Antonio Saviano YOU? Author Swipe

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Plasma Exchange as potential treatment of Severe Immune Checkpoint Inhibitor-Induced Hepatitis Open

Clément Monet, Antonio Saviano, Marwin A. Farrugia, Marion Khaldi, Olivier Moranne , et al. · 2025

Improving immunotherapy for the treatment of hepatocellular carcinoma: learning from patients and preclinical models Open

Romain Désert, Fabio Gianonne, Antonio Saviano, Yujin Hoshida, Mathias Heikenwälder , et al. · 2025

Hepatocellular carcinoma (HCC), the third cause of cancer-related deaths worldwide, continues to present significant therapeutic challenges. Despite significant therapeutic advancement in the last decade, the efficacy of systemic treatment…

A patient-derived HCC spheroid system to model the tumor microenvironment and treatment response Open

Émilie Crouchet, Nuno Almeida, Sarah Durand, Marie Parnot, Marine A. Oudot , et al. · 2024

Targeting the liver clock improves fibrosis by restoring TGF-β signaling Open

Émilie Crouchet, Mayssa Dachraoui, Frank Jühling, Natascha Roehlen, Marine A. Oudot , et al. · 2024

Single-cell RNA-sequencing of virus-specific cellular immune responses in chronic hepatitis B patients Open

Klas Hatje, Tony Kam‐Thong, Nicolas Giroud, Antonio Saviano, Pauline Simo‐Noumbissie , et al. · 2024

HBV Immunomics Smart-seq2 data Open

Klas Hatje, Tony Kam‐Thong, Nicolas Giroud, Antonio Saviano, Pauline Simo‐Noumbissie , et al. · 2023

Here, we established a single-cell RNA-sequencing (scRNA-seq) dataset of HBV immune responses in patients to contribute to a better understanding of the dysregulated immune response in CHB. We collected blood samples of a well-defined coho…

HBV Immunomics 10X data Open

Klas Hatje, Tony Kam‐Thong, Nicolas Giroud, Antonio Saviano, Pauline Simo‐Noumbissie , et al. · 2023

Here, we established a single-cell RNA-sequencing (scRNA-seq) dataset of HBV immune responses in patients to contribute to a better understanding of the dysregulated immune response in CHB. We collected blood samples of a well-defined coho…

HBV Immunomics 10X and Smart-seq2 integrated data Open

Klas Hatje, Tony Kam‐Thong, Nicolas Giroud, Antonio Saviano, Pauline Simo‐Noumbissie , et al. · 2023

Here, we established a single-cell RNA-sequencing (scRNA-seq) dataset of HBV immune responses in patients to contribute to a better understanding of the dysregulated immune response in CHB. We collected blood samples of a well-defined coho…

HBV Immunomics Smart-seq2 data Open

Klas Hatje, Tony Kam‐Thong, Nicolas Giroud, Antonio Saviano, Pauline Simo‐Noumbissie , et al. · 2023

Here, we established a single-cell RNA-sequencing (scRNA-seq) dataset of HBV immune responses in patients to contribute to a better understanding of the dysregulated immune response in CHB. We collected blood samples of a well-defined coho…

HBV Immunomics 10X and Smart-seq2 integrated data Open

Klas Hatje, Tony Kam‐Thong, Nicolas Giroud, Antonio Saviano, Pauline Simo‐Noumbissie , et al. · 2023

Here, we established a single-cell RNA-sequencing (scRNA-seq) dataset of HBV immune responses in patients to contribute to a better understanding of the dysregulated immune response in CHB. We collected blood samples of a well-defined coho…

HBV Immunomics 10X data Open

Klas Hatje, Tony Kam‐Thong, Nicolas Giroud, Antonio Saviano, Pauline Simo‐Noumbissie , et al. · 2023

Here, we established a single-cell RNA-sequencing (scRNA-seq) dataset of HBV immune responses in patients to contribute to a better understanding of the dysregulated immune response in CHB. We collected blood samples of a well-defined coho…

A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity Open

Natascha Roehlen, Antonio Saviano, Houssein El Saghire, Émilie Crouchet, Zeina Nehme , et al. · 2022

Tissue fibrosis is a key driver of end-stage organ failure and cancer, overall accounting for up to 45% of deaths in developed countries. There is a large unmet medical need for antifibrotic therapies. Claudin-1 (CLDN1) is a member of the …

Treatment of HCC with claudin-1-specific antibodies suppresses carcinogenic signaling and reprograms the tumor microenvironment Open

Natascha Roehlen, Marion Müller, Zeina Nehme, Émilie Crouchet, Frank Jühling , et al. · 2022

An impossible biliary drainage? Fistulization of a degenerated intraductal papillary mucinous pancreatic neoplasm to the common bile duct Open

Pierre Mayer, Lucile Héroin, Leonardo Sosa-Valencia, Flavien Dautrecque, Patrick Pessaux , et al. · 2022

Intraductal papillary mucinous pancreatic neoplasms (IPMNs) are very common lesions. International guidelines recommend surveillance or more invasive management according to precise criteria [1]. A very rare complication of these lesions i…

Safety and Antiviral Activity of EGFR Inhibition by Erlotinib in Chronic Hepatitis C Patients: A Phase Ib Randomized Controlled Trial Open

Antonio Saviano, François Habersetzer, Joachim Lupberger, Pauline Simo‐Noumbissie, Catherine Schuster , et al. · 2022

INTRODUCTION: Significant hepatocellular carcinoma (HCC) risk persists after chronic hepatitis C (CHC) cure. Preclinical studies have shown that erlotinib, an oral epidermal growth factor receptor (EGFR) inhibitor, has an antiviral activit…

Differences between sporadic hyperplastic gastric polyps and portal hypertensive gastric polyps: a review Open

Lucile Héroin, Antonio Saviano, Tanguy Fenouil, Leonardo Sosa-Valencia, Thomas F. Baumert , et al. · 2022

Portal hypertension (PH) is one of the most severe complications of chronic liver diseases. It is defined as an increase in pressure in the portal venous system which results in a portosystemic gradient >5 mmHg. In the western world, cirrh…

Conventional and artificial intelligence-based imaging for biomarker discovery in chronic liver disease Open

Jérémy Dana, Aïna Venkatasamy, Antonio Saviano, Joachim Lupberger, Yujin Hoshida , et al. · 2022

Hepatitis C treatment in patients with substance use disorder: the faster the better Open

Antonio Saviano, Lucile Héroin, Pierre Mayer, Thomas F. Baumert · 2022

Current evidence on the beneficial properties of Lactobacillus species in lactose intolerance Open

Mattia Brigida, Antonio Saviano, Giovanni De Carlo, Andrea Piccioni, V. Ojetti · 2021

Objectives: Lactose intolerance (LI) is a condition characterized by absent or strongly decreased levels of intestinal lactase. This is a key enzyme for the lactose hydrolysis to monosaccharides, glucose, and galactose. Colonic bacteria me…

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery Open

Émilie Crouchet, Simonetta Bandiera, Naoto Fujiwara, Shen Li, Hussein El Saghire , et al. · 2021

Hepatitis B virus compartmentalization and single-cell differentiation in hepatocellular carcinoma Open

Frank Juehling, Antonio Saviano, Clara Ponsolles, Laura Heydmann, Émilie Crouchet , et al. · 2021

Chronic hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma (HCC) world-wide. The molecular mechanisms of viral hepatocarcinogenesis are still partially understood. Here, we applied two complementary single-cell …

Unraveling the role of liver sinusoidal endothelial cells in COVID-19 liver injury Open

Antonio Saviano, Thomas F. Baumert · 2021

Cannabidiol and the central nervous system: translating into clinics Open

Antonio Saviano, F. Raucci, Martina Tallarico, Carmen De, Stefania Martino , et al. · 2021

Cannabis plants contain more than a hundred cannabinoids of which we have only limited knowledge about their effects and exact mechanisms of action.Cannabidiol (CBD) represents one of the most studied; it was discovered at the beginning of…

A Robust and Simple Patient-derived Multicellular Spheroid Model Enables Liver Cancer Precision Drug Screening Open

Sara Cherradi, Nuno Almeida, Antonio Saviano, Sarah Durand, Emanuele Felli , et al. · 2021

Background & Purpose. Hepatocellular carcinoma (HCC) is the second leading and fastest rising cause of cancer death worldwide. HCC is often diagnosed when it is not curable. Thus, there are many challenges associated with the treatment of …

13C urea breath test to identify Helicobacter pylori Infection in patients with upper gastrointestinal bleeding admitted to the Emergency Department. Open

Veronica Ojetti, Antonio Saviano, Carmine Petruzziello, Mattia Brigida, Giulia Pignataro , et al. · 2021

Our study confirms that the use of UBT directly in ED in patients with UGIB allows for a rapid, reliable and non-invasive diagnosis of HP infection as a causative agent for bleeding, thus permitting a right etiological treatment.

Liver Disease and Coronavirus Disease 2019: From Pathogenesis to Clinical Care Open

Antonio Saviano, Florian Wrensch, Marc G. Ghany, Thomas F. Baumert · 2020

Infection with the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a novel coronavirus that emerged in late 2019, is posing an unprecedented challenge to global health. Coronavirus disease 2019 (COVID‐19), the clinical diseas…

Risk Factors, Pathogenesis, and Strategies for Hepatocellular Carcinoma Prevention: Emphasis on Secondary Prevention and Its Translational Challenges Open

Li Shen, Antonio Saviano, Derek J. Erstad, Yujin Hoshida, Bryan C. Fuchs , et al. · 2020

Hepatocellular carcinoma (HCC) is a leading cause of cancer-associated mortality globally. Given the limited therapeutic efficacy in advanced HCC, prevention of HCC carcinogenesis could serve as an effective strategy. Patients with chronic…

FIB-4 score and hepatocellular carcinoma risk after hepatitis C virus cure: time to revise surveillance? Open

Antonio Saviano, Simona Tripon, Thomas F. Baumert · 2020

PMC7603928 uniform disclosure form (available at http://dx.doi.org/10.21037/hbsn.2020.01.05). The authors have no conflicts of interest to declare.

A human liver cell-based system modeling a clinical prognostic liver signature combined with single cell RNA-seq for discovery of novel liver disease therapeutics Open

Émilie Crouchet, Simonetta Bandiera, Naoto Fujiwara, Shen Li, Hussein El Saghire , et al. · 2020

Viral compartmentalization and carcinogenesis at single-cell level in HBV-induced hepatocellular carcinoma Open

Antonio Saviano, Frank Jühling, Éloi R. Verrier, Hussein El Saghire, Laura Heydmann , et al. · 2020

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