Antonios M. Makris
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View article: Magnesium Hydroxide Microparticle Treatment Potently Inhibits Venturia oleaginea Pathogenesis on Olives
Magnesium Hydroxide Microparticle Treatment Potently Inhibits Venturia oleaginea Pathogenesis on Olives Open
Olive trees worldwide suffer from a number of devastating fungal diseases that affect production. One such serious disease is olive leaf spot caused by Venturia oleaginea. Recently, we applied magnesium hydroxide porous micron-scale partic…
View article: Chemical and transcriptomic analyses of leaf trichomes from <i>Cistus creticus</i> subsp. <i>creticus</i> reveal the biosynthetic pathways of certain labdane-type diterpenoids and their acetylated forms
Chemical and transcriptomic analyses of leaf trichomes from <i>Cistus creticus</i> subsp. <i>creticus</i> reveal the biosynthetic pathways of certain labdane-type diterpenoids and their acetylated forms Open
Labdane-related diterpenoids (LRDs), a subgroup of terpenoids, exhibit structural diversity and significant commercial and pharmacological potential. LRDs share the characteristic decalin–labdanic core structure that derives from the cyclo…
View article: The Value of Negative Urinary Dipstick Tests for Haematuria in Patients Undergoing Surveillance for Low-grade Ta Urothelial Cancer: A Two-stage Prospective Clinical Study in 524 Patients
The Value of Negative Urinary Dipstick Tests for Haematuria in Patients Undergoing Surveillance for Low-grade Ta Urothelial Cancer: A Two-stage Prospective Clinical Study in 524 Patients Open
We investigated the accuracy of a dipstick test for blood in the urine for patients undergoing surveillance for low-grade noninvasive bladder cancer. We found that a negative dipstick test result was highly associated with the absence of t…
View article: Identification and Construction of Strong Promoters in Yarrowia lipolytica Suitable for Glycerol-Based Bioprocesses
Identification and Construction of Strong Promoters in Yarrowia lipolytica Suitable for Glycerol-Based Bioprocesses Open
Yarrowia lipolytica is a non-pathogenic aerobic yeast with numerous industrial biotechnology applications. The organism grows in a wide variety of media, industrial byproducts, and wastes. A need exists for molecular tools to improve heter…
View article: The TΑp63/BCL2 axis represents a novel mechanism of clinical aggressiveness in chronic lymphocytic leukemia
The TΑp63/BCL2 axis represents a novel mechanism of clinical aggressiveness in chronic lymphocytic leukemia Open
The TA-isoform of the p63 transcription factor (TAp63) has been reported to contribute to clinical aggressiveness in chronic lymphocytic leukemia (CLL) in a hitherto elusive way. Here, we sought to further understand and define the role of…
View article: Antifouling Activity of Halogenated Compounds Derived from the Red Alga Sphaerococcus coronopifolius: Potential for the Development of Environmentally Friendly Solutions
Antifouling Activity of Halogenated Compounds Derived from the Red Alga Sphaerococcus coronopifolius: Potential for the Development of Environmentally Friendly Solutions Open
Nowadays, biofouling is responsible for enormous economic losses in the maritime sector, and its treatment with conventional antifouling paints is causing significant problems to the environment. Biomimetism and green chemistry approaches …
View article: <i>RPS15</i> mutations rewire RNA translation in chronic lymphocytic leukemia
<i>RPS15</i> mutations rewire RNA translation in chronic lymphocytic leukemia Open
Recent studies of chronic lymphocytic leukemia (CLL) have reported recurrent mutations in the RPS15 gene, which encodes the ribosomal protein S15 (RPS15), a component of the 40S ribosomal subunit. Despite some evidence about the role of mu…
View article: Effects of Magnesium Oxide and Magnesium Hydroxide Microparticle Foliar Treatment on Tomato PR Gene Expression and Leaf Microbiome
Effects of Magnesium Oxide and Magnesium Hydroxide Microparticle Foliar Treatment on Tomato PR Gene Expression and Leaf Microbiome Open
Recently, metal oxides and magnesium hydroxide nanoparticles (NPs) with high surface-to-volume ratios were shown to possess antibacterial properties with applications in biomedicine and agriculture. To assess recent observations from field…
View article: “Cerberus” T Cells: A Glucocorticoid-Resistant, Multi-Pathogen Specific T Cell Product to Fight Infections in Severely Immunocompromised Patients
“Cerberus” T Cells: A Glucocorticoid-Resistant, Multi-Pathogen Specific T Cell Product to Fight Infections in Severely Immunocompromised Patients Open
Adoptive immunotherapy (AI) with pathogen-specific T cells is a promising alternative to pharmacotherapy for the treatment of opportunistic infections after allogeneic hematopoietic cell transplantation or solid organ transplantation. Howe…
View article: Analysis of Microbial Community Dynamics during the Acclimatization Period of a Membrane Bioreactor Treating Table Olive Processing Wastewater
Analysis of Microbial Community Dynamics during the Acclimatization Period of a Membrane Bioreactor Treating Table Olive Processing Wastewater Open
Biological treatment of table olive processing wastewater (TOPW) may be problematic due to its high organic and polyphenolic compound content. Biomass acclimatization is a necessary, yet sensitive, stage for efficient TOPW biological treat…
View article: PS1207 DEVELOPING A CRISPR‐CAS9 TOOL TO INACTIVATE THE GLUCOCORTICOID RECEPTOR AND BROADEN THE APPLICABILITY OF ANTIGEN‐SPECIFIC T‐CELL IMMUNOTHERAPY
PS1207 DEVELOPING A CRISPR‐CAS9 TOOL TO INACTIVATE THE GLUCOCORTICOID RECEPTOR AND BROADEN THE APPLICABILITY OF ANTIGEN‐SPECIFIC T‐CELL IMMUNOTHERAPY Open
Background: Viral and fungal infections are among the most fatal complications in patients undergoing allogeneic hematopoietic stem cell transplantation (allo‐HSCT). While pharmacotherapy often fails or is associated with toxicity, adoptiv…
View article: Biochemical Fingerprint of Greek Sideritis spp.: Implications for Potential Drug Discovery and Advanced Breeding Strategies
Biochemical Fingerprint of Greek Sideritis spp.: Implications for Potential Drug Discovery and Advanced Breeding Strategies Open
Plant species of the Sideritis genus are native to the Mediterranean region and widely used through millennia for their medicinal and culinary properties. They are mostly known as mountain tea or Shepard tea and in the last few years, they…
View article: Isoprenoid biosynthesis in the diatom <i>Haslea ostrearia</i>
Isoprenoid biosynthesis in the diatom <i>Haslea ostrearia</i> Open
Summary Diatoms are eukaryotic, unicellular algae that are responsible for c . 20% of the Earth's primary production. Their dominance and success in contemporary oceans have prompted investigations on their distinctive metabolism and physi…
View article: <i>Tp53</i>gene p72R polymorphism in chronic lymphocytic leukemia: incidence and clinical significance amongst cases with unmutated immunoglobulin receptors
<i>Tp53</i>gene p72R polymorphism in chronic lymphocytic leukemia: incidence and clinical significance amongst cases with unmutated immunoglobulin receptors Open
Chronic lymphocytic leukemia (CLL) displays extreme clinical heterogeneity likely reflecting the underlying biological heterogeneity. For this reason, intense research efforts have addressed progno...
View article: The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia
The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia Open
The histone methyltransferase EZH2 induces gene repression through trimethylation of histone H3 at lysine 27 (H3K27me3). EZH2 overexpression has been reported in many types of cancer and associated with poor prognosis. Here we investigated…
View article: Carnosic acid biosynthesis elucidated by a synthetic biology platform
Carnosic acid biosynthesis elucidated by a synthetic biology platform Open
Significance Here we report on the development of a modular terpene production platform as a screening tool for the functional characterization of next-generation sequencing information and on the application of this system in the characte…
View article: Towards Elucidating Carnosic Acid Biosynthesis in Lamiaceae: Functional Characterization of the Three First Steps of the Pathway in Salvia fruticosa and Rosmarinus officinalis
Towards Elucidating Carnosic Acid Biosynthesis in Lamiaceae: Functional Characterization of the Three First Steps of the Pathway in Salvia fruticosa and Rosmarinus officinalis Open
Carnosic acid (CA) is a phenolic diterpene with anti-tumour, anti-diabetic, antibacterial and neuroprotective properties that is produced by a number of species from several genera of the Lamiaceae family, including Salvia fruticosa (Creta…
View article: Iterative carotenogenic screens identify combinations of yeast gene deletions that enhance sclareol production
Iterative carotenogenic screens identify combinations of yeast gene deletions that enhance sclareol production Open
Using an iterative approach, we identified novel combinations of yeast gene deletions that improve carotenoid and sclareol production titers without compromising strain growth and viability. Most of the identified deletions have not previo…