António Coutinho
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View article: Intrauterine IPEX
Intrauterine IPEX Open
IPEX is one of the few Inborn Errors of Immunity that may manifest in the fetal period, and its intrauterine forms certainly represent the earliest human autoimmune diseases. Here, we review the clinical, histopathologic, and genetic findi…
View article: TLR9 Signaling Suppresses the Canonical Plasma Cell Differentiation Program in Follicular B Cells
TLR9 Signaling Suppresses the Canonical Plasma Cell Differentiation Program in Follicular B Cells Open
The relative potency and quality of mouse B cell response to Toll-like receptors (TLRs) signaling varies significantly depending on the B cell subset and on the TLR member being engaged. Although it has been shown that marginal zone cells …
View article: Effects of Nintendo Wii® Program in Dual-Task Performance in Older Adults
Effects of Nintendo Wii® Program in Dual-Task Performance in Older Adults Open
A sedentary lifestyle has a strong impact on the older population; so participation in physical activity is important for enhanced physical and mental function, increasing health and well-being. In the elderly, dual- task activities are se…
View article: Early-Onset Autoimmune Disease as a Manifestation of Primary Immunodeficiency
Early-Onset Autoimmune Disease as a Manifestation of Primary Immunodeficiency Open
Autoimmune disorders (AID) have been increasingly observed in association with primary immunodeficiencies (PIDs). Here, we discuss the interface between PID and AID, focusing on autoimmune manifestations early in life, which can be diagnos…