Antonio Frandi
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View article: HdaB: a novel and conserved DnaA-related protein that targets the RIDA process to stimulate replication initiation
HdaB: a novel and conserved DnaA-related protein that targets the RIDA process to stimulate replication initiation Open
Exquisite control of the DnaA initiator is critical to ensure that bacteria initiate chromosome replication in a cell cycle-coordinated manner. In many bacteria, the DnaA-related and replisome-associated Hda/HdaA protein interacts with Dna…
View article: HdaB: a novel and conserved DnaA-related protein that targets the RIDA process to stimulate replication initiation
HdaB: a novel and conserved DnaA-related protein that targets the RIDA process to stimulate replication initiation Open
Exquisite control of the DnaA initiator is critical to ensure that bacteria initiate chromosome replication in a cell cycle-coordinated manner. In many bacteria, the DnaA-related and replisome-associated Hda/HdaA protein interacts with Dna…
View article: Multilayered control of chromosome replication in <i>Caulobacter crescentus</i>
Multilayered control of chromosome replication in <i>Caulobacter crescentus</i> Open
The environmental Alphaproteobacterium Caulobacter crescentus is a classical model to study the regulation of the bacterial cell cycle. It divides asymmetrically, giving a stalked cell that immediately enters S phase and a swarmer cell tha…
View article: Control of proline utilization by the Lrp-like regulator PutR in Caulobacter crescentus
Control of proline utilization by the Lrp-like regulator PutR in Caulobacter crescentus Open
Cellular metabolism recently emerged as a central player modulating the bacterial cell cycle. The Alphaproteobacterium Caulobacter crescentus appears as one of the best models to study these connections, but its metabolism is still poorly …
View article: Mutational likeliness and entropy help to identify driver mutations and their functional role in cancer
Mutational likeliness and entropy help to identify driver mutations and their functional role in cancer Open
Alterations in cancer genomes originate from mutational processes taking place throughout oncogenesis and cancer progression. We show that likeliness and entropy are two properties of somatic mutations crucial in cancer evolution, as cance…
View article: Cell Cycle Constraints and Environmental Control of Local DNA Hypomethylation in α-Proteobacteria
Cell Cycle Constraints and Environmental Control of Local DNA Hypomethylation in α-Proteobacteria Open
Heritable DNA methylation imprints are ubiquitous and underlie genetic variability from bacteria to humans. In microbial genomes, DNA methylation has been implicated in gene transcription, DNA replication and repair, nucleoid segregation, …
View article: Cell Cycle Constraints and Environmental Control of Local DNA Hypomethylation in α-Proteobacteria
Cell Cycle Constraints and Environmental Control of Local DNA Hypomethylation in α-Proteobacteria Open
Heritable DNA methylation imprints are ubiquitous and underlie genetic variability from bacteria to humans. In microbial genomes, DNA methylation has been implicated in gene transcription, DNA replication and repair, nucleoid segregation, …
View article: Regulatory (pan-)genome of an obligate intracellular pathogen in the PVC superphylum
Regulatory (pan-)genome of an obligate intracellular pathogen in the PVC superphylum Open
Like other obligate intracellular bacteria, the Chlamydiae feature a compact regulatory genome that remains uncharted owing to poor genetic tractability. Exploiting the reduced number of transcription factors (TFs) encoded in the chlamydia…