Antony D. Gee
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View article: Pyridine-based Strategy towards Nitrogen Isotope Exchange
Pyridine-based Strategy towards Nitrogen Isotope Exchange Open
Isotopic labeling is at the core of health and life science applications such as nuclear imaging, pharmacokinetics and bio-distribution studies and plays a central role in drug development. The rapid access to isotopically labeled organic …
View article: Correction to “Radiosynthesis, Preclinical and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds”
Correction to “Radiosynthesis, Preclinical and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds” Open
ADVERTISEMENT RETURN TO ARTICLES ASAPAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Radiosynthesis, Preclinical and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural…
View article: Correction to “A Medicinal Chemistry Perspective on Excitatory Amino Acid Transporter 2 Dysfunction in Neurodegenerative Diseases”
Correction to “A Medicinal Chemistry Perspective on Excitatory Amino Acid Transporter 2 Dysfunction in Neurodegenerative Diseases” Open
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "A Medicinal Chemistry Perspective on Excitatory Amino Acid Transporter 2 Dysfunction in Neurodegenerative Diseases"Igor C. Fo…
View article: A Medicinal Chemistry Perspective on Excitatory Amino Acid Transporter 2 Dysfunction in Neurodegenerative Diseases
A Medicinal Chemistry Perspective on Excitatory Amino Acid Transporter 2 Dysfunction in Neurodegenerative Diseases Open
The excitatory amino acid transporter 2 (EAAT2) plays a key role in the clearance and recycling of glutamate - the major excitatory neurotransmitter in the mammalian brain. EAAT2 loss/dysfunction triggers a cascade of neurodegenerative eve…
View article: Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds
Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds Open
The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the PET trace…
View article: Recounting a Dream about Music, Language and Submitting an Abstract for Voices
Recounting a Dream about Music, Language and Submitting an Abstract for Voices Open
Hi Mike .... I had the idea yesterday to submit some of my music pieces as part of an abstract submission to "Voices: A World Forum for Music Therapy to explore the topic of language and power in music therapy. " posted yesterday. These ar…
View article: Rapid ‘on-column’ preparation of hydrogen [<sup>11</sup>C]cyanide from [<sup>11</sup>C]methyl iodide <i>via</i> [<sup>11</sup>C]formaldehyde
Rapid ‘on-column’ preparation of hydrogen [<sup>11</sup>C]cyanide from [<sup>11</sup>C]methyl iodide <i>via</i> [<sup>11</sup>C]formaldehyde Open
In a reaction column, gaseous [ 11 C]methyl iodide was converted to [ 11 C]formaldehyde in a first layer containing N -oxide and then transformed into hydrogen [ 11 C]cyanide in a second layer containing hydroxylamine- O -sulfonic acid wit…
View article: Production of copper-64 using a hospital cyclotron: targetry, purification and quality analysis
Production of copper-64 using a hospital cyclotron: targetry, purification and quality analysis Open
Objectives To construct and evaluate a 64 Cu production system that minimises the amount of costly 64 Ni, radionuclidic impurities and nonradioactive metal contamination and maximises radiochemical and radionuclidic purity and molar activi…
View article: Carbon‐11 carboxylation of terminal alkynes with [<sup>11</sup>C]CO<sub>2</sub>
Carbon‐11 carboxylation of terminal alkynes with [<sup>11</sup>C]CO<sub>2</sub> Open
A copper‐catalysed radiosynthesis of carbon‐11 radiolabelled carboxylic acids was developed by reacting terminal alkynes and cyclotron‐produced carbon‐11 carbon dioxide ([ 11 C]CO 2 ) in the presence of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (…
View article: Silicon compounds in carbon-11 radiochemistry: present use and future perspectives
Silicon compounds in carbon-11 radiochemistry: present use and future perspectives Open
The use of silicon-based reagents and precursors for carbon-11 labelling has shown wide applicability and robustness with short reaction times using mild conditions. In this review, recent advances and future perspectives are examined.
View article: The Hantzsch reaction for nitrogen-13 PET: preparation of [<sup>13</sup>N]nifedipine and derivatives
The Hantzsch reaction for nitrogen-13 PET: preparation of [<sup>13</sup>N]nifedipine and derivatives Open
The Hantzsch reaction was adapted to allow the rapid radiosynthesis of 13N-labelled 1,4-dihydropyridines, including [13N]nifedipine, for preclinical PET imaging.
View article: Evaluation of [13N]ammonia positron emission tomography as a potential method for quantifying glutamine synthetase activity in the human brain.
Evaluation of [13N]ammonia positron emission tomography as a potential method for quantifying glutamine synthetase activity in the human brain. Open
Purpose: The conversion of synaptic glutamate to glutamine in astrocytes by glutamine synthetase (GS) is critical to maintaining healthy brain activity and may be disrupted in several brain disorders. As the GS catalysed conversion of glut…
View article: Imaging Biotin Trafficking In Vivo with Positron Emission Tomography
Imaging Biotin Trafficking In Vivo with Positron Emission Tomography Open
The water-soluble vitamin biotin is essential for cellular growth, development, and well-being, but its absorption, distribution, metabolism, and excretion are poorly understood. This paper describes the radiolabeling of biotin with the po…
View article: Imaging niacin trafficking with positron emission tomography reveals in vivo monocarboxylate transporter distribution
Imaging niacin trafficking with positron emission tomography reveals in vivo monocarboxylate transporter distribution Open
Here, we describe the efficient preparation of [11C]niacin as PET imaging agent for probing the trafficking of nutrient demand in healthy rodents by intravenous and oral administration, providing a translatable technique to enable the futu…
View article: Evaluation of [13N]ammonia Positron Emission Tomography for Quantifying Glutamine Synthetase Activity in the Human Brain.
Evaluation of [13N]ammonia Positron Emission Tomography for Quantifying Glutamine Synthetase Activity in the Human Brain. Open
Purpose The conversion of synaptic glutamate to glutamine in astrocytes by glutamine synthetase (GS) is critical to maintaining healthy brain activity and may be disrupted in several brain disorders. As the GS catalysed conversion of gluta…
View article: Radiolabeling of [ <sup>11</sup> C]FPS-ZM1, a Receptor for Advanced Glycation End products-targeting Positron Emission Tomography radiotracer, Using a [ <sup>11</sup> C]CO <sub>2</sub> -to-[ <sup>11</sup> C]CO Chemical Conversion
Radiolabeling of [ <sup>11</sup> C]FPS-ZM1, a Receptor for Advanced Glycation End products-targeting Positron Emission Tomography radiotracer, Using a [ <sup>11</sup> C]CO <sub>2</sub> -to-[ <sup>11</sup> C]CO Chemical Conversion Open
Aim: The receptor for advanced glycation end products (RAGE) is a viable target for early Alzheimer's disease (AD) diagnosis using positron emission tomography (PET) as RAGE overexpression precedes Aβ plaque formation. The development of a…
View article: Guidelines for the content and format of PET brain data in publications and archives: A consensus paper
Guidelines for the content and format of PET brain data in publications and archives: A consensus paper Open
It is a growing concern that outcomes of neuroimaging studies often cannot be replicated. To counteract this, the magnetic resonance (MR) neuroimaging community has promoted acquisition standards and created data sharing platforms, based o…
View article: Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [ <sup>11</sup> C]CO <sub>2</sub>
Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [ <sup>11</sup> C]CO <sub>2</sub> Open
A simple and rapid carbon-11 carboxylation radiosynthesis method.
View article: Radionuclide Imaging for Neuroscience: Current Opinion and Future Directions
Radionuclide Imaging for Neuroscience: Current Opinion and Future Directions Open
This meeting report summarizes a Consultants Meeting that was held at International Atomic Energy Agency headquarters in Vienna to provide an update on radionuclide imaging for neuroscience applications.
View article: Carbon-11 Carboxylation of Trialkoxysilane and Trimethylsilane Derivatives Using [¹¹C]CO2
Carbon-11 Carboxylation of Trialkoxysilane and Trimethylsilane Derivatives Using [¹¹C]CO2 Open
A novel carbon-11 carboxylation radiosynthesis methodology is described with the potential to be used to produce in vivo molecular imaging radiotracers for positron emission tomography. This is a simple and rapid method for incorporating c…
View article: Carbon-11 Carboxylation of Trialkoxysilane and Trimethylsilane Derivatives Using [¹¹C]CO2
Carbon-11 Carboxylation of Trialkoxysilane and Trimethylsilane Derivatives Using [¹¹C]CO2 Open
A novel carbon-11 carboxylation radiosynthesis methodology is described with the potential to be used to produce in vivo molecular imaging radiotracers for positron emission tomography. This is a simple and rapid method for incorporating c…
View article: CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice Open
Microglia have been implicated in amyloid beta-induced neuropathology, but their role in tau-induced neurodegeneration remains unclear. Mancuso et al. report that blockade of microglial proliferation by CSF1R inhibitor JNJ-40346527 modifie…