Explanipedia

The phenomenology of psilocybin: transformative insights for research and clinical practice Open

Antonio Metastasio, Elisabeth Prevete, Sofia Venturini, Andrea Garofalo, Beatrice Cecconello , et al. · 2025

Introduction Considering the increasing evidence supporting psilocybin’s efficacy in therapeutic settings, it is essential to deepen our understanding of its subjective meanings and effects to enhance its integration into psychotherapy. Cu…

“Youth 2.0 project”: Multi-professional Intervention to Protect Adolescents from NPS and Other Drug Use Open

Valentina Rapaccini, S. Biscontini, Annette M. Molinaro, Giovanni Loreto, Augusto Pasini , et al. · 2024

Introduction: The COVID 19 pandemic has significantly affected the consumption of drugs determining a substantial increase in psychiatric discomfort and mental illness, especially among youth. Our study focuses the attention on Terni, a ci…

Illicit COVID-19 products online: A mixed-method approach for identifying and preventing online health risks Open

Valeria Catalani, Honor D. Townshend, Mariya Prilutskaya, Robert P. Chilcott, Antonio Metastasio , et al. · 2023

Aims The COVID-19 pandemic triggered a demand for vaccines, cures, and the need of related documentation for travel, work and other purposes. Our project aimed to identify the illicit availability of such products across the Dark Web Marke…

Increased violence and aggression levels during the SARS-Cov-2 pandemic; data from three London acute psychiatric inpatient facilities. Open

S. Bonaccorso, Olesya Ajnakina, A Ricciardi, Sophie Ouabbou, Jenna M. Wilson , et al. · 2023

Introduction The COVID-19 pandemic has significantly impacted mental health services, with the literature reporting an increase in the incidence of psychiatric admissions. Objectives The aim of this study was to assess the impact of the pa…

A phenomenological analysis of Fellini's films to understand the effect of LSD therapy on his creativity Open

Antonio Metastasio, Silvio Mignogna, Riccardo Paci, Milena Mancini, Fabio Melelli , et al. · 2023

Since its discovery in 1943, LSD has been used by artists, scientists, and intellectuals, amongst others, to stimulate their creative insights. Federico Fellini, one of the most important film directors in the XX century, used LSD when it …

Implementation of individualised polygenic risk score analysis: a test case of a family of four Open

Manuel Corpas, Karyn Mégy, Antonio Metastasio, Edmund Lehmann · 2022

Addiction of High Dose of Benzodiazepine: Verona Detox Approach With Flumazenil Open

Rebecca Casari, Antonio Metastasio, Lorenzo Zamboni, Martino Biasioli, Simone Campagnari , et al. · 2022

Introduction Since the 1990s there has been evidence of the significant role Flumazenil (FLU) has in benzodiazepines (BZD) detoxes. The Verona Detox approach has been developed for high dose BZD and Z-drug detoxification via continuous sub…

Implementation of Individualised Polygenic Risk Score Analysis: A Test Case of a Family of Four Open

Manuel Corpas, Karyn Mégy, Antonio Metastasio, Edmund Lehmann · 2021

Polygenic risk scores (PRS) have been widely applied in research studies, showing how population groups can be stratified into risk categories for many common conditions. As healthcare systems consider applying PRS to keep their population…

Neutropenia in patients under treatment with clozapine and COVID-19 infection Open

S. Bonaccorso, A Ricciardi, Sophie Ouabbou, Christos Theleritis, Arabella Ross-Michaelides , et al. · 2021

Introduction Clozapine is among the most effective antipsychotics used for treatment resistant schizophrenia. Adverse reactions to clozapine include neutropenia. Case series report that clozapine-treated patients with COVID-19 have no docu…

Whole Genome Interpretation for a Family of Five Open

Manuel Corpas, Karyn Mégy, Vanisha Mistry, Antonio Metastasio, Edmund Lehmann · 2021

Although best practices have emerged on how to analyse and interpret personal genomes, the utility of whole genome screening remains underdeveloped. A large amount of information can be gathered from various types of analyses via whole gen…

Clozapine, neutropenia and Covid-19: should clinicians be concerned? 3 months report Open

Stefania Bonaccorso, A Ricciardi, Sophie Ouabbou, Christos Theleritis, Arabella Ross-Michaelides , et al. · 2021

Clinicians should bear in mind that a significant drop in neutrophils' count may occur in patients taking clozapine and affected from a SARS-CoV-2 infectionand that this drop is only transitory.

Can Kratom (Mitragyna speciosa) Alleviate COVID-19 Pain? A Case Study Open

Antonio Metastasio, Elisabeth Prevete, Darshan Singh, Oliver Grundmann, Walter C. Prozialeck , et al. · 2020

Among the symptoms of COVID-19 fever, general malaise, pain and aches, myalgia, fatigue, and headache can affect the quality of life of patients, even after the end of the acute phase of the infection and can be long lasting. The current t…

Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study Open

Aravinthan Varatharaj, Naomi Thomas, Mark Ellul, Nicholas Davies, Thomas Pollak , et al. · 2020

Novel Psychoactive Substances in Custodial Settings: A Mixed Method Investigation on the Experiences of People in Prison and Professionals Working With Them Open

Ornella Corazza, Sara Coloccini, Shanna Marrinan, M. Vigar, Caryl Watkins , et al. · 2020

Findings highlight the urgent need for joint multi-disciplinary efforts to tackle the exponential escalation of NPS in prisons as well as to facilitate the recovery and societal reintegration of those affected. Phenomenology can be recomme…

Synthetic Cannabinoid use in a Case Series of Patients with Psychosis Presenting to Acute Psychiatric Settings: Clinical Presentation and Management Issues Open

Stefania Bonaccorso, Antonio Metastasio, A Ricciardi, Neil Stewart, Leila Jamal , et al. · 2018

Background: Novel Psychoactive Substances (NPS) are a heterogeneous class of synthetic molecules including synthetic cannabinoid receptor agonists (SCRAs). Psychosis is associated with SCRAs use. There is limited knowledge regarding the st…

Transitioning Bodies. The Case of Self-Prescribing Sexual Hormones in Gender Affirmation in Individuals Attending Psychiatric Services Open

Antonio Metastasio, Attilio Negri, Giovanni Martinotti, Ornella Corazza · 2018

Self-prescribing of sexual hormones for gender affirmation is a potentially widespread and poorly studied phenomenon that many clinicians are unaware of. The uncontrolled use of hormones poses significant health hazards, which have not bee…

Erratum: Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence Open

Anna Murphy, Liam J. Nestor, John McGonigle, Louise M. Paterson, Venkataramana Boyapati , et al. · 2017

Erratum: Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence Open

Anna Murphy, Liam J. Nestor, John McGonigle, Louise M. Paterson, Venkataramana Boyapati , et al. · 2017

Correction to: Neuropsychopharmacology advance online publication, 25 January 2017; doi:10.1038/npp.2016.289 This article was originally published under SN's License to Publish, but has now been made available under a CC BY 4.0 license. Th…

Ethnic Minority Status, Age-at-Immigration and Psychosis Risk in Rural Environments: Evidence From the SEPEA Study Open

James B. Kirkbride, Yasir Hameed, Konstantinos Ioannidis, Gayatri Ankireddypalli, Carolyn M Crane , et al. · 2017

$\textbf{Objective}$: Several ethnic minority groups experience elevated rates of first-episode psychosis (FEP), but most studies have been conducted in urban settings. We investigated whether incidence varied by ethnicity, generation stat…

Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence Open

Anna Murphy, Liam J. Nestor, John McGonigle, Louise M. Paterson, Venkataramana Boyapati , et al. · 2017

The Epidemiology of First-Episode Psychosis in Early Intervention in Psychosis Services: Findings From the Social Epidemiology of Psychoses in East Anglia [SEPEA] Study Open

James B. Kirkbride, Yasir Hameed, Gayatri Ankireddypalli, Konstantinos Ioannidis, Carolyn M Crane , et al. · 2016

OBJECTIVE: Few studies have characterized the epidemiology of first-episode psychoses in rural or urban settings since the introduction of early intervention psychosis services. To address this, the authors conducted a naturalistic cohort …

Impulsivity in abstinent alcohol and polydrug dependence: a multidimensional approach Open

Eleanor Taylor, Anna Murphy, Venkat Boyapati, Karen D. Ersche, Remy Flechais , et al. · 2016

Abnormal Frontostriatal Activity During Unexpected Reward Receipt in Depression and Schizophrenia: Relationship to Anhedonia Open

Núria Segarra, Antonio Metastasio, Hisham Ziauddeen, Jennifer Spencer, Niels R. Reinders , et al. · 2015

Reduction in ventral striatal activity when anticipating a reward in depression and schizophrenia: a replicated cross-diagnostic finding Open

Gonzalo Arrondo, Núria Segarra, Antonio Metastasio, Hisham Ziauddeen, Jennifer Spencer , et al. · 2015

In the research domain framework (RDoC), dysfunctional reward expectation has been proposed to be a cross-diagnostic domain in psychiatry, which may contribute to symptoms common to various neuropsychiatric conditions, such as anhedonia or…

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