Antony Ambler
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View article: Quantifying the impact of early life growth adversity on later life health
Quantifying the impact of early life growth adversity on later life health Open
Background Early-life growth adversity is important to later-life health, but precision assessment in adulthood is challenging. We evaluated whether the difference between attained and genotype-predicted adult height (“height-GaP”) would a…
View article: Maternal expressions of warmth and negativity and adolescent mental health: using longitudinal monozygotic twin‐difference analyses to approach causal inference
Maternal expressions of warmth and negativity and adolescent mental health: using longitudinal monozygotic twin‐difference analyses to approach causal inference Open
Background Emotions that mothers express about their offspring are associated with offspring mental health during childhood, but little research has explored whether this extends into adolescence. We investigated associations between mater…
View article: Quantifying the impact of early-life growth adversity on later-life health
Quantifying the impact of early-life growth adversity on later-life health Open
Background Early-life growth adversity is important to later-life health, but precision assessment in adulthood is challenging. We evaluated whether the difference between attained and genotype-predicted adult height (“height-GaP”) would a…
View article: Examining the relationship between plasma pTau181 and cognitive decline, structural brain integrity, and biological ageing in midlife
Examining the relationship between plasma pTau181 and cognitive decline, structural brain integrity, and biological ageing in midlife Open
INTRODUCTION Although plasma pTau181 has been shown to accurately discriminate patients with Alzheimer’s disease from healthy older adults, its utility as a preclinical biomarker in middle-aged community-based cohorts is unclear. METHODS P…
View article: Trajectories of Hearing From Childhood to Adulthood
Trajectories of Hearing From Childhood to Adulthood Open
Objectives: The Dunedin Multidisciplinary Health and Development Study provides a unique opportunity to document the progression of ear health and hearing ability within the same cohort of individuals from birth. This investigation draws o…
View article: Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood
Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood Open
View article: Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis
Association between relative age at school and persistence of ADHD in prospective studies: an individual participant data meta-analysis Open
View article: Tracing the origins of midlife despair: association of psychopathology during adolescence with a syndrome of despair-related maladies at midlife
Tracing the origins of midlife despair: association of psychopathology during adolescence with a syndrome of despair-related maladies at midlife Open
Background Midlife adults are experiencing a crisis of deaths of despair (i.e. deaths from suicide, drug overdose, and alcohol-related liver disease). We tested the hypothesis that a syndrome of despair-related maladies at midlife is prece…
View article: Socioenvironmental Adversity and Adolescent Psychotic Experiences: Exploring Potential Mechanisms in a UK Longitudinal Cohort
Socioenvironmental Adversity and Adolescent Psychotic Experiences: Exploring Potential Mechanisms in a UK Longitudinal Cohort Open
Background and Hypothesis Children exposed to socioenvironmental adversities (eg, urbanicity, pollution, neighborhood deprivation, crime, and family disadvantage) are more likely to subsequently develop subclinical psychotic experiences du…
View article: Childhood Social Isolation as a Predictor of Retinal Neuronal Thickness in Middle Age: A Lifecourse Birth Cohort Study
Childhood Social Isolation as a Predictor of Retinal Neuronal Thickness in Middle Age: A Lifecourse Birth Cohort Study Open
Objective We investigated whether childhood social isolation was associated with retinal neural layer changes in adulthood, and whether this association was independent of other childhood or adulthood risk factors, including adult social i…
View article: Childhood sexual abuse and pervasive problems across multiple life domains: Findings from a five-decade study
Childhood sexual abuse and pervasive problems across multiple life domains: Findings from a five-decade study Open
The aim of this study was to use longitudinal population-based data to examine the associations between childhood sexual abuse (CSA) and risk for adverse outcomes in multiple life domains across adulthood. In 937 individuals followed from …
View article: Preparedness for healthy ageing and polysubstance use in long-term cannabis users: a population-representative longitudinal study
Preparedness for healthy ageing and polysubstance use in long-term cannabis users: a population-representative longitudinal study Open
View article: Improving risk indexes for Alzheimer’s disease and related dementias for use in midlife
Improving risk indexes for Alzheimer’s disease and related dementias for use in midlife Open
Knowledge of a person’s risk for Alzheimer’s disease and related dementias (ADRDs) is required to triage candidates for preventive interventions, surveillance, and treatment trials. ADRD risk indexes exist for this purpose, but each includ…
View article: Diminished Structural Brain Integrity in Long-term Cannabis Users Reflects a History of Polysubstance Use
Diminished Structural Brain Integrity in Long-term Cannabis Users Reflects a History of Polysubstance Use Open
View article: Deep-seated psychological histories of COVID-19 vaccine hesitance and resistance
Deep-seated psychological histories of COVID-19 vaccine hesitance and resistance Open
To design effective provaccination messaging, it is important to know “where people are coming from”—the personal experiences and long-standing values, motives, lifestyles, preferences, emotional tendencies, and information-processing capa…
View article: Long-Term Cannabis Use and Cognitive Reserves and Hippocampal Volume in Midlife
Long-Term Cannabis Use and Cognitive Reserves and Hippocampal Volume in Midlife Open
Long-term cannabis users showed cognitive deficits and smaller hippocampal volume in midlife. Research is needed to ascertain whether long-term cannabis users show elevated rates of dementia in later life.
View article: Association of Treatable Health Conditions During Adolescence With Accelerated Aging at Midlife
Association of Treatable Health Conditions During Adolescence With Accelerated Aging at Midlife Open
This study found that adolescent smoking, obesity, and psychological disorder diagnoses were associated with older biological age at midlife. These health conditions could be treated during adolescence to reduce the risk of accelerated bio…
View article: Associations Between Retinal Nerve Fiber Layer and Ganglion Cell Layer in Middle Age and Cognition From Childhood to Adulthood
Associations Between Retinal Nerve Fiber Layer and Ganglion Cell Layer in Middle Age and Cognition From Childhood to Adulthood Open
RNFL and GCL thickness in middle age was associated with cognitive performance in childhood and adulthood, and thinner RNFL with a decline in processing speed between childhood and adulthood. These data emphasize the potential utility of O…
View article: Early life air pollution exposure elevates general psychopathology risk at the transition to adulthood
Early life air pollution exposure elevates general psychopathology risk at the transition to adulthood Open
BACKGROUND AND AIM: Air pollution exposure has been shown to damage the brain but its associations with the development of psychopathology are not fully characterized. This study tested whether early life air pollution exposure is associat…
View article: Psychopathology and cognitive deficits in young people exposed to complex trauma
Psychopathology and cognitive deficits in young people exposed to complex trauma Open
Aims Complex traumas are traumatic experiences that involve multiple interpersonal threats during childhood or adolescence, such as repeated abuse. This type of trauma is hypothesized to lead to more severe psychopathology and poorer cogni…
View article: Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45
Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 Open
Growing evidence indicates that the defining characteristics of autism spectrum disorder (ASD) are distributed throughout the general population; hence, understanding the correlates of aging in people with high autistic traits could shed l…
View article: Unravelling the contribution of complex trauma to psychopathology and cognitive deficits: a cohort study
Unravelling the contribution of complex trauma to psychopathology and cognitive deficits: a cohort study Open
Background Complex traumas are traumatic experiences that involve multiple interpersonal threats during childhood or adolescence, such as repeated abuse. These traumas are hypothesised to cause more severe psychopathology and poorer cognit…
View article: Association of Air Pollution Exposure in Childhood and Adolescence With Psychopathology at the Transition to Adulthood
Association of Air Pollution Exposure in Childhood and Adolescence With Psychopathology at the Transition to Adulthood Open
Youths exposed to higher levels of outdoor NOx experienced greater psychopathology at the transition to adulthood. Air pollution may be a nonspecific risk factor for the development of psychopathology.
View article: Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy Open
View article: Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy Open
All humans age, but some age faster than others. Variation in biological aging can be measured in midlife, but the implications of this variation are poorly understood. We tested associations between biological aging and indicators of futu…
View article: Long-term Neural Embedding of Childhood Adversity in a Population-Representative Birth Cohort Followed for 5 Decades
Long-term Neural Embedding of Childhood Adversity in a Population-Representative Birth Cohort Followed for 5 Decades Open
View article: Association of History of Psychopathology With Accelerated Aging at Midlife
Association of History of Psychopathology With Accelerated Aging at Midlife Open
In this cohort study, a history of psychopathology was associated with accelerated aging at midlife, years before the typical onset of age-related diseases. This link is not specific to any particular disorder family but generalizes across…
View article: Population vs Individual Prediction of Poor Health From Results of Adverse Childhood Experiences Screening
Population vs Individual Prediction of Poor Health From Results of Adverse Childhood Experiences Screening Open
This study suggests that, although ACE scores can forecast mean group differences in health, they have poor accuracy in predicting an individual's risk of later health problems. Therefore, targeting interventions based on ACE screening is …
View article: Childhood self-control forecasts the pace of midlife aging and preparedness for old age
Childhood self-control forecasts the pace of midlife aging and preparedness for old age Open
Significance We followed a population-representative cohort of children from birth to their mid-forties. As adults, children with better self-control aged more slowly in their bodies; showed fewer signs of brain aging; and were more equipp…
View article: Association Between Elevated suPAR, a New Biomarker of Inflammation, and Accelerated Aging
Association Between Elevated suPAR, a New Biomarker of Inflammation, and Accelerated Aging Open
Background To understand and measure the association between chronic inflammation, aging, and age-related diseases, broadly applicable standard biomarkers of systemic chronic inflammation are needed. We tested whether elevated blood levels…