Antonios N. Gargalionis
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View article: The Role of Angiogenetic Factors in Preeclampsia
The Role of Angiogenetic Factors in Preeclampsia Open
Preeclampsia (PE) occurs in approximately 2–8% of all pregnancies worldwide and represents one of the primary causes of maternal and fetal morbidity and mortality. Angiogenic growth factors such as placental growth factor (PlGF) and vascul…
View article: SUV39H1 regulates progression of pediatric diffuse high-grade gliomas through modulation of β-catenin/TCF4 levels
SUV39H1 regulates progression of pediatric diffuse high-grade gliomas through modulation of β-catenin/TCF4 levels Open
Pediatric diffuse high-grade gliomas (pHGGs) are heterogeneous and infiltrative tumors with poor prognosis. Recent molecular characterization of pHGGs has revealed an altered epigenetic profile with aberrant post-translational modification…
View article: LINE-1 hypomethylation in cell-free DNA of high-grade glioma patients correlates with tissue levels and is associated with reduced DNMT1 and H4K20me3 expression
LINE-1 hypomethylation in cell-free DNA of high-grade glioma patients correlates with tissue levels and is associated with reduced DNMT1 and H4K20me3 expression Open
Gliomas exhibit diverse genetic, molecular, and histological profiles with limited liquid biopsy biomarkers. Loss of Long Interspersed Nuclear Element-1 (LINE-1) methylation confers to genomic instability and tumorigenesis, primarily media…
View article: Nutrition-related biomarkers of metabolic disorders among immigrants in Athens, Greece: a cross- sectional study
Nutrition-related biomarkers of metabolic disorders among immigrants in Athens, Greece: a cross- sectional study Open
Further studies are required to investigate nutritional and lifestyle risk factors and provide effective preventive strategies for the nutrition-related metabolic disorders in immigrants.
View article: SUV39H1 regulates progression of pediatric diffuse high-grade gliomas through modulation of β-catenin/TCF4 levels
SUV39H1 regulates progression of pediatric diffuse high-grade gliomas through modulation of β-catenin/TCF4 levels Open
Background Pediatric high-grade gliomas (pHGGs) are heterogeneous, diffuse, and infiltrative tumors with dismal prognosis. Recent molecular characterization of pHGGs has revealed aberrant post-translational histone modifications with eleva…
View article: YAP/TAZ Signaling in the Pathobiology of Pulmonary Fibrosis
YAP/TAZ Signaling in the Pathobiology of Pulmonary Fibrosis Open
Pulmonary fibrosis (PF) is a severe, irreversible lung disease characterized by progressive scarring, with idiopathic pulmonary fibrosis (IPF) being the most prevalent form. IPF’s pathogenesis involves repetitive lung epithelial injury lea…
View article: Precision Targeting Strategies in Pancreatic Cancer: The Role of Tumor Microenvironment
Precision Targeting Strategies in Pancreatic Cancer: The Role of Tumor Microenvironment Open
Pancreatic cancer demonstrates an ever-increasing incidence over the last years and represents one of the top causes of cancer-associated mortality. Cells of the tumor microenvironment (TME) interact with cancer cells in pancreatic ductal …
View article: Biomarkers in Cerebrospinal Fluid for the Diagnosis and Monitoring of Gliomas
Biomarkers in Cerebrospinal Fluid for the Diagnosis and Monitoring of Gliomas Open
Gliomas are the most common type of malignant brain tumor and are characterized by a plethora of heterogeneous molecular alterations. Current treatments require the emergence of reliable biomarkers that will aid personalized treatment deci…
View article: Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer (NSCLC) Treatment: Quo Vadis?
Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer (NSCLC) Treatment: Quo Vadis? Open
Lung cancer has been established as the second most common cancer worldwide (most common cancer in men and second most common cancer in women) and as the leading cause of cancer morbidity among neoplasms [...]
View article: Runx2 and Polycystins in Bone Mechanotransduction: Challenges for Therapeutic Opportunities
Runx2 and Polycystins in Bone Mechanotransduction: Challenges for Therapeutic Opportunities Open
Bone mechanotransduction is a critical process during skeletal development in embryogenesis and organogenesis. At the same time, the type and level of mechanical loading regulates bone remodeling throughout the adult life. The aberrant mec…
View article: Mechanotransduction Circuits in Human Pathobiology
Mechanotransduction Circuits in Human Pathobiology Open
It is widely acknowledged that mechanical forces exerted throughout the human body are critical for cellular and tissue homeostasis [...]
View article: mTOR Signaling: Recent Progress
mTOR Signaling: Recent Progress Open
In the intricate landscape of human biology, the mechanistic target of rapamycin (mTOR) emerges as a key regulator, orchestrating a vast array of processes in health and disease [...]
View article: The potential of BRD4 inhibition in tumour mechanosignaling
The potential of BRD4 inhibition in tumour mechanosignaling Open
It is broadly acknowledged that physical properties of cancer cells play a crucial role in all aspects of tumour development, from cancer initiation to malignant progression. Aberrant mechanical forces shape a dynamic interplay between tum…
View article: Are <scp>YAP</scp> and <scp>TAZ</scp> valid prognostic signatures for <scp>NSCLC</scp> patients?
Are <span>YAP</span> and <span>TAZ</span> valid prognostic signatures for <span>NSCLC</span> patients? Open
It is well established that cancer cell biomechanics represents an important factor engaged in non-small cell lung cancer (NSCLC) development and progression. Mechanosensor proteins mediate an interplay between cancer cells, alterations of…
View article: Objective Physical Function in the Alzheimer’s Disease Continuum: Association with Cerebrospinal Fluid Biomarkers in the ALBION Study
Objective Physical Function in the Alzheimer’s Disease Continuum: Association with Cerebrospinal Fluid Biomarkers in the ALBION Study Open
Cognitive and physical decline, both indicators of aging, seem to be associated with each other. The aim of the present study was to investigate whether physical function parameters (walking time and handgrip strength) are related to cereb…
View article: Implication of mTOR Signaling in NSCLC: Mechanisms and Therapeutic Perspectives
Implication of mTOR Signaling in NSCLC: Mechanisms and Therapeutic Perspectives Open
Mechanistic target of the rapamycin (mTOR) signaling pathway represents a central cellular kinase that controls cell survival and metabolism. Increased mTOR activation, along with upregulation of respective upstream and downstream signalin…
View article: Exosomes as Novel Diagnostic Biomarkers and Therapeutic Tools in Gliomas
Exosomes as Novel Diagnostic Biomarkers and Therapeutic Tools in Gliomas Open
Exosomes constitute small extracellular vesicles that contain lipids, proteins, nucleic acids, and glycoconjugates from the secreted cells and are capable of transmitting signals between cells and coordinating cellular communication. By th…
View article: Targeting the YAP/TAZ mechanotransducers in solid tumour therapeutics
Targeting the YAP/TAZ mechanotransducers in solid tumour therapeutics Open
Extracellular matrix (ECM) interacts with solid tumour cells and cells from the tumour microenvironment (ΤΜΕ). Components of the ECM and various types of mechanical forces which are generated from ECM stiffening modulate properties of soli…
View article: Initial Data and a Clinical Diagnosis Transition for the Aiginition Longitudinal Biomarker Investigation of Neurodegeneration (ALBION) Study
Initial Data and a Clinical Diagnosis Transition for the Aiginition Longitudinal Biomarker Investigation of Neurodegeneration (ALBION) Study Open
Background and Objectives: This article presents data from the ongoing Aiginition Longitudinal Biomarker Investigation of Neurodegeneration study (ALBION) regarding baseline clinical characterizations and CSF biomarker profiles, as well as…
View article: New Insights into the Molecular Interplay between Human Herpesviruses and Alzheimer’s Disease—A Narrative Review
New Insights into the Molecular Interplay between Human Herpesviruses and Alzheimer’s Disease—A Narrative Review Open
Human herpesviruses (HHVs) have been implicated as possible risk factors in Alzheimer’s disease (AD) pathogenesis. Persistent lifelong HHVs infections may directly or indirectly contribute to the generation of AD hallmarks: amyloid beta (A…
View article: Sex Differences in Frailty Incidence in Greek Community-Dwelling Older People: The HELIAD Study
Sex Differences in Frailty Incidence in Greek Community-Dwelling Older People: The HELIAD Study Open
Differences between the two sexes indicate that when exploring the factors that are related to frailty, studies should provide data disaggregated for men and women.
View article: Polycystins, mechanotransduction and cancer development
Polycystins, mechanotransduction and cancer development Open
Solid tumours represent the most frequent type of tumours worldwide, and they are responsible for high morbidity and mortality rates.1 There is an ongoing and compelling need for novel prognostic, diagnostic and predictive markers to tailo…
View article: Polycystin‐1 regulates cell proliferation and migration through AKT/mTORC2 pathway in a human craniosynostosis cell model
Polycystin‐1 regulates cell proliferation and migration through AKT/mTORC2 pathway in a human craniosynostosis cell model Open
Craniosynostosis is the premature fusion of skull sutures and has a severe pathological impact on childrens’ life. Mechanical forces are capable of triggering biological responses in bone cells and regulate osteoblastogenesis in cranial su…