Francisco A. Macı́as
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View article: Metabolite Screening From <scp> <i>Pinus pinea</i> </scp> Needles Reveals (+)‐Isocupressic Acid as a Key Phytotoxin for Weed Management
Metabolite Screening From <span> <i>Pinus pinea</i> </span> Needles Reveals (+)‐Isocupressic Acid as a Key Phytotoxin for Weed Management Open
Introduction Weeds are a major threat to crop productivity, competing for essential resources and often developing resistance to herbicides, which underscores the need for novel, sustainable control strategies. The valorization of agricult…
View article: Exploring Sesquiterpene Lactones from Saussurea lappa: Isolation, Structural Modifications, and Herbicide Bioassay Evaluation
Exploring Sesquiterpene Lactones from Saussurea lappa: Isolation, Structural Modifications, and Herbicide Bioassay Evaluation Open
Considering the resistance of weeds to different herbicides with different mechanisms of action, the search for new, more selective compounds with low toxicity to other species in nature has been very important for the development of agric…
View article: Biological activities of hydroxyanthracene derivatives (HADs) from Aloe species and their potential uses
Biological activities of hydroxyanthracene derivatives (HADs) from Aloe species and their potential uses Open
Hydroxyanthracene derivatives (HADs) are a class of naturally occurring organic compounds known for their diverse biological activities and applications. Due to their pharmacological versatility, hydroxyanthracene derivatives represent a m…
View article: VANET Network Simulation for Greenhouse Monitoring Utilizing Two Mobile Differential Robot Nodes
VANET Network Simulation for Greenhouse Monitoring Utilizing Two Mobile Differential Robot Nodes Open
Monitoring the greenhouse environment is crucial for regulating physical variables such as temperature, humidity, CO2 concentration and luminosity. VANET (Vehicular Ad-hoc Network) represents a particular case of multi-hop wireless network…
View article: Ginger Phytotoxicity: Potential Efficacy of Extracts, Metabolites and Derivatives for Weed Control
Ginger Phytotoxicity: Potential Efficacy of Extracts, Metabolites and Derivatives for Weed Control Open
The negative implications for weeds encourage the finding of novel sources of phytotoxic agents for sustainable management. While traditional herbicides are effective, especially at large scales, the environmental impact and proliferation …
View article: Phytotoxic Activity of Sesquiterpene Lactones-Enriched Fractions from Cynara cardunculus L. Leaves on Pre-Emergent and Post-Emergent Weed Species and Putative Mode of Action
Phytotoxic Activity of Sesquiterpene Lactones-Enriched Fractions from Cynara cardunculus L. Leaves on Pre-Emergent and Post-Emergent Weed Species and Putative Mode of Action Open
Sesquiterpene lactones (SLs) are compounds that are highly produced in Cynara cardunculus leaves, known for their phytotoxic activity. This study aims to assess SL-enriched fractions’ (cynaropicrin, aguerin B, and grosheimin) phytotoxic po…
View article: Dereplication of New Saponins from Agave bracteosa
Dereplication of New Saponins from Agave bracteosa Open
The genus Agave comprises over 400 species that are known for their diverse applications, which include being sources of fiber, food, and beverages. There has recently been increased interest in exploring the metabolic content of this genu…
View article: Dereplication of Bioactive <i>Agave</i> Saponin Fractions: The Hidden Saponins
Dereplication of Bioactive <i>Agave</i> Saponin Fractions: The Hidden Saponins Open
The good phytotoxicity and selectivity against weeds versus tomato or cress make saponin-rich fractions from Agave macroacantha, A. colorata, A. parryi, and A. parrasana attractive candidates as bioherbicides. The saponin contents have onl…
View article: Bioprospection of Phytotoxic Plant-Derived Eudesmanolides and Guaianolides for the Control of <i>Amaranthus viridis</i>, <i>Echinochloa crus-galli</i>, and <i>Lolium perenne</i> Weeds
Bioprospection of Phytotoxic Plant-Derived Eudesmanolides and Guaianolides for the Control of <i>Amaranthus viridis</i>, <i>Echinochloa crus-galli</i>, and <i>Lolium perenne</i> Weeds Open
The phytotoxicities of a selection of eudesmanolides and guaianolides, including natural products and new derivatives obtained by semisynthesis from plant-isolated sesquiterpene lactones, were evaluated in bioassays against three weeds of …
View article: Microwave-Assisted Rearrangement of Costunolide Catalyzed by Palladium(II)
Microwave-Assisted Rearrangement of Costunolide Catalyzed by Palladium(II) Open
The structure of costunolide was modified before conducting the Cope rearrangement under thermal conditions. This modification was undertaken to block the highly reactive Michael acceptor α-methylene-γ-lactone, thus preventing side reactio…
View article: Effects of Sesquiterpene Lactones on Primary Cilia Formation (Ciliogenesis)
Effects of Sesquiterpene Lactones on Primary Cilia Formation (Ciliogenesis) Open
Sesquiterpene lactones (SLs), plant-derived metabolites with broad spectra of biological effects, including anti-tumor and anti-inflammatory, hold promise for drug development. Primary cilia, organelles extending from cell surfaces, are cr…
View article: Allelopathic studies with furanocoumarins isolated from Ducrosia anethifolia. In vitro and in silico investigations to protect legumes, rice and grain crops
Allelopathic studies with furanocoumarins isolated from Ducrosia anethifolia. In vitro and in silico investigations to protect legumes, rice and grain crops Open
Six different furanocoumarins were isolated from the aerial parts of Ducrosia anethifolia and tested in vitro for plant cell elongation in etiolated wheat coleoptile. They were also tested for their ability to control three different weeds…
View article: Perspectives and Advances in Organic Formulations for Agriculture: Encapsulation of Herbicides for Weed Control
Perspectives and Advances in Organic Formulations for Agriculture: Encapsulation of Herbicides for Weed Control Open
This article offers a critical analysis of the evolution of encapsulation methods for herbicides and natural products, with a main focus on organic formulations. It extols the possibilities presented by these micro- and nanomaterials, such…
View article: Synthesis of Benzoxazinones Sulphur Analogs and Their Application as Bioherbicides: 1.4-Benzothiazinones and 1.4-Benzoxathianones for Weed Control
Synthesis of Benzoxazinones Sulphur Analogs and Their Application as Bioherbicides: 1.4-Benzothiazinones and 1.4-Benzoxathianones for Weed Control Open
Eight different compounds inspired by benzoxazinones were synthesized in one simple step with easy purification. These compounds have a sulfur atom instead of the oxygen atom present in benzoxazinones. Furthermore, a new derivative obtaine…
View article: Biological Activity of Naphthoquinones Derivatives in the Search of Anticancer Lead Compounds
Biological Activity of Naphthoquinones Derivatives in the Search of Anticancer Lead Compounds Open
Naphthoquinones are a valuable source of secondary metabolites that are well known for their dye properties since ancient times. A wide range of biological activities have been described highlighting their cytotoxic activity, gaining the a…
View article: Wheat Response and Weed-Suppressive Ability in the Field Application of a Nanoencapsulated Disulfide (DiS-NH2) Bioherbicide Mimic
Wheat Response and Weed-Suppressive Ability in the Field Application of a Nanoencapsulated Disulfide (DiS-NH2) Bioherbicide Mimic Open
Improving the efficacy of bioherbicides to overcome weed resistance phenomena is one of the main challenges within agriculture. Organic encapsulation is attracting attention as an alternative and eco-friendly tool, mainly in organic farmin…
View article: Synthesis of Aminophenoxazinones and Evaluation of Their Phytotoxicity in the Search for New Natural Herbicides
Synthesis of Aminophenoxazinones and Evaluation of Their Phytotoxicity in the Search for New Natural Herbicides Open
Natural products have been postulated as an alternative to the use of synthetic herbicides in pest control. The latter compounds have caused numerous problems and these include the appearance of resistance to such herbicides. Aminophenoxaz…
View article: Host–guest complexation of phthalimide-derived strigolactone mimics with cyclodextrins. Application in agriculture against parasitic weeds
Host–guest complexation of phthalimide-derived strigolactone mimics with cyclodextrins. Application in agriculture against parasitic weeds Open
A study proposing cyclodextrins as eco-friendly compounds to enhance the physicochemical properties of phthalimide-lactones to produce complexes inducing the germination of parasitic weeds even without using organic co-solvents.
View article: Stability and p<i>K</i><sub>a</sub> Modulation of Aminophenoxazinones and Their Disulfide Mimics by Host–Guest Interaction with Cucurbit[7]uril. Direct Applications in Agrochemical Wheat Models
Stability and p<i>K</i><sub>a</sub> Modulation of Aminophenoxazinones and Their Disulfide Mimics by Host–Guest Interaction with Cucurbit[7]uril. Direct Applications in Agrochemical Wheat Models Open
Aqueous solubility and stability often limit the application of aminophenoxazinones and their sulfur mimics as promising agrochemicals in a sustainable agriculture inspired by allelopathy. This paper presents a solution to the problem usin…
View article: On the formulation of disulfide herbicides based on aminophenoxazinones: polymeric nanoparticle formulation and cyclodextrin complexation to combat crop yield losses
On the formulation of disulfide herbicides based on aminophenoxazinones: polymeric nanoparticle formulation and cyclodextrin complexation to combat crop yield losses Open
Background The resistance of weeds to herbicides is a significant issue in ensuring future food supply. Specific examples are Plantago lanceolata, Portulaca oleracea and Lolium rigidum , which mainly infect rice, wheat, barley and pastures…
View article: Computational discovery of novel anthelmintic natural compounds from Agave Brittoniana trel. Spp. Brachypus
Computational discovery of novel anthelmintic natural compounds from Agave Brittoniana trel. Spp. Brachypus Open
Helminth infections are a medical problem in the world nowadays. This report used bond-based 2D quadratic indices, a bond-level QuBiLs-MAS molecular descriptor family, and Linear Discriminant Analysis (LDA) to obtain a quantitative linear …
View article: Steroidal Saponins with Plant Growth Stimulation Effects; Yucca schidigera as a Commercial Source
Steroidal Saponins with Plant Growth Stimulation Effects; Yucca schidigera as a Commercial Source Open
Plant growth-stimulation bioactivity of triterpenoid saponins is well known, especially for oleanane-type compounds. Nevertheless, a few phytotoxicity bioassays performed on some steroidal saponins have shown hormesis profiles and growth s…
View article: In Silico Evaluation of Sesquiterpenes and Benzoxazinoids Phytotoxins against Mpro, RNA Replicase and Spike Protein of SARS-CoV-2 by Molecular Dynamics. Inspired by Nature
In Silico Evaluation of Sesquiterpenes and Benzoxazinoids Phytotoxins against Mpro, RNA Replicase and Spike Protein of SARS-CoV-2 by Molecular Dynamics. Inspired by Nature Open
In the work described here, a number of sesquiterpenes and benzoxazinoids from natural sources, along with their easily accessible derivatives, were evaluated against the main protease, RNA replicase and spike glycoprotein of SARS-CoV-2 by…
View article: Evaluation of the phytotoxic and antifungal activity of <scp>C<sub>17</sub></scp>‐sesquiterpenoids as potential biopesticides
Evaluation of the phytotoxic and antifungal activity of <span>C<sub>17</sub></span>‐sesquiterpenoids as potential biopesticides Open
BACKGROUND Natural products are a promising source for the development of new pesticides with alternative mechanisms of action. In this study, we evaluated the phytotoxic and antifungal activity of a novel family of natural C 17 ‐sesquiter…
View article: Encapsulation of Cynara Cardunculus Guaiane-type Lactones in Fully Organic Nanotubes Enhances Their Phytotoxic Properties
Encapsulation of Cynara Cardunculus Guaiane-type Lactones in Fully Organic Nanotubes Enhances Their Phytotoxic Properties Open
The encapsulation of bioactive natural products has emerged as a relevant tool for modifying the poor physicochemical properties often exhibited by agrochemicals. In this regard, natural guaiane-type sesquiterpene lactones isolated from Cy…
View article: Agave Steroidal Saponins as Potential Bioherbicides
Agave Steroidal Saponins as Potential Bioherbicides Open
Agave saponins are a valuable resource for the prospective development of new forms of agrochemicals. The extraction method was optimized and applied to 17 Agave species. Thirteen saponin fractions (SFs) were assayed on wheat etiolated col…