at Different Stages of Hypertension Open
Background: The comparison of left ventricular mass (LVM) at different BP levels and the effects of antihypertensive drug treatment on LVM are unknown. Objective: To compare the LVM of individuals with prehypertension and Stage 1 hypertens…
View article: Cardiac Baroreflex Is Preserved After the Recovery From COVID‐19 Men and Women
Cardiac Baroreflex Is Preserved After the Recovery From COVID‐19 Men and Women Open
We sought to investigate whether mild COVID‐19 impairs cardiac baroreflex sensitivity (cBRS), using the modified Oxford protocol, in young healthy men and women 12–14 weeks after recovering from the infection. Participants were distributed…
View article: Relationship between resting augmentation index and spontaneous cardiac baroreflex sensitivity during handgrip exercise in postmenopausal women
Relationship between resting augmentation index and spontaneous cardiac baroreflex sensitivity during handgrip exercise in postmenopausal women Open
The stiffening of the conductance arteries is a hallmark of ageing and increases drastically after menopause. Therefore, the augmentation index (AIx), a surrogate for arterial stiffness, could be related to the decline in baroreflex sensit…
View article: Impact of gestational stress on bone and body composition in Wistar rats after lactation
Impact of gestational stress on bone and body composition in Wistar rats after lactation Open
This research aimed to evaluate the impact of stress at the end of the pregnancy on bone health and body composition of Wistar rats after the breastfeeding period. The 90-day pregnant Wistar rats were divided into 2 groups (n=7/group): the…
View article: The burden of physical inactivity for the public health care system in Brazil
The burden of physical inactivity for the public health care system in Brazil Open
OBJECTIVE: To update the estimated cost of physical inactivity for the Brazilian Unified Health System (SUS). METHODS: The hospitalization costs were accessed via a database of the Ministry of Health – Informatics Department of the Brazili…
View article: Reliability of the Coimbra Reactive Agility Soccer Test (CRAST)
Reliability of the Coimbra Reactive Agility Soccer Test (CRAST) Open
Agility is a fitness-skill-related component that should be a part of the standard physiological testing for soccer players and one of the key performance indicators in soccer. The present study aimed to assess the reliability of the CRAST…
View article: The burden of physical inactivity for the public health care system in Brazil
The burden of physical inactivity for the public health care system in Brazil Open
OBJECTIVE To update the estimated cost of physical inactivity for the Brazilian Unified Health System (SUS). METHODS The hospitalization costs were accessed via a database of the Ministry of Health – Informatics Department of the Brazilian…
View article: Mental stress induces endothelial dysfunction by AT1R-mediated redox imbalance in overweight/obese men
Mental stress induces endothelial dysfunction by AT1R-mediated redox imbalance in overweight/obese men Open
The main goal of this study was to determine whether oxidative imbalance mediated by AT1 receptor (AT1R) is responsible for deleterious endothelial responses to mental stress (MS) in overweight/obese class I men. Fifteen overweight/obese m…
View article: AT1R blocker prevents mental stress induced retrograde blood flow in overweight/obese men
AT1R blocker prevents mental stress induced retrograde blood flow in overweight/obese men Open
The main goal was to determine the impact of mental stress (MS) on blood flow regulation in overweight/obese men. Fourteen overweight/obese men (27 ± 7 years; 29.8 ± 2.6 kg/m 2 ) participated in two randomized experimental sessions with or…
View article: Aerobic exercise prevents cardiomyocyte damage caused by oxidative stress in early cardiovascular disease by increasing vascularity while L-arginine supplementation prevents it by increasing activation of the enzyme nitric oxide synthase
Aerobic exercise prevents cardiomyocyte damage caused by oxidative stress in early cardiovascular disease by increasing vascularity while L-arginine supplementation prevents it by increasing activation of the enzyme nitric oxide synthase Open
L-Arginine and chronic exercise reduce oxidative stress. However, it is unclear how they affect cardiomyocytes during cardiovascular disease (CVD) development. The aim of this research was to investigate the possible effects of L-arginine …
View article: Respiratory training in older women: Unravelling central and peripheral hemodynamic slow oscillatory patterns
Respiratory training in older women: Unravelling central and peripheral hemodynamic slow oscillatory patterns Open
We hypothesized that inspiratory muscle training (IMT) increases the respiratory-induced low-frequency oscillations of mean blood pressure (MBP) and middle cerebral artery blood velocity (MCAv), upregulating cerebrovascular function in old…
View article: Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men
Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men Open
In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy yo…
View article: Reactive oxygen species play a modulatory role in the hyperventilatory response to poikilocapnic hyperoxia in humans
Reactive oxygen species play a modulatory role in the hyperventilatory response to poikilocapnic hyperoxia in humans Open
Key points The proposed mechanism for the increased ventilation in response to hyperoxia includes a reduced brain CO 2 –[H + ] washout‐induced central chemoreceptor stimulation that results from a decrease in cerebral perfusion and the wea…
View article: Cardiovascular and Autonomic Responses after a Single Bout of Resistance Exercise in Men with Untreated Stage 2 Hypertension
Cardiovascular and Autonomic Responses after a Single Bout of Resistance Exercise in Men with Untreated Stage 2 Hypertension Open
The aim of this paper is to assess the integrated responses of ambulatory blood pressure (BP), cardiac autonomic modulation, spontaneous baroreflex sensitivity (BRS), and vascular reactivity after a single bout of resistance exercise (RE) …
View article: Correction to: Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial
Correction to: Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial Open
A correction to this paper has been published: https://doi.org/10.1007/s00592-021-01689-8.
View article: Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial
Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial Open
Clinical trials registration number: NCT00971165.
View article: K<sub>ATP</sub> channels modulate cerebral blood flow and oxygen delivery during isocapnic hypoxia in humans
K<sub>ATP</sub> channels modulate cerebral blood flow and oxygen delivery during isocapnic hypoxia in humans Open
Key points ATP‐sensitive K + (K ATP ) channels mediate hypoxia‐induced cerebral vasodilatation and hyperperfusion in animals. We tested whether K ATP channels blockade affects the increase in human cerebral blood flow (CBF) and the mainten…
View article: Carotid chemoreflex and muscle metaboreflex interact to the regulation of ventilation in patients with heart failure with reduced ejection fraction
Carotid chemoreflex and muscle metaboreflex interact to the regulation of ventilation in patients with heart failure with reduced ejection fraction Open
Synergism among reflexes probably contributes to exercise hyperventilation in patients with heart failure with reduced ejection fraction (HFrEF). Thus, we investigated whether the carotid chemoreflex and the muscle metaboreflex interact to…
View article: Aerobic exercise modulates cardiac NAD(P)H oxidase and the NRF2/KEAP1 pathway in a mouse model of chronic fructose consumption
Aerobic exercise modulates cardiac NAD(P)H oxidase and the NRF2/KEAP1 pathway in a mouse model of chronic fructose consumption Open
The present study investigated the effects of exercise on the cardiac nuclear factor (erythroid-derived 2) factor 2 (NRF2)/Kelch-like ECH-associated protein 1 (KEAP1) pathway in an experimental model of chronic fructose consumption. Male C…
View article: Differential vasomotor responses to isocapnic hyperoxia: cerebral versus peripheral circulation
Differential vasomotor responses to isocapnic hyperoxia: cerebral versus peripheral circulation Open
Isocapnic hyperoxia (IH) evokes cerebral and peripheral hypoperfusion via both disturbance of redox homeostasis and reduction in nitric oxide (NO) bioavailability. However, it is not clear whether the magnitude of the vasomotor responses d…
View article: Acid-sensing ion channels blockade attenuates pressor and sympathetic responses to skeletal muscle metaboreflex activation in humans
Acid-sensing ion channels blockade attenuates pressor and sympathetic responses to skeletal muscle metaboreflex activation in humans Open
In animals, the blockade of acid-sensing ion channels (ASICs), cation pore-forming membrane proteins located in the free nerve endings of group IV afferent fibers, attenuates increases in arterial pressure (AP) and sympathetic nerve activi…
View article: Transcutaneous electrical nerve stimulation attenuates cardiac sympathetic drive in heart failure: a <sup>123</sup>MIBG myocardial scintigraphy randomized controlled trial
Transcutaneous electrical nerve stimulation attenuates cardiac sympathetic drive in heart failure: a <sup>123</sup>MIBG myocardial scintigraphy randomized controlled trial Open
Cardiac sympathetic overdrive provides inotropic support to the failing heart. However, as myocardial insult evolves, this compensatory response impairs contractile function and constitutes an independent mortality predictor and a primary …
View article: Interpreting the impact of water drinking on arterial baroreflex function: When physiology speaks for itself
Interpreting the impact of water drinking on arterial baroreflex function: When physiology speaks for itself Open
We are happy that our study (Vianna et al., 2018) has received the attention of others and pleased to have the opportunity to respond and debate the merits of our approach. In their Letter to the Editor, Papaioannou et al. (2019) raise som…