Antônio E. M. Crotti
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View article: Antileishmanial and Antitoxoplasmal Activities of Acetone-Derived Monoketone Curcuminoids
Antileishmanial and Antitoxoplasmal Activities of Acetone-Derived Monoketone Curcuminoids Open
Background/Objectives: Leishmaniasis and toxoplasmosis are zoonoses that cause millions of deaths annually. This study aimed to synthesize and investigate the in vitro antileishmanial and antitoxoplasmal activity of eight ace-tone-derived …
View article: Antileishmanial and Antitoxoplasmal Activities of 1,4-Dihydropyridines
Antileishmanial and Antitoxoplasmal Activities of 1,4-Dihydropyridines Open
We have synthesized 24 1,4-dihydropyridine compounds (1,4-DHPs) with different substituents at the aromatic ring by microwave-assisted one-pot Hantzsch multicomponent reaction and evaluated their in vitro activities against Toxoplasma g…
View article: Antileishmanial and Antitoxoplasmal Activities of 1,4-dihydropyridines
Antileishmanial and Antitoxoplasmal Activities of 1,4-dihydropyridines Open
We have synthesized 24 1,4-dihydropyridine compounds (1,4-DHPs) with different substituents at the aromatic ring by microwave-assisted one-pot Hantzsch multicomponent reac-tion and evaluated their in vitro activities against Toxoplasma gon…
View article: Antimicrobial Activity of N-Methyl 4-Piperidone-Derived Monoketone Curcuminoids Against Cariogenic Bacteria
Antimicrobial Activity of N-Methyl 4-Piperidone-Derived Monoketone Curcuminoids Against Cariogenic Bacteria Open
Background/Objectives: Dental caries and candidiasis are major health problems worldwide. Dental caries is caused by cariogenic bacteria, especially those belonging to the Streptococcus genus, whereas candidiasis is caused by Candida speci…
View article: Antimicrobial activity of N-methyl 4-piperidone derived monoketone curcuminoids agaisnt cariogenic bacteria
Antimicrobial activity of N-methyl 4-piperidone derived monoketone curcuminoids agaisnt cariogenic bacteria Open
Background/Objectives: Dental caries and candidiasis are major health problems worldwide. Dental caries is caused by cariogenic bacteria, especially those belonging to the Streptococcus genus, whereas candidiasis is caused by Candida speci…
View article: Effect of phosphorylated chitosan and carbodiimide on the surface wettability, surface free energy and surface morphology of the eroded dentin
Effect of phosphorylated chitosan and carbodiimide on the surface wettability, surface free energy and surface morphology of the eroded dentin Open
It can be concluded that 2.5% P-Chi and 0.5 mol/L EDC did not impact the surface wettability of the eroded dentin. However, EDC promoted lower surface free energy, while P-Chi altered surface morphology, causing demineralization and the op…
View article: Stereoselective oxidative coupling of methyl trans-ferulate to (±)-trans-dehydrodiferulate dimethyl ester by Trametes versicolor FC: An enantioselective green approach
Stereoselective oxidative coupling of methyl trans-ferulate to (±)-trans-dehydrodiferulate dimethyl ester by Trametes versicolor FC: An enantioselective green approach Open
Chemoenzymatic strategies to synthesize complex molecules have been developed by combining biocatalytic and synthetic methods in a multistep approach toward a target molecule. Dihydrobenzofuran neolignans (DBNs), a class of plant-derived n…
View article: STEREOSELECTIVE OXIDATIVE COUPLING OF METHYL TRANS-FERULATE TO (±)-TRANS-DEHYDRODIFERULATE DIMETHYL ESTER BY Trametes versicolor FC: AN ENANTIOSELECTIVE GREEN APPROACH
STEREOSELECTIVE OXIDATIVE COUPLING OF METHYL TRANS-FERULATE TO (±)-TRANS-DEHYDRODIFERULATE DIMETHYL ESTER BY Trametes versicolor FC: AN ENANTIOSELECTIVE GREEN APPROACH Open
Chemoenzymatic strategies to synthesize complex molecules have been developed by combining biocatalytic and synthetic methods in a multistep approach toward a target molecule. Dihydrobenzofuran neolignans (DBNs), a class of plant-derived n…
View article: RAIMUNDO BRAZ FILHO E SEUS 90 ANOS: MESTRE DA QUÍMICA DE PRODUTOS NATURAIS E INSPIRAÇÃO PARA AS FUTURAS GERAÇÕES
RAIMUNDO BRAZ FILHO E SEUS 90 ANOS: MESTRE DA QUÍMICA DE PRODUTOS NATURAIS E INSPIRAÇÃO PARA AS FUTURAS GERAÇÕES Open
View article: FRAGMENTATION OF DEPROTONATED PLUMERAN INDOLE ALKALOIDS BY ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY
FRAGMENTATION OF DEPROTONATED PLUMERAN INDOLE ALKALOIDS BY ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY Open
The fragmentation of four deprotonated plumeran indole alkaloids (PIAs), namely aspidospermidine (1), demethoxypalosine (2), aspidocarpine (3), and aspidolimine (4), previously isolated from Aspidosperma spruceanum has been investigated by…
View article: Hexane Extracts from Piper aduncum L. in Alternative in vitro and in vivo Control of Phytopathogens of Agronomical Interest
Hexane Extracts from Piper aduncum L. in Alternative in vitro and in vivo Control of Phytopathogens of Agronomical Interest Open
View article: Anticancer Activity of 4-Aryl-1,4-Dihydropyridines
Anticancer Activity of 4-Aryl-1,4-Dihydropyridines Open
We have synthesized 22 symmetric and asymmetric 4-aryl-1,4-dihydropyridines (1,4-DHPs) by a “green” microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their cytotoxicity to three human cancer cell lines regarding U-2…
View article: In Vitro and In Silico Studies of the Antimicrobial Activity of Prenylated Phenylpropanoids of Green Propolis and Their Derivatives against Oral Bacteria
In Vitro and In Silico Studies of the Antimicrobial Activity of Prenylated Phenylpropanoids of Green Propolis and Their Derivatives against Oral Bacteria Open
Artepillin C, drupanin, and plicatin B are prenylated phenylpropanoids that naturally occur in Brazilian green propolis. In this study, these compounds and eleven of their derivatives were synthesized and evaluated for their in vitro antim…
View article: Chemical composition and antimycobacterial, anti- <i>Malassezia furfur</i> and cytotoxic activities of essential oils from <i>Callistemon viminalis</i> (Sol. ex Gaertn.) G. Don leaves and flowers
Chemical composition and antimycobacterial, anti- <i>Malassezia furfur</i> and cytotoxic activities of essential oils from <i>Callistemon viminalis</i> (Sol. ex Gaertn.) G. Don leaves and flowers Open
Callistemon viminalis has been widely known due to its therapeutic properties. Tuberculosis is a deadly infectious disease caused predominantly by Mycobacterium tuberculosis. Other respiratory diseases may also be caused by n…
View article: Isolation of 8 ß -hydroxy-goyazensanolide from Eremanthus argenteus and the complete and unequivocal 1H and 13C NMR data assignment for this sesquiterpene lactone
Isolation of 8 ß -hydroxy-goyazensanolide from Eremanthus argenteus and the complete and unequivocal 1H and 13C NMR data assignment for this sesquiterpene lactone Open
This work describes the first isolation of 8 ß-hydroxy-goyazensanolide from Eremanthus argenteus and the complete and unequivocal 1H and 13C NMR assignments for this compound. The assignments were carried out in the means of spectroscopic …
View article: Stereoselective oxidative coupling of methyl trans-ferulate by Trametes versicolor
Stereoselective oxidative coupling of methyl trans-ferulate by Trametes versicolor Open
Chemoenzymatic strategies for synthesizing complex molecules have been raised by combining biocatalytic and synthetic methods in a multistep approach toward a target molecule. Dihydrobenzofuran neolignans (DBNs) are a class of plant-derive…
View article: Antibacterial and antileishmanial activity of 1,4-dihydropyridine derivatives
Antibacterial and antileishmanial activity of 1,4-dihydropyridine derivatives Open
We have synthesized twenty-three 1,4-dihydropyridine derivatives (1,4-DHPs) by using a microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their antibacterial activity against a representative panel of cariogenic bact…
View article: Front Cover: <i>In vitro</i> Evaluation of the Antileishmanial and Antischistosomal Activities of <i>p</i>‐Coumaric Acid Prenylated Derivatives (Chem. Biodiversity 5/2024)
Front Cover: <i>In vitro</i> Evaluation of the Antileishmanial and Antischistosomal Activities of <i>p</i>‐Coumaric Acid Prenylated Derivatives (Chem. Biodiversity 5/2024) Open
Front Cover. In the quest for alternative therapies to treat leishmaniasis and schistosomiasis, two of the main Neglected Tropical Diseases, the screening of synthetic natural product-inspired compounds emerges as a viable strategy. In the…
View article: Chemical composition, antileishmanial, and antifungal activi-ties of essential oils from Cinnamomum cassia bark, Schinus molle dried leaves and their blends
Chemical composition, antileishmanial, and antifungal activi-ties of essential oils from Cinnamomum cassia bark, Schinus molle dried leaves and their blends Open
This study reports on the chemical composition and antileishmanial and anticandidal activities of essential oils (EOs) distilled from Schinus molle dried leaves (SM-EO), Cinnamomum cassia branch bark (CC-EO) and their blends against promas…
View article: In vitro evaluation of the antiparasitic activity of p-coumaric acid prenylated derivatives
In vitro evaluation of the antiparasitic activity of p-coumaric acid prenylated derivatives Open
We have evaluated eight p-coumaric acid prenylated derivatives in vitro for their antileishmanial activity against Leishmania amazonensis promastigotes and their antischistosomal activity against Schistosoma mansoni adult worms. Compound 7…
View article: Electrospray ionization tandem mass spectrometry of 4-aryl-3,4-dihydrocoumarins
Electrospray ionization tandem mass spectrometry of 4-aryl-3,4-dihydrocoumarins Open
We have investigated the gas-phase fragmentation reactions of eleven synthetic 4-aryl-3,4-dihydrocoumarins by electrospray ionization tandem mass spectrometry (ESI-MS/MS) on a quadrupole-time-of flight (Q-TOF) hybrid mass spectrometer. We …
View article: Monoketone Curcuminoids: An Updated Review of Their Synthesis and Biological Activities
Monoketone Curcuminoids: An Updated Review of Their Synthesis and Biological Activities Open
Curcumin (or diferuloylmethane), a component of Curcuma longa L. rhizomes, displays various biological and pharmacological activities. However, it is poorly bioavailable and unstable in physiological pH. In this review, we cover papers pub…
View article: In vitro and in silico studies of prenylated phenylpropanoids of green propolis and their derivatives against cariogenic bacteria
In vitro and in silico studies of prenylated phenylpropanoids of green propolis and their derivatives against cariogenic bacteria Open
Artepillin C, drupanin, and plicatin B are prenylated phenylpanoids naturally occurring in Brazilian green propolis. In this study, these compounds and eleven derivatives were synthesized and evaluated for their in vitro antimicrobial acti…
View article: Volatile compounds of hexane extract from <i>Pterodon pubescens</i> Benth seeds and its significant <i>in vitro</i> potential against different bacterial strains
Volatile compounds of hexane extract from <i>Pterodon pubescens</i> Benth seeds and its significant <i>in vitro</i> potential against different bacterial strains Open
Pterodon pubescens Benth is a Brazilian medicinal plant (sucupira, in Brazilian Portuguese). This paper aims to determine the volatile composition and antibacterial activities of hexane extract from P. pubescens seeds …
View article: Functional characterisation of <i>Euglena gracilis</i> following growth medium enrichment
Functional characterisation of <i>Euglena gracilis</i> following growth medium enrichment Open
In recent years, microalgae, particularly Euglena gracilis, have been candidates for the food/feed industry thanks to their nutritional and functional properties. However, the inclusion of E. gracilis in the diet of livestock animals is li…
View article: Monoketone Curcuminoids: An Updated Review of Their Synthesis and Biological Activities
Monoketone Curcuminoids: An Updated Review of Their Synthesis and Biological Activities Open
Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione], a component of Curcuma longa L. rhizomes, displays various biological and pharmacological activities. However, it is poorly bioavailable and unstable in physiological p…
View article: Evaluation of the in vitro antischistosomal activity of Bidens sulphurea (Cav.) Sch. Bip. (Asteraceae)
Evaluation of the in vitro antischistosomal activity of Bidens sulphurea (Cav.) Sch. Bip. (Asteraceae) Open
In this study, the in vitro schistosomicidal properties of the n-hexane (BS-1), dichlorometane (BS-2) and methanol (BS-3) extracts from the leaves of Bidens sulphurea against Schistosoma mansoni were investigated. The extract BS-3 at 200 µ…
View article: Exploring Synthetic Dihydrobenzofuran and Benzofuran Neolignans as Antiprotozoal Agents against Trypanosoma cruzi
Exploring Synthetic Dihydrobenzofuran and Benzofuran Neolignans as Antiprotozoal Agents against Trypanosoma cruzi Open
Chagas disease is a neglected tropical disease that affects more than 8 million people. Although there are therapies against this disease, the search for new drugs is important because the current treatments show limited effectiveness and …
View article: Total Phenolic Content and Antioxidant Activity of In Vitro Digested Hemp-Based Products
Total Phenolic Content and Antioxidant Activity of In Vitro Digested Hemp-Based Products Open
The growth of the world population has prompted research to investigate new food/feed alternatives. Hemp-based products can be considered excellent candidates. Hemp (Cannabis sativa L.) is an environmentally sustainable plant widespread wo…
View article: Bioactive Hexane Extracts from Piper aduncum and Xylopia aromatica Against Bacterial Strains which Cause Food Poisoning
Bioactive Hexane Extracts from Piper aduncum and Xylopia aromatica Against Bacterial Strains which Cause Food Poisoning Open
Plants and their extracts have been used as natural antimicrobial agents in food products as a strategy to mitigate food contamination.Therefore, this study aimed to determine the chemical composition of hexane extracts from Piper aduncum …