Antonio Francesco Campese
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View article: BH3 mimetic drugs overcome the microenvironment-induced resistance to crizotinib in ALK+ anaplastic large cell lymphoma
BH3 mimetic drugs overcome the microenvironment-induced resistance to crizotinib in ALK+ anaplastic large cell lymphoma Open
Resistance to first-line chemotherapies and crizotinib in anaplastic large cell lymphoma (ALCL) represents a significant challenge, often leading to a dismal outcome. Despite recent advancements, the dissection of the intrinsic and extrins…
View article: Notch Inhibitors and BH3 Mimetics in T-Cell Acute Lymphoblastic Leukemia
Notch Inhibitors and BH3 Mimetics in T-Cell Acute Lymphoblastic Leukemia Open
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with poor response to conventional therapy, derived from hematopoietic progenitors committed to T-cell lineage. Relapsed/Refractory patients account for …
View article: The NF-κB1/p50 Subunit Influences the Notch/IL-6-Driven Expansion of Myeloid-Derived Suppressor Cells in Murine T-Cell Acute Lymphoblastic Leukemia
The NF-κB1/p50 Subunit Influences the Notch/IL-6-Driven Expansion of Myeloid-Derived Suppressor Cells in Murine T-Cell Acute Lymphoblastic Leukemia Open
T-cell acute lymphoblastic leukemia is an aggressive neoplasia due to hyper-proliferation of lymphoid progenitors and lacking a definitive cure to date. Notch-activating mutations are the most common in driving disease onset and progressio…
View article: Correction: Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL
Correction: Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL Open
View article: Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL
Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL Open
View article: Evaluation of the Therapeutic Effects of Harmine on Anaplastic Thyroid Cancer Cells
Evaluation of the Therapeutic Effects of Harmine on Anaplastic Thyroid Cancer Cells Open
Anaplastic thyroid carcinoma (ATC) is an extremely difficult disease to tackle, with an overall patient survival of only a few months. The currently used therapeutic drugs, such as kinase inhibitors or immune checkpoint inhibitors, can pro…
View article: Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL
Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL Open
Malignant transformation of T-cell progenitors causes T-cell acute lymphoblastic leukemia (T-ALL), an aggressive childhood lymphoproliferative disorder. Activating mutations of Notch1 and overexpression of Notch3, as well as rare Notch3 ac…
View article: Notch-Signaling Deregulation Induces Myeloid-Derived Suppressor Cells in T-Cell Acute Lymphoblastic Leukemia
Notch-Signaling Deregulation Induces Myeloid-Derived Suppressor Cells in T-Cell Acute Lymphoblastic Leukemia Open
Notch receptors deeply influence T-cell development and differentiation, and their dysregulation represents a frequent causative event in “T-cell acute lymphoblastic leukemia” (T-ALL). “Myeloid-derived suppressor cells” (MDSCs) inhibit hos…
View article: CD44v8-10 is a marker for malignant traits and a potential driver of bone metastasis in a subpopulation of prostate cancer cells
CD44v8-10 is a marker for malignant traits and a potential driver of bone metastasis in a subpopulation of prostate cancer cells Open
CD44v8-10 could represent a marker of a more aggressive bone metastatic PC population exerting a driver role in osteomimicry in bone. A novel link between TAZ and CD44v8-10 is also shown.
View article: Exogenous peptides are able to penetrate human cell and mitochondrial membranes, stabilize mitochondrial tRNA structures, and rescue severe mitochondrial defects
Exogenous peptides are able to penetrate human cell and mitochondrial membranes, stabilize mitochondrial tRNA structures, and rescue severe mitochondrial defects Open
Mutations in mitochondrial transfer RNA (mt‐tRNA) genes are responsible for a wide range of syndromes, for which no effective treatment is available. We previously reported that transfection of the nucleotide sequence encoding for the 16‐r…
View article: NF-κB1 Regulates Immune Environment and Outcome of Notch-Dependent T-Cell Acute Lymphoblastic Leukemia
NF-κB1 Regulates Immune Environment and Outcome of Notch-Dependent T-Cell Acute Lymphoblastic Leukemia Open
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive pediatric malignancy that arises from the transformation of immature T-cell progenitors and has no definitive cure. Notch signaling governs many steps of T cell development and i…
View article: Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer
Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer Open
The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-κB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological condit…
View article: Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation
Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation Open
View article: Stem-like and highly invasive prostate cancer cells expressing CD44v8-10 marker originate from CD44-negative cells
Stem-like and highly invasive prostate cancer cells expressing CD44v8-10 marker originate from CD44-negative cells Open
In human prostate cancer (PCa), the neuroendocrine cells, expressing the prostate cancer stem cell (CSC) marker CD44, may be resistant to androgen ablation and promote tumor recurrence. During the study of heterogeneity of the highly aggre…
View article: PO-393 Notch3 and CXCR4 cross-signalling sustains acute T-cell leukaemia progression
PO-393 Notch3 and CXCR4 cross-signalling sustains acute T-cell leukaemia progression Open
and SMART technology, in conjunction with two novel nextgeneration sequencing (NGS) library preparation kits, using the same primer pairs, to capture full-length variable regions of TCR-a and -b chains.Material and methods Method 1, using …
View article: NOTCH1 Is Aberrantly Activated in Chronic Lymphocytic Leukemia Hematopoietic Stem Cells
NOTCH1 Is Aberrantly Activated in Chronic Lymphocytic Leukemia Hematopoietic Stem Cells Open
To investigate chronic lymphocytic leukemia (CLL)-initiating cells, we assessed NOTCH1 mutation/expression in hematopoietic stem cells (HSCs). In NOTCH1-mutated CLL, we detected subclonal mutations in 57% CD34+/CD38- HSCs.
View article: A non-conserved amino acid variant regulates differential signalling between human and mouse CD28
A non-conserved amino acid variant regulates differential signalling between human and mouse CD28 Open
CD28 superagonistic antibodies (CD28SAb) can preferentially activate and expand immunosuppressive regulatory T cells (Treg) in mice. However, pre-clinical trials assessing CD28SAbs for the therapy of autoimmune diseases reveal severe syste…
View article: The mazy case of Notch and immunoregulatory cells
The mazy case of Notch and immunoregulatory cells Open
The Notch pathway represents a conserved signal transduction machinery that is straightforward and based on a few elements (ligands, receptors, transducers). However, the existence of multiple control levels of the Notch signaling final ou…
View article: Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression
Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression Open
View article: Short peptides from leucyl-tRNA synthetase rescue disease-causing mitochondrial tRNA point mutations
Short peptides from leucyl-tRNA synthetase rescue disease-causing mitochondrial tRNA point mutations Open
Mutations in mitochondrial (mt) genes coding for mt-tRNAs are responsible for a range of syndromes, for which no effective treatment is available. We recently showed that the carboxy-terminal domain (Cterm) of human mt-leucyl tRNA syntheta…
View article: Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β
Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β Open
The Notch1 and Notch4 signaling pathways regulate endothelial cell homeostasis. Inflammatory cytokines induce the expression of endothelial adhesion molecules, including VCAM1, partly by downregulating Notch4 signaling. We investigated the…
View article: Targeting estrogen receptor β as preventive therapeutic strategy for Leber's hereditary optic neuropathy
Targeting estrogen receptor β as preventive therapeutic strategy for Leber's hereditary optic neuropathy Open
Leber's hereditary optic neuropathy (LHON) is a maternally inherited blinding disease characterized by degeneration of retinal ganglion cells (RGCs) and consequent optic nerve atrophy. Peculiar features of LHON are incomplete penetrance an…
View article: Epstein-Barr virus infection induces miR-21 in terminally differentiated malignant B cells
Epstein-Barr virus infection induces miR-21 in terminally differentiated malignant B cells Open
The association of Epstein-Barr virus (EBV) with plasmacytoid malignancies is now well established but how the virus influences microRNA expression in such cells is not known. We have used multiple myeloma (MM) cell lines to address this i…