Antonio López-Beltrán
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View article: Artificial intelligence in prostate cancer
Artificial intelligence in prostate cancer Open
Prostate cancer (PCa) ranks as the second most prevalent malignancy among men worldwide. Early diagnosis, personalized treatment, and prognosis prediction of PCa play a crucial role in improving patients’ survival rates. The advancement of…
View article: Digital and computational transition in the pathology lab: when did it start?
Digital and computational transition in the pathology lab: when did it start? Open
View article: Membranous urethral length is the single independent predictor of urinary continence recovery at 12 months following Retzius-sparing robot-assisted radical prostatectomy
Membranous urethral length is the single independent predictor of urinary continence recovery at 12 months following Retzius-sparing robot-assisted radical prostatectomy Open
View article: Validation of a urine- based proteomics test to predict clinically significant prostate cancer: complementing MRI pathway
Validation of a urine- based proteomics test to predict clinically significant prostate cancer: complementing MRI pathway Open
Purpose Prostate cancer (PCa) is the most frequently diagnosed cancer in men. One major clinical need is to accurately predict clinically significant PCa (csPCa). A proteomics based 19-biomarker model (19-BM) was previously developed using…
View article: Validation of diagnostic nomograms based on mass spectrometry-based urinary biomarkers to distinguish clinically significant prostate cancer: complementing MRI pathway
Validation of diagnostic nomograms based on mass spectrometry-based urinary biomarkers to distinguish clinically significant prostate cancer: complementing MRI pathway Open
View article: Corrigendum to “Proposal for a Novel Histological Scoring System as a Potential Grading Approach for Muscle-invasive Urothelial Bladder Cancer Correlating with Disease Aggressiveness and Patient Outcomes” [European Urology Oncology (2023)]
Corrigendum to “Proposal for a Novel Histological Scoring System as a Potential Grading Approach for Muscle-invasive Urothelial Bladder Cancer Correlating with Disease Aggressiveness and Patient Outcomes” [European Urology Oncology (2023)] Open
The authors regret that the author 'Maurizio Colecchia' was not included in the author list. This has now been corrected as above. The authors would like to apologise for any inconvenience caused. Proposal for a Novel Histological Scoring …
View article: Proposal for a Novel Histological Scoring System as a Potential Grading Approach for Muscle-invasive Urothelial Bladder Cancer Correlating with Disease Aggressiveness and Patient Outcomes
Proposal for a Novel Histological Scoring System as a Potential Grading Approach for Muscle-invasive Urothelial Bladder Cancer Correlating with Disease Aggressiveness and Patient Outcomes Open
We developed a novel approach to assess the aggressiveness of advanced bladder cancer, which allows improved risk stratification compared with the method currently proposed by the World Health Organization.
View article: International Opinions on Grading of Urothelial Carcinoma: A Survey Among European Association of Urology and International Society of Urological Pathology Members
International Opinions on Grading of Urothelial Carcinoma: A Survey Among European Association of Urology and International Society of Urological Pathology Members Open
View article: Supplementary Data from Susceptibility Perturbation MRI Maps Tumor Infiltration into Mesorectal Lymph Nodes
Supplementary Data from Susceptibility Perturbation MRI Maps Tumor Infiltration into Mesorectal Lymph Nodes Open
Figure S1. Raw data from MGE MRI on a representative patient in-vivo at 1.5 T.
View article: Data from Identification of PMF1 Methylation in Association with Bladder Cancer Progression
Data from Identification of PMF1 Methylation in Association with Bladder Cancer Progression Open
Purpose: Polyamines are important regulators of cell growth and death. The polyamine modulated factor-1 (PMF-1) is involved in polyamine homeostasis. After identifying an enriched CpG island encompassing the PMF1 promoter, we aimed …
View article: Data from Susceptibility Perturbation MRI Maps Tumor Infiltration into Mesorectal Lymph Nodes
Data from Susceptibility Perturbation MRI Maps Tumor Infiltration into Mesorectal Lymph Nodes Open
Noninvasive characterization of lymph node involvement in cancer is an enduring onerous challenge. In rectal cancer, pathologic lymph node status constitutes the most important determinant of local recurrence and overall survival, and pati…
View article: Data from Identification of PMF1 Methylation in Association with Bladder Cancer Progression
Data from Identification of PMF1 Methylation in Association with Bladder Cancer Progression Open
Purpose: Polyamines are important regulators of cell growth and death. The polyamine modulated factor-1 (PMF-1) is involved in polyamine homeostasis. After identifying an enriched CpG island encompassing the PMF1 promoter, we aimed …
View article: Supplementary Data from Susceptibility Perturbation MRI Maps Tumor Infiltration into Mesorectal Lymph Nodes
Supplementary Data from Susceptibility Perturbation MRI Maps Tumor Infiltration into Mesorectal Lymph Nodes Open
Figure S1. Raw data from MGE MRI on a representative patient in-vivo at 1.5 T.
View article: Supplementary Data from Identification of PMF1 Methylation in Association with Bladder Cancer Progression
Supplementary Data from Identification of PMF1 Methylation in Association with Bladder Cancer Progression Open
Supplementary Data from Identification of PMF1 Methylation in Association with Bladder Cancer Progression
View article: Supplementary Data from Identification of PMF1 Methylation in Association with Bladder Cancer Progression
Supplementary Data from Identification of PMF1 Methylation in Association with Bladder Cancer Progression Open
Supplementary Data from Identification of PMF1 Methylation in Association with Bladder Cancer Progression
View article: Data from Susceptibility Perturbation MRI Maps Tumor Infiltration into Mesorectal Lymph Nodes
Data from Susceptibility Perturbation MRI Maps Tumor Infiltration into Mesorectal Lymph Nodes Open
Noninvasive characterization of lymph node involvement in cancer is an enduring onerous challenge. In rectal cancer, pathologic lymph node status constitutes the most important determinant of local recurrence and overall survival, and pati…
View article: Retzius-sparing robot-assisted radical prostatectomy in a medium size oncological center holds adequate oncological and functional outcomes
Retzius-sparing robot-assisted radical prostatectomy in a medium size oncological center holds adequate oncological and functional outcomes Open
View article: News in the classification of WHO 2022 bladder tumors
News in the classification of WHO 2022 bladder tumors Open
The 2022 World Health Organization (WHO) Classification of Tumors of the Urinary System and Male Genital Organs represents an update in classification on urinary tract tumors. It also offers new insights with regards to the grading of hete…
View article: 355 TCR γδ+ TIL from patients with pancreatic cancer recognize autologous tumor cells restricted by CD1d
355 TCR γδ+ TIL from patients with pancreatic cancer recognize autologous tumor cells restricted by CD1d Open
Background Pancreatic cancer is the 7th leading cause of cancer-related deaths worldwide. Treatment options are still limited; immunotherapeutic approaches using tumor infiltrating lymphocytes (TIL) represent a viable option for PDAC patie…
View article: 961 Tumor-infiltrating mucosal-associated invariant T cells (MAIT) from patients with pancreatic cancer recognize shared tumor antigens in an MR1-restricted fashion
961 Tumor-infiltrating mucosal-associated invariant T cells (MAIT) from patients with pancreatic cancer recognize shared tumor antigens in an MR1-restricted fashion Open
Background Pancreatic adenocarcinoma (PDAC) is one of the most lethal cancers with a 5-year survival rate of 10%.1 Standard chemotherapeutics have failed to produce relevant increased survival for patients with pancreatic cancer…
View article: The most effective but largely ignored target for prostate cancer early detection and intervention
The most effective but largely ignored target for prostate cancer early detection and intervention Open
Over the past two decades, the global efforts for the early detection and intervention of prostate cancer seem to have made significant progresses in the basic researches, but the clinic outcomes have been disappointing: (1) prostate cance…
View article: Targeting Neoepitopes to Treat Solid Malignancies: Immunosurgery
Targeting Neoepitopes to Treat Solid Malignancies: Immunosurgery Open
Successful outcome of immune checkpoint blockade in patients with solid cancers is in part associated with a high tumor mutational burden (TMB) and the recognition of private neoantigens by T-cells. The quality and quantity of target recog…
View article: Lesson from the COVID-19 pandemic: pathologists need to build their confidence on working in a digital microscopy environment
Lesson from the COVID-19 pandemic: pathologists need to build their confidence on working in a digital microscopy environment Open
View article: Safety and Efficacy of Virtual Prostatectomy With Single-Dose Radiotherapy in Patients With Intermediate-Risk Prostate Cancer
Safety and Efficacy of Virtual Prostatectomy With Single-Dose Radiotherapy in Patients With Intermediate-Risk Prostate Cancer Open
ClinicalTrials.gov Identifier: NCT02570919.
View article: Telomerase reverse transcriptase (TERT) promoter mutations in primary adenocarcinoma of bladder and urothelial carcinoma with glandular differentiation: pathogenesis and diagnostic implications
Telomerase reverse transcriptase (TERT) promoter mutations in primary adenocarcinoma of bladder and urothelial carcinoma with glandular differentiation: pathogenesis and diagnostic implications Open
View article: Towards a new WHO classification of renal cell tumor: what the clinician needs to know—a narrative review
Towards a new WHO classification of renal cell tumor: what the clinician needs to know—a narrative review Open
In 1952, renal cell carcinomas had been divided into 2 categories-clear cell or granular cell-depending upon their cytoplasmic staining characteristics. In the following years, the inventory of renal epithelial tumors has expanded by the a…
View article: Digital diagnostics and artificial intelligence in prostate cancer treatment in 5 years from now
Digital diagnostics and artificial intelligence in prostate cancer treatment in 5 years from now Open
Digital diagnostics and artificial intelligence in prostate cancer treatment in 5 years from nowThe range of novelties included in this special series on "Update on molecular classification and individualized treatments of genitourinary tu…
View article: TNM staging towards a personalized approach in metastatic urothelial carcinoma: what will the future be like?—a narrative review
TNM staging towards a personalized approach in metastatic urothelial carcinoma: what will the future be like?—a narrative review Open
The American Joint Committee of Cancer (AJCC) tumor-node-metastasis (TNM) classification, with its periodical updates and modifications, has represented and still represents the basis of cancer staging. The historical, long-standing limita…
View article: Adjuvant therapy in renal cell carcinoma: is it the right strategy to inhibit VEGF?
Adjuvant therapy in renal cell carcinoma: is it the right strategy to inhibit VEGF? Open
Despite several clinical trials have assessed different agents in the adjuvant setting, renal cell carcinoma (RCC) still remains a disease orphan of an effective adjuvant treatment. In fact, systemic therapies targeting angiogenesis that h…
View article: Narrative review of prostate cancer grading systems: will the Gleason scores be replaced by the Grade Groups?
Narrative review of prostate cancer grading systems: will the Gleason scores be replaced by the Grade Groups? Open
The Gleason grading system, proposed by Dr. Donald F. Gleason in 1966, is one of the most important prognostic factors in men with prostate cancer (PCa). At consensus conferences held in 2005 and 2014, organized by the International Societ…