Explanipedia

Complex networks approach to study comorbidities in patients with unruptured intracranial aneurysms Open

Juri Kivelev, Ilkka Saarenpää, Antti Karlsson, Paride Crisafulli, Federico Musciotto , et al. · 2024

Characterization of clinicopathological features, treatment practices, and outcomes among Finnish advanced breast cancer patients in real-life clinical practice Open

Krista Heinolainen, Silva Saarinen, Simona Vertuani, Antti Ellonen, Antti Karlsson , et al. · 2023

Purpose In recent years, several new targeted therapies have emerged for advanced breast cancer (aBC). However, real-life data specific to aBC and different breast cancer subtypes are scarce. This retrospective cohort study was designed to…

Burden of idiopathic inflammatory rheumatic diseases in occupational healthcare: increased absenteeism and healthcare resource utilization Open

Liisa Ukkola‐Vuoti, Antti Karlsson, Samuli Tuominen, Mariann I. Lassenius, Jaakko Aaltonen , et al. · 2023

OBJECTIVES: Patients with idiopathic inflammatory rheumatic diseases (IIRD) often have decreased working capacity resulting in indirect costs. However, data on patients’ short-term sick leave has been limited. This retrospective cohort stu…

Smoking is an Independent Marker of Poor Prognosis in Cutaneous Melanoma Open

Kalle Mattila, Helmi Vihinen, Antti Karlsson, Heikki Minn, Pia Vihinen , et al. · 2023

Previous studies have suggested that persistent tobacco smoking impairs survival in cutaneous melanoma, but the effects of smoking and other prognostic factors have not been described in detail. This study examined the association of smoki…

Artificial intelligence for diagnosis and Gleason grading of prostate cancer: the PANDA challenge Open

Wouter Bulten, Kimmo Kartasalo, Po-Hsuan Cameron Chen, Peter Ström, Hans Pinckaers , et al. · 2022

Through a community-driven competition, the PANDA challenge provides a curated diverse dataset and a catalog of models for prostate cancer pathology, and represents a blueprint for evaluating AI algorithms in digital pathology.Artificial i…

Identification of metastatic primary cutaneous squamous cell carcinoma utilizing artificial intelligence analysis of whole slide images Open

Jaakko Knuutila, Pilvi Riihilä, Antti Karlsson, Mikko Tukiainen, Lauri Talve , et al. · 2022

Cutaneous squamous cell carcinoma (cSCC) harbors metastatic potential and causes mortality. However, clinical assessment of metastasis risk is challenging. We approached this challenge by harnessing artificial intelligence (AI) algorithm t…

Automated detection of pulmonary embolism from CT-angiograms using deep learning Open

Heidi Huhtanen, Mikko Nyman, Tarek Mohsen, Arho Virkki, Antti Karlsson , et al. · 2022

Background The aim of this study was to develop and evaluate a deep neural network model in the automated detection of pulmonary embolism (PE) from computed tomography pulmonary angiograms (CTPAs) using only weakly labelled training data. …

Impact of deep learning-determined smoking status on mortality of cancer patients: never too late to quit Open

Antti Karlsson, Antti Ellonen, Heikki Irjala, Vesa Väliaho, Kalle Mattila , et al. · 2021

BackgroundPersistent smoking after cancer diagnosis is associated with increased overall mortality (OM) and cancer mortality (CM). According to the 2020 Surgeon General's report, smoking cessation may reduce CM but supporting evidence is n…

The Gaucher earlier diagnosis consensus point-scoring system (GED-C PSS): Evaluation of a prototype in Finnish Gaucher disease patients and feasibility of screening retrospective electronic health record data for the recognition of potential undiagnosed patients in Finland Open

Markku J. Savolainen, Antti Karlsson, Samppa Rohkimainen, Iiro Toppila, Mariann I. Lassenius , et al. · 2021

Supplementary Material for: Are Breast Cancer Nomograms Still Valid to Predict the Need for Axillary Dissection? Open

V. Madekivi, Antti Karlsson, Pia Boström, Eeva Salminen · 2021

Background: Nomograms can help in estimating the nodal status among clinically node-negative patients. Yet their validity in external cohorts over time is unknown. If the nodal stage can be estimated preoperatively, the need …

Documentation of the patient’s smoking status in common chronic diseases – analysis of medical narrative reports using the ULMFiT based text classification Open

Eveliina Hirvonen, Antti Karlsson, Tarja Saaresranta, Tarja Laitinen · 2021

Ee found that smoking status was documented in 60% of patients with chronic disease and that the clinician had discussed smoking cessation in 49% of patients who were current smokers. ULMFiT-based classifier showed good/excellent performan…

Identification of Metastatic Primary Cutaneous Squamous Cell Carcinoma Utilizing Artificial Intelligence Analysis of Whole Slide Images Open

Jaakko Knuutila, Pilvi Riihilä, Antti Karlsson, Mikko Tukiainen, Lauri Talve , et al. · 2021

IL-6 and other biomarkers as predictors of severity in COVID-19 Open

Niklas Broman, Kaisa Rantasärkkä, Thijs Feuth, M. Valtonen, Matti Waris , et al. · 2020

IL-6 and CRP were the strongest predictors of severity in hospitalized patients with COVID-19.

Is sleep apnea a risk factor for Covid-19? findings from a retrospective cohort study Open

Thijs Feuth, Tarja Saaresranta, Antti Karlsson, Mika Valtonen, Ville Peltola , et al. · 2020

Background: In the early phase of the coronavirus disease-19 (Covid-19) pandemic, Southwest Finland remained relatively spared.By the 3 rd of May 2020, a total of 28 patients have been admitted to the Turku University Hospital.We explore b…

Tissue samples into digital images, interpreted by artificial intelligence Open

Ari Turunen, Antti Karlsson, Lila Kallio, Tommi Nyrönen · 2020

Turku University Hospital and Auria Biobank aim to have all tissue specimens in digital format. The samples would be scanned from glass slides, with diagnostics in pathology performed on computers. They will also develop artificial intelli…

High tumor mutation burden predicts favorable outcome among patients with aggressive histological subtypes of lung adenocarcinoma: A population-based single-institution study Open

Eva‐Maria Talvitie, Heikki Vilhonen, Samu Kurki, Antti Karlsson, Katri Orte , et al. · 2020

Is sleep apnoea a risk factor for Covid-19? Findings from a retrospective cohort study Open

Thijs Feuth, Tarja Saaresranta, Antti Karlsson, Mika Valtonen, Ville Peltola , et al. · 2020

Background: In the early phase of the coronavirus disease-19 (Covid-19) pandemic, Southwest Finland remained relatively spared. By the 3rd of May 2020, a total of 28 patients have been admitted to the Turku University Hospital. In this pap…

Can a machine-learning model improve the prediction of nodal stage after a positive sentinel lymph node biopsy in breast cancer? Open

V. Madekivi, Peter J. Boström, Antti Karlsson, Riikka Aaltonen, Eeva Salminen · 2020

Background: The current standard for evaluating axillary nodal burden in clinically node negative breast cancer is sentinel lymph node biopsy (SLNB). However, the accuracy of SLNB to detect nodal stage N2-3 remains debatable. Nomogr…

Development of self-assessed work ability among middle-aged asthma patients—a 10 year follow-up study Open

Eveliina Hirvonen, Antti Karlsson, Maritta Kilpeläinen, Ari Lindqvist, Tarja Laitinen · 2020

The prevalence of asthma has been growing among working age people over the last decades. In this study, we examine the development of Work Ability Score (WAS) among middle-aged asthmatics in a longitudinal setting, in order to find risk f…

The Burden Of Chronic Obstructive Pulmonary Disease (COPD) In Finland: Impact Of Disease Severity And Eosinophil Count On Healthcare Resource Utilization Open

Arja Viinanen, Mariann I. Lassenius, Iiro Toppila, Antti Karlsson, Lauri Veijalainen , et al. · 2019

This study demonstrated a substantial burden associated with severe and/or eosinophilic COPD for patients in Finland.

Genetic architecture of human plasma lipidome and its link to cardiovascular disease Open

Rubina Tabassum, Joel Rämö, Pietari Ripatti, Jukka Koskela, Mitja Kurki , et al. · 2019

The burden of adult asthma in Finland: impact of disease severity and eosinophil count on health care resource utilization Open

Arja Viinanen, Mariann I. Lassenius, Iiro Toppila, Antti Karlsson, Lauri Veijalainen , et al. · 2019

Objective: To describe health care resource utilization (HCRU) and associated costs in adult patients referred for specialist asthma care in Southwest Finland, by disease severity and blood eosinophil count (BEC).Methods: Thi…

Genetic architecture of human plasma lipidome and its link to cardiovascular disease Open

Rubina Tabassum, Joel Rämö, Pietari Ripatti, Jukka Koskela, Mitja Kurki , et al. · 2019

Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 ind…

Health care resource utilization and characteristics of patients with eosinophilic asthma in secondary health care in Finland Open

Mika J. Mäkelä, Helene Nordahl Christensen, Antti Karlsson, Sarang Rastogi, Kirsi Kettunen · 2018

Background: Eosinophilic airway inflammation is common in asthma patients and appears to be associated with severe exacerbations and loss of asthma control. Objective: To describe the resource utilization and clinical charact…

Quantitative Evaluation of 2 Scatter-Correction Techniques for <sup>18</sup>F-FDG Brain PET/MRI in Regard to MR-Based Attenuation Correction Open

Jarmo Teuho, Virva Saunavaara, Tuula Tolvanen, Terhi Tuokkola, Antti Karlsson , et al. · 2017

In PET, corrections for photon scatter and attenuation are essential for visual and quantitative consistency. MR attenuation correction (MRAC) is generally conducted by image segmentation and assignment of discrete attenuation coefficients…

Quantum Zeno-type effect and non-Markovianity in a three-level system Open

Antti Karlsson, Francesco Francica, Jyrki Piilo, Francesco Plastina · 2016

We study the coexistence of the quantum Zeno-type effect and non-Markovianity for a system decaying in a structured bosonic environment and subject to a control field. The interaction with the environment induces decay from the excited to …

Verifying the Quantumness of Bipartite Correlations Open

Claudio Carmeli, Teiko Heinosaari, Antti Karlsson, Jussi Schultz, Alessandro Toigo · 2016

Entanglement is at the heart of most quantum information tasks, and therefore considerable effort has been made to find methods of deciding the entanglement content of a given bipartite quantum state. Here, we prove a fundamental limitatio…

Non-Markovian dynamics in two-qubit dephasing channels with an application to superdense coding Open

Antti Karlsson, Henri Lyyra, Elsi-Mari Laine, Sabrina Maniscalco, Jyrki Piilo · 2016

We study the performance of two measures of non-Markovianity in detecting\nmemory effects in two-qubit dephasing channels. By combining independent\nMarkovian and non-Markovian noise on the qubits, our results show that the\ntrace distance…

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