Explanipedia

Evaluating the metabolic effects of neoadjuvant treatment in clear cell renal cell carcinoma using hyperpolarized [1-13 C]pyruvate MRI Open

Ines Horvat‐Menih, Mary A. McLean, Jonathan R. Birchall, Maria Jesus Zamora Morales, Marta Wylot , et al. · 2025

Despite recent therapeutic advances, renal cell carcinoma (RCC) has a high mortality rate. The development of new neoadjuvant strategies requires reliable companion biomarkers of early and successful response to treatment. A change in tumo…

Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma Open

Cissy Yong, Christina Schmidt, Ming Yang, Alex von Kriegsheim, Anne Y. Warren , et al. · 2025

Human isotopic tracer studies are key for in vivo studies of cancer metabolism. Yet, the effects of sampling conditions on the tissue metabolome remain understudied. Here, we perform a 13 C-glucose study coupled with metabolomic, transcrip…

Cambridge kidney One-Stop Mass Investigation Clinic (CkOSMIC): A Nonrandomised Feasibility Study Open

Chiara Re, James P. Blackmur, Teele Kuusk, Thomas J. Mitchell, James N. Armitage , et al. · 2025

CkOSMIC was feasible and showed high sensitivity and specificity in diagnosing cancer, while being safe and acceptable. It allows cancer targets to be met, reduces hospital visits and potentially reduces anxiety of delays in forming a trea…

Evaluating the metabolic effects of neoadjuvant treatment in clear cell renal cell carcinoma using hyperpolarised [1-<sup>13</sup>C]pyruvate MRI Open

Ines Horvat‐Menih, Mary A. McLean, Jonathan R. Birchall, Maria Jesus Zamora Morales, Marta Wylot , et al. · 2025

Despite recent advances, ∼50% of people developing renal cell carcinoma (RCC) will die of the disease. The development of new neoadjuvant therapeutic strategies requires reliable companion biomarkers to measure early and successful respons…

Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma Open

Christian Frezza, Cissy Yong, Christina Schmidt, Ming Yang, Alex von Kriegsheim , et al. · 2024

Human isotopic tracer studies are fast becoming the gold standard model to study cancer metabolism in vivo . Analysed tissues are typically retrieved after surgical resection, which exposes them to a variable extent of warm ischaemia. Alth…

PE078 Robotic assisted retroperitoneal lymph node dissection: Defining selection parameters: A B-SAFE approach from the Anglican germ cell cancer collaborative group Open

Khwaja F. Haq, David Chia, Usman Haroon, A. Oluwole-Ojo, Fairleigh Reeves , et al. · 2024

‘Case of the Month’ from Addenbrooke's Hospital, Cambridge, <span>UK</span> : surgery after near complete response to combined immunotherapy and tyrosine kinase inhibitor therapy for metastatic renal cell carcinoma with inferior vena cava tumour thrombus Open

James P. Blackmur, James N. Armitage, James O. Jones, Antony C. P. Riddick, Thomas J. Mitchell , et al. · 2024

While systemic anti-cancer therapy (SACT) has become the principal management option for many patients with metastatic RCC, there remains debate on the benefits of delayed cytoreductive nephrectomy (CN), and on whether immediate CN and tum…

High-resolution and highly accelerated MRI T2 mapping as a tool to characterise renal tumour subtypes and grades Open

Ines Horvat‐Menih, Hao Li, Andrew N. Priest, Shaohang Li, Andrew B. Gill , et al. · 2024

Table of Contents Open

Priyank Yadav, Abdulrahman Alsabban, Thomas De, Los Reyes, Abby Varghese , et al. · 2023

Supplementary Figures 1-2, Supplementary Tables 1-2 from Sunitinib Treatment Exacerbates Intratumoral Heterogeneity in Metastatic Renal Cancer Open

Grant D. Stewart, Fiach C. O’Mahony, Alexander Laird, Lél Eöry, Alexander L. R. Lubbock , et al. · 2023

Supplementary Figures 1-2, Supplementary Tables 1-2. Fig. S1. Histogram showing lack of correlation between differential protein and RNA expression levels between sunitinib naive and treated patient samples; Figure S2: Dendrograms illustra…

Supplementary Figures 1-2, Supplementary Tables 1-2 from Sunitinib Treatment Exacerbates Intratumoral Heterogeneity in Metastatic Renal Cancer Open

Grant D. Stewart, Fiach C. O’Mahony, Alexander Laird, Lél Eöry, Alexander L. R. Lubbock , et al. · 2023

Supplementary Figures 1-2, Supplementary Tables 1-2. Fig. S1. Histogram showing lack of correlation between differential protein and RNA expression levels between sunitinib naive and treated patient samples; Figure S2: Dendrograms illustra…

Data from Sunitinib Treatment Exacerbates Intratumoral Heterogeneity in Metastatic Renal Cancer Open

Grant D. Stewart, Fiach C. O’Mahony, Alexander Laird, Lél Eöry, Alexander L. R. Lubbock , et al. · 2023

Purpose: The aim of this study was to investigate the effect of VEGF-targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC).Experimental Design: Multiple tumo…

Data from Sunitinib Treatment Exacerbates Intratumoral Heterogeneity in Metastatic Renal Cancer Open

Grant D. Stewart, Fiach C. O’Mahony, Alexander Laird, Lél Eöry, Alexander L. R. Lubbock , et al. · 2023

Purpose: The aim of this study was to investigate the effect of VEGF-targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC).Experimental Design: Multiple tumo…

Assessment of association between lower ureteric excision technique and oncological outcomes for upper urinary tract urothelial carcinoma: retrospective analysis from the Scottish Renal Cancer Consortium Open

James P. Blackmur, Etienne Chew, Matthew Trail, Katie Brodie, N Santoni , et al. · 2023

Tyrosine kinase inhibitor treatment for renal cell carcinoma with inferior vena cava tumour thrombus: a quantitative summary Open

Tobias Klatte, Sarah J. Welsh, Antony C. P. Riddick, José A. Karam, Grant D. Stewart · 2023

Renal cell carcinoma (RCC) with venous tumour thrombus (VTT) extension into the inferior vena cava (IVC) occurs in about 4%–15% of cases [1]. Surgical complexity, as well as perioperative complications and morbidity, are significant (5%–15…

Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer Open

Ruoyan Li, John R. Ferdinand, Kevin W. Loudon, Georgina Bowyer, Sean Laidlaw , et al. · 2022

A Phase II study of neoadjuvant axitinib for reducing the extent of venous tumour thrombus in clear cell renal cell cancer with venous invasion (NAXIVA) Open

Grant D. Stewart, Sarah J. Welsh, Stephan Ursprung, Ferdia A. Gallagher, James O. Jones , et al. · 2022

Hyperpolarized 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma—A Proof of Principle Study Open

Stephan Ursprung, Ramona Woitek, Mary A. McLean, Andrew N. Priest, Mireia Crispin‐Ortuzar , et al. · 2022

Differentiating aggressive clear cell renal cell carcinoma (ccRCC) from indolent lesions is challenging using conventional imaging. This work prospectively compared the metabolic imaging phenotype of renal tumors using carbon-13 MRI follow…

Multi-regional characterisation of renal cell carcinoma and microenvironment at single cell resolution Open

Ruoyan Li, John R. Ferdinand, Kevin W. Loudon, Georgina Bowyer, Lira Mamanova , et al. · 2021

Tumour behaviour is dependent on the oncogenic properties of cancer cells and their multi-cellular interactions. These dependencies were examined through 270,000 single cell transcriptomes and 100 micro-dissected whole exomes obtained from…

Dynamic biomarker and imaging changes from a phase II study of pre‐ and post‐surgical sunitinib Open

Sarah J. Welsh, Nicola Thompson, Anne Y. Warren, Andrew N. Priest, Tristan Barrett , et al. · 2021

Objective To explore translational biological and imaging biomarkers for sunitinib treatment before and after debulking nephrectomy in the NeoSun (European Union Drug Regulating Authorities Clinical Trials Database [EudraCT] number: 2005‐0…

The Efficacy of Sunitinib Treatment of Renal Cancer Cells Is Associated with the Protein PHAX In Vitro Open

Rafia S. Al‐Lamki, Nicholas J. Hudson, John R. Bradley, Anne Y. Warren, Tim Eisen , et al. · 2020

Anti-angiogenic agents, such as the multi-tyrosine kinase inhibitor sunitinib, are key first line therapies for metastatic clear cell renal cell carcinoma (ccRCC), but their mechanism of action is not fully understood. Here, we take steps …

Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors Open

Christopher G. Smith, Tina Moser, Florent Moulière, Johanna Field-Rayner, Matthew Eldridge , et al. · 2020

Additional file 3 of Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors Open

Christopher G. Smith, Tina Moser, Florent Moulière, Johanna Field-Rayner, Matthew Eldridge , et al. · 2020

Table S8. Summary of all mutation data of the MonReC cohort.

Additional file 2 of Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors Open

Christopher G. Smith, Tina Moser, Florent Moulière, Johanna Field-Rayner, Matthew Eldridge , et al. · 2020

Bed file showing all genomic regions targeted by INVAR-TAPAS of DIAMOND patients.

The VENUSS prognostic model to predict disease recurrence following surgery for non-metastatic papillary renal cell carcinoma: development and evaluation using the ASSURE prospective clinical trial cohort Open

Tobias Klatte, Kevin Gallagher, Luca Afferi, Alessandro Volpe, Nils Kroeger , et al. · 2019

Spatiotemporal immune zonation of the human kidney Open

Benjamin J. Stewart, John R. Ferdinand, Matthew D. Young, Thomas J. Mitchell, Kevin W. Loudon , et al. · 2019

Immune landscape of the human kidney Single-cell RNA sequencing has begun to shed light on the full cellular diversity of specific organs. However, these studies rarely examine organ-specific immune cells. Stewart et al. sequenced healthy …

Comprehensive characterisation of cell-free tumour DNA in plasma and urine of patients with renal tumours Open

Christopher G. Smith, Tina Moser, Johanna Burge, Matthew Eldridge, Anja Lisa Riediger , et al. · 2019

Cell-free tumour-derived DNA (ctDNA) allows non-invasive monitoring of cancers but its utility in renal cell cancer (RCC) has not been established. Here, untargeted and targeted sequencing methods, applied to two independent cohorts of ren…

Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors Open

Matthew D. Young, Thomas J. Mitchell, Felipe A. Vieira Braga, Maxine Tran, Benjamin J. Stewart , et al. · 2018

Pediatric and adult kidney tumors differ Understanding tumor origins and the similarities and differences between organ-specific cancers is important for determining treatment options. Young et al. generated more than 72,000 single-cell tr…

Prognostic effect of cytoreductive nephrectomy in synchronous metastatic renal cell carcinoma: a comparative study using inverse probability of treatment weighting Open

Tobias Klatte, Kate Fife, Sarah J. Welsh, Manavi Sachdeva, James N. Armitage , et al. · 2017

Different Successful Management Strategies for Obstructing Renal Parapelvic Cysts Open

Sabrina H. Rossi, Brendan Koo, Antony C. P. Riddick, Nimish Shah, Grant D. Stewart · 2017

Parapelvic cysts originate in the renal parenchyma and extend into the renal sinus. A series of 3 patients with symptomatic obstructing parapelvic cysts is described, 2 with acute presentations, and 1 with chronic symptoms. In 2 of the 3 c…

Antony C. P. Riddick YOU? Author Swipe