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View article: Agitation in Alzheimer’s disease: From assessment to therapeutics
Agitation in Alzheimer’s disease: From assessment to therapeutics Open
Agitation is a neuropsychiatric syndrome characterized by excessive motor and/or verbal behaviors, with or without aggressive behaviors. The prevalence of agitation in Alzheimer’s disease varies from 5% to over 50%. Multiple factors have b…
View article: In silico prediction of the impact of genomic variations in the small conductance calcium activated potassium channel SK3 structure and function
In silico prediction of the impact of genomic variations in the small conductance calcium activated potassium channel SK3 structure and function Open
The small-conductance calcium-activated potassium channel SK3, encoded by the KCNN3 gene, plays a critical role in regulating dopaminergic neuron (DN) firing patterns by modulating after hyperpolarization currents. SK3 dysfunction has been…
View article: Changes in Traumatic Brain Injury Patterns Before and During the COVID-19 Pandemic: A Single-Center Study in Brazil
Changes in Traumatic Brain Injury Patterns Before and During the COVID-19 Pandemic: A Single-Center Study in Brazil Open
View article: USO DO ÓLEO ESSENCIAL DA AROEIRA COMO ALTERNATIVA TERAPÊUTICA
USO DO ÓLEO ESSENCIAL DA AROEIRA COMO ALTERNATIVA TERAPÊUTICA Open
View article: Improving adherence to physical activity in treatment-resistant depression: Protocol for a pilot randomized controlled trial of a remotely delivered program
Improving adherence to physical activity in treatment-resistant depression: Protocol for a pilot randomized controlled trial of a remotely delivered program Open
Background At least 30% of individuals with major depressive disorder do not respond to conventional treatments (i.e., they meet the criteria for treatment-resistant depression [TRD]). Alternative therapeutic modalities are needed. Some st…
View article: RECURSOS TECNOLÓGICOS E FAZER PEDAGÓGICO NA EDUCAÇÃO ESPECIAL
RECURSOS TECNOLÓGICOS E FAZER PEDAGÓGICO NA EDUCAÇÃO ESPECIAL Open
O presente trabalho teve como intuito entender sobre o uso de recursos tecnológicos e o fazer pedagógico na educação especial. A pergunta norteadora da pesquisa foi a reflexão sobre inclusão digital e o fazer pedagógico com alunos deficien…
View article: Quantity and Quality Matter: Different Neuroanatomical Substrates of Apathy in Alzheimer’s Disease and Behavioural Variant Frontotemporal Dementia
Quantity and Quality Matter: Different Neuroanatomical Substrates of Apathy in Alzheimer’s Disease and Behavioural Variant Frontotemporal Dementia Open
Background: Apathy is almost ubiquitous across neurodegenerative diseases and can be a general model for understanding neuropsychiatric symptoms in dementia. Methods: We assessed apathy via Starkstein’s Apathy Scale—caregiver version (SAS-…
View article: Persistent cognitive symptoms in mild COVID-19 infection: a retrospective cohort study
Persistent cognitive symptoms in mild COVID-19 infection: a retrospective cohort study Open
Approximately one-third of patients with COVID-19, mainly women and people infected during the second wave of infection, experienced persistent cognitive symptoms.
View article: Does Midbrain Atrophy Distinguish Progressive Supranuclear Palsy from Frontotemporal Dementia?
Does Midbrain Atrophy Distinguish Progressive Supranuclear Palsy from Frontotemporal Dementia? Open
Background The diagnostic value of midbrain atrophy for distinguishing behavioral variant frontotemporal dementia (bvFTD) from progressive supranuclear palsy (PSP) is unclear. Objective To investigate whether measures of midbrain atrophy d…
View article: Long sleep duration, cognitive performance, and the moderating role of depression: A cross‐sectional analysis in the Framingham Heart Study
Long sleep duration, cognitive performance, and the moderating role of depression: A cross‐sectional analysis in the Framingham Heart Study Open
INTRODUCTION We investigated whether depression modified the associations between sleep duration and cognitive performance. METHODS We examined the associations between sleep duration and cognition in 1853 dementia‐and‐stroke‐free particip…
View article: Protective effects of psychiatric medications against COVID-19 mortality before vaccines
Protective effects of psychiatric medications against COVID-19 mortality before vaccines Open
The coronavirus disease pandemic caused by the coronavirus SARS-CoV-2, which emerged in the United States in late 2019 to early 2020 and quickly escalated into a national public health crisis. Research has identified psychiatric conditions…
View article: Cardiovascular disease and bipolar disorder: A review of pathophysiology and treatment implications
Cardiovascular disease and bipolar disorder: A review of pathophysiology and treatment implications Open
Objective Despite the well-established increased risk of cardiovascular mortality in individuals with bipolar disorder (BD), prevention and treatment of cardiovascular risk factors and diseases have been largely overlooked in this populati…
View article: Redescobrindo Hélio Pellegrino nos 100 anos de seu nascimento
Redescobrindo Hélio Pellegrino nos 100 anos de seu nascimento Open
View article: Brain‐Derived Neurotrophic Factor (BDNF) as a Potential Biomarker in Brain Glioma: A Systematic Review and Meta‐Analysis
Brain‐Derived Neurotrophic Factor (BDNF) as a Potential Biomarker in Brain Glioma: A Systematic Review and Meta‐Analysis Open
Background This systematic review and meta‐analysis evaluates peripheral and CNS BDNF levels in glioma patients. Methods Following PRISMA guidelines, we systematically searched databases for studies measuring BDNF in glioma patients and co…
View article: Do subclinical anxious and depressive symptoms affect facial emotion recognition? An exploratory investigation
Do subclinical anxious and depressive symptoms affect facial emotion recognition? An exploratory investigation Open
Emotion recognition is a key component of social cognition. Symptoms of depression and anxiety may modulate this ability. Objective: To investigate the effect of subclinical depressive and anxiety symptoms on performance in a facial emotio…
View article: Immunopsychiatry of late life depression: role of ageing-related immune/inflammatory processes in the development and progression of depression
Immunopsychiatry of late life depression: role of ageing-related immune/inflammatory processes in the development and progression of depression Open
Background: Late-life depression (LLD) arises from a complex interplay among biological, psychological, and social factors. Biologically, three main hypotheses have been proposed to explain the distinct clinical features of LLD. The vascul…
View article: Digital transformation in public accounting and finance management: A clusters literature review
Digital transformation in public accounting and finance management: A clusters literature review Open
This study investigates the literary corpus on the role and potential of digital transformation in public accounting and finance management. A total of 890 research papers was extracted from Scopus and Web of Science for bibliometric analy…
View article: Social functioning in bipolar disorder: investigating the role played by comorbid physical illnesses and cognition
Social functioning in bipolar disorder: investigating the role played by comorbid physical illnesses and cognition Open
Bipolar disorder (BD) is a psychiatric disorder associated with functioning and cognitive impairments, as well as a higher prevalence of physical disease comorbidities. Objective: To determine the main predictors of functioning in patients…
View article: The conundrum of the connection between severe psychiatric disorders and dementia
The conundrum of the connection between severe psychiatric disorders and dementia Open
Psychiatric disorders have been recognized as important risk factors for neurodegenerative diseases, especially dementia. The strength of association varies among different psychiatric conditions, being more pronounced in severe mental ill…
View article: Preclinical evaluation of immunogenicity and protective efficacy of a recombinant chimeric protein vaccine against visceral leishmaniasis
Preclinical evaluation of immunogenicity and protective efficacy of a recombinant chimeric protein vaccine against visceral leishmaniasis Open
Visceral leishmaniasis (VL) is a tropical disease that can be fatal if acute and untreated. Diagnosis is difficult, the treatment is toxic and prophylactic vaccines do not exist. Leishmania parasites express hundreds of proteins and severa…
View article: ESTRATÉGIA DE ENSINO PARA APRIMORAMENTO AO EXAME-FÍSICO PULMONAR EM ENFERMAGEM
ESTRATÉGIA DE ENSINO PARA APRIMORAMENTO AO EXAME-FÍSICO PULMONAR EM ENFERMAGEM Open
View article: Protective Effects of Psychiatric Medications against COVID-19 Mortality Before Vaccines
Protective Effects of Psychiatric Medications against COVID-19 Mortality Before Vaccines Open
Objectives: To investigate the relationship between neuropsychiatric medication usage and COVID-19 outcomes before COVID-19 usage. Methods: This cross-sectional study used Optum’s de-identified Clinformatics® Data Mart Database to identify…
View article: Clinical features of Chagas disease progression and severity
Clinical features of Chagas disease progression and severity Open
View article: Physical comorbidities of older age bipolar disorder (OABD) patients: A global replication analysis of prevalence and sex differences
Physical comorbidities of older age bipolar disorder (OABD) patients: A global replication analysis of prevalence and sex differences Open
View article: Genetic ablation of the isoform γ of PI3K decreases antidepressant efficacy of ketamine in male mice
Genetic ablation of the isoform γ of PI3K decreases antidepressant efficacy of ketamine in male mice Open
View article: Post-COVID-19 cognitive symptoms in patients assisted by a teleassistance service: a retrospective cohort study
Post-COVID-19 cognitive symptoms in patients assisted by a teleassistance service: a retrospective cohort study Open
Introduction Four years after the onset of the COVID-19 pandemic, the frequency of long-term post-COVID-19 cognitive symptoms is a matter of concern given the impact it may have on the work and quality of life of affected people. Objective…
View article: Cognition in older age bipolar disorder: An analysis of archival data across the globe
Cognition in older age bipolar disorder: An analysis of archival data across the globe Open
View article: Bipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project
Bipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project Open
Objectives The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE‐BD) project pools archival datasets on older age bipolar disorder (OABD). An initial Wave 1 (W1; n = 1369) analysis found both manic and depressive symp…
View article: Peripheral Levels of the Brain-Derived Neurotrophic Factor in Coronary Artery Disease: A Systematic Review and Meta-Analysis
Peripheral Levels of the Brain-Derived Neurotrophic Factor in Coronary Artery Disease: A Systematic Review and Meta-Analysis Open
Background: Among its functions, brain-derived neurotrophic factor (BDNF) regulates endothelial and macrophage activation, possibly playing a role in atherosclerotic plaque pathophysiology. Given contradicting reports, this study sought to…
View article: Neuropsychiatric sequelae in an experimental model of post-COVID syndrome in mice
Neuropsychiatric sequelae in an experimental model of post-COVID syndrome in mice Open
The global impact of the COVID-19 pandemic has been unprecedented, and presently, the world is facing a new challenge known as Post-COVID syndrome (PCS). Current estimates suggest that more than 65 million people are grappling with PCS, en…