Explanipedia

Antimicrobial resistance trends of Escherichia coli and Staphylococcus aureus isolated from clinical blood cultures in Namibia: a nine-year (2011-2019) retrospective study Open

Erastus Haindongo, Antti Hakanen, Olli Vainio, Jaana Vuopio, Marius Hedimbi · 2025

Impact of Preeclampsia Duration on Long-Term Cardiovascular Disease Risk Open

Nina Keitaanpää, Jaakko Tyrmi, Elli Toivonen, Anni Kivelä, Tiina Jääskeläinen , et al. · 2025

BACKGROUND: Preeclampsia is associated with increased risk of subsequent maternal cardiovascular diseases (CVD) compared with normotensive pregnancies. We examined whether prolonging the duration between preeclampsia diagnosis and delivery…

Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty Open

Jonathan K. L. Mak, Chenxi Qin, M J T Krüger, Anna Kuukka, Aarno Palotie , et al. · 2025

Frailty is a clinically relevant phenotype with notable gaps in our understanding of its etiology. Using the Hospital Frailty Risk Score (HFRS) to define frailty, we performed a genome-wide association study in FinnGen ( N = 500,737), repl…

Viral acute respiratory illnesses in elite athletes: A 12-month controlled follow-up study Open

Raakel Luoto, Vesa Laatikainen‐Raussi, Katja Mjøsund, Maarit Valtonen, M Uhari , et al. · 2025

Background Viral acute respiratory illnesses (ARIs) are the most common acute illnesses in elite athletes. However, the occurrence, aetiology, and clinical manifestations of viral ARIs in athletes remain unclear. Methods Twenty-four elite …

Nalidixic acid—a good marker of fluoroquinolone resistance mechanisms in <i>Escherichia coli</i> Open

Sofia Kalinen, Heini Kallio, Teemu Kallonen, Juha Knaapila, Tarja Lamminen , et al. · 2025

The purpose of this study was to evaluate how ciprofloxacin, pefloxacin, and nalidixic acid disks perform in screening fluoroquinolone resistance mechanisms in 278 Escherichia coli isolates collected from a prospective clinical material. A…

ESBL plasmid compatibility with the surrounding microbial community influences ESBL gene survival under CRISPR-antimicrobial targeting Open

Cindy Given, Ilmur Jonsdottir, Krista Norvasuo, Petra Paananen, Pilvi Ruotsalainen , et al. · 2025

Bacteria often acquire resistance against antibiotics through the transfer of conjugative resistance plasmids. Hence, it is vital to develop strategies to mitigate the dispersal of antimicrobial resistance (AMR). CRISPR-based antimicrobial…

Longitudinal dynamics of gut plasmidome and antibiotic resistance during antibiotic therapy: a case report Open

Ilmur Jonsdottir, Sean Meaden, Paulina Salminen, Teemu Kallonen, Janne Ravantti , et al. · 2025

The human gut microbiome is composed of diverse microbes, and its association with human health is well-recognized. Antibiotic therapies for treating infectious diseases often mediate adverse influences on gut microbial ecosystems. Further…

Narcolepsy as a potential risk factor for Schizophrenia Open

Reyhane Eghtedarian, Anniina Tervi, Samuel E. Jones, Aarno Palotie, Mark Daly , et al. · 2025

Narcolepsy is a severe sleep disorder with characteristics of fatigue, fragmented sleep, cataplexy and hypnagogic hallucinations. Earlier clinical studies have reported the onset of schizophrenia after narcolepsy but the causality behind n…

Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations Open

Ville Salo, Juhani Määttä, Eeva Sliz, Aarno Palotie, Mark Daly , et al. · 2024

Given that lumbar disc herniation (LDH) is a prevalent spinal condition that causes significant individual suffering and societal costs, the genetic basis of LDH has received relatively little research. Our aim is to increase understanding…

Genetic Susceptibility to Acute Viral Bronchiolitis Open

Anu Pasanen, Minna K. Karjalainen, Matti Korppi, Mikko Hallman, Mika Rämet , et al. · 2024

Background Acute viral bronchiolitis is a major cause of infant hospitalizations worldwide. Childhood bronchiolitis is considered a risk factor for asthma, suggesting shared genetic factors and biological pathways. Genetic risk loci may pr…

Appendicolith classification: physical and chemical properties of appendicoliths in patients with CT diagnosed acute appendicitis – a prospective cohort study Open

Sanja Vanhatalo, Ermei Mäkilä, Antti Hakanen, Eveliina Munukka, Jarno Salonen , et al. · 2024

Objective Appendicoliths are associated with a more complicated course of acute appendicitis and failure of non-operative treatment. We aimed to update the appendicolith classification originally described in 1966 and to assess the associa…

Impact of the COVID-19 pandemic on extended-spectrum β-lactamase producing Escherichia coli in urinary tract and blood stream infections: results from a nationwide surveillance network, Finland, 2018 to 2022 Open

Heikki Ilmavirta, Jukka Ollgren, Kati Räisänen, Tuure Kinnunen, Antti Hakanen , et al. · 2024

Background Before the COVID-19 pandemic there has been a constant increase in antimicrobial resistance (AMR) of Escherichia coli , the most common cause of urinary tract infections and bloodstream infections. The aim of this study was to i…

High-throughput DNA extraction strategy for fecal microbiome studies Open

Heidi Isokääntä, Natalie Tomnikov, Sanja Vanhatalo, Eveliina Munukka, Pentti Huovinen , et al. · 2024

Microbiome studies are becoming larger in size to detect the potentially small effect that environmental factors have on our gut microbiomes, or that the microbiome has on our health. Therefore, fast and reproducible DNA isolation methods …

Differences in Gut Microbiota Profiles and Microbiota Steroid Hormone Biosynthesis in Men with and Without Prostate Cancer Open

Sofia Kalinen, Teemu Kallonen, Marianne Gunell, Otto Ettala, Ivan Jambor , et al. · 2024

Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women Open

Nina Mars, Sini Kerminen, Max Tamlander, Matti Pirinen, Eveliina Jakkula , et al. · 2024

PURPOSE Family history (FH) and pathogenic variants (PVs) are used for guiding risk surveillance in selected high-risk women but little is known about their impact for breast cancer screening on population level. In addition, polygenic ris…

High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases Open

Omar Youssef, Anu Loukola, Yossra H.S. Zidi-Mouaffak, Max Tamlander, Sanni Ruotsalainen , et al. · 2024

Formalin-fixed paraffin-embedded (FFPE) tissues stored in biobanks and pathology archives are a vast but underutilized source for molecular studies on different diseases. Beyond being the "gold standard" for preservation of diagnostic huma…

NTHL1 is a recessive cancer susceptibility gene Open

Anna Nurmi, Liisa M. Pelttari, Johanna I. Kiiski, Sofia Khan, Mika Nurmikolu , et al. · 2023

In search of novel breast cancer (BC) risk variants, we performed a whole-exome sequencing and variant analysis of 69 Finnish BC patients as well as analysed loss-of-function variants identified in DNA repair genes in the Finns from the Ge…

Increasing proportions of extended-spectrum β-lactamase-producing isolates among Escherichia coli from urine and bloodstream infections: results from a nationwide surveillance network, Finland, 2008 to 2019 Open

Heikki Ilmavirta, Jukka Ollgren, Kati Räisänen, Tuure Kinnunen, Antti Hakanen , et al. · 2023

Background Escherichia coli is the leading cause of urinary tract infections (UTI) and bloodstream infections (BSI), and the emergence of antimicrobial resistance (AMR) in E. coli causes concern. Aim To investigate changes in the proportio…

Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry) Open

Essi Viippola, Sara Kuitunen, Rodosthenis S. Rodosthenous, Andrius Vabalas, Tuomo Hartonen , et al. · 2023

The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections Open

Samuel E. Jones, Fahrisa I. Maisha, Satu Strausz, Vilma Lammi, Brian E. Cade , et al. · 2023

Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy Open

Jaakko Tyrmi, Tea Kaartokallio, A. Inkeri Lokki, Tiina Jääskeläinen, Eija Kortelainen , et al. · 2023

Importance A genetic contribution to preeclampsia susceptibility has been established but is still incompletely understood. Objective To disentangle the underlying genetic architecture of preeclampsia and preeclampsia or other maternal hyp…

Major Genetic Risk Factors for Dupuytren's Disease Are Inherited From Neandertals Open

Richard Ågren, Snehal Patil, Xiang Zhou, Aarno Palotie, Mark J. Daly , et al. · 2023

Dupuytren's disease is characterized by fingers becoming permanently bent in a flexed position. Whereas people of African ancestry are rarely afflicted by Dupuytren's disease, up to ∼30% of men over 60 years suffer from this condition in n…

Risk of Midlife Stroke After Adverse Pregnancy Outcomes: The FinnGen Study Open

Eliza C. Miller, Anni Kauko, Sarah E. Tom, Hannele Laivuori, Teemu Niiranen , et al. · 2023

BACKGROUND: Adverse pregnancy outcomes (APO) contribute to higher risk of maternal cerebrovascular disease, but longitudinal data that include APO and stroke timing are lacking. We hypothesized that APO are associated with younger age at f…

Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy Open

Hanna M. Ollila, Eilon Sharon, Ling Lin, Nasa Sinnott-Armstrong, Aditya Ambati , et al. · 2023

Diagnostic Performance and Tolerability of Saliva and Nasopharyngeal Swab Specimens in the Detection of SARS-CoV-2 by RT-PCR Open

Jaakko Ahti, Riikka Österback, Anniina Keskitalo, Kati Mokkala, Siina Vidbäck , et al. · 2023

The extensive testing of SARS-CoV-2 is vital in controlling the spread of COVID-19. The reference standard for specimen collection is a nasopharyngeal swab (NPS).

Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population Open

Mitja Kurki, Juha Karjalainen, Priit Palta, Timo P. Sipilä, Kati Kristiansson , et al. · 2023

Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata Open

Eeva Sliz, Jaakko Tyrmi, Nilüfer Rahmioğlu, Krina T. Zondervan, Christian M. Becker , et al. · 2023

FinnGen provides genetic insights from a well-phenotyped isolated population Open

Mitja Kurki, Juha Karjalainen, Priit Palta, Timo P. Sipilä, Kati Kristiansson , et al. · 2023

Antimicrobial resistance prevalence of Escherichia coli and Staphylococcus aureus amongst bacteremic patients in Africa: a systematic review Open

Erastus Haindongo, Diana Ndakolo, Marius Hedimbi, Olli Vainio, Antti Hakanen , et al. · 2022

The pooled resistance rates indicate a concerning degree of methicillin-resistant and Extended Spectrum-ß-lactamase-producing pathogens. The paucity of AMR data also presents challenges for a comprehensive understanding of the situation in…

Appendiceal microbiome in uncomplicated and complicated acute appendicitis: A prospective cohort study Open

Sanja Vanhatalo, Eveliina Munukka, Teemu Kallonen, Suvi Sippola, Juha Grönroos , et al. · 2022

Background Uncomplicated and complicated acute appendicitis seem to be two different forms of this common abdominal emergency. The contribution of appendiceal microbiota to appendicitis pathogenesis has been suggested, but differences betw…

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