Explanipedia

Genetic and environmental influences on educational disparities in adult weight change: an individual-based pooled analysis of 11 twin cohorts Open

A. Fernández, Gabin Drouard, Aline Jelenkovic, Corrado Fagnani, Virgilia Toccaceli , et al. · 2025

Introduction Educational attainment (EA) is negatively associated with body mass index (BMI) but less is known about the association between EA and adult BMI change. We analyzed the role of genetic and environmental factors in the associat…

Maternal Gestational Low‐Grade Inflammation and the Risk of Anorexia Nervosa in Daughters Open

Emma Saure, Pyry N. Sipilä, Cynthia M. Bulik, Eriika Santti, Heljä‐Marja Surcel , et al. · 2025

Objective Prenatal exposures have been suggested to have a programming effect on neural and metabolic development, which may affect the risk of eating disorders. We investigated the association between prospectively measured maternal gesta…

Data Resource Profile: The Finnish TwinRegistry Project. Open

Stephanie Zellers, Sarah Niemi de Paiva, Mikko Olkkonen, Hannu Karhunen, Terhi Maczulskij , et al. · 2025

The Older Finnish Twin Cohort was established 50 years ago and includes twins born in Finland before 1958. Members of the cohort have responded to detailed questionnaires about their health, habits, and lifestyle up to four times, in 1975,…

Data Resource Profile: The Finnish TwinRegistry Project Open

Stephanie Zellers, S. Niemi, Mikko Olkkonen, Hannu Karhunen, Terhi Maczulskij , et al. · 2025

The Older Finnish Twin Cohort was established 50 years ago and includes twins born in Finland before 1958. Members of the cohort have responded to detailed questionnaires about their health, habits, and lifestyle up to four times, in 1975,…

Neighborhood social structure in Sweden: A latent transition analysis using registry data from 1991 to 2020 Open

Anneli Andersson, Nilo Tayebi, Belma Isakovic, Henrik Larsson, Peter Larm , et al. · 2025

Biological and psychological protective factors against the intergenerational transmission of criminal convictions: A total population, sibling comparison study Open

Sofi Oskarsson, Catherine Tuvblad, Paul Lichtenstein, Henrik Larsson, Antti Latvala · 2025

Parental criminality is a risk factor for crime, but little is known about why some individuals exposed to this risk refrain from crime. We explored associations of resting heart rate (RHR), systolic blood pressure (SBP), cognitive ability…

The individual and joint associations of alcohol use and cigarette smoking in adolescence and early adulthood with psychological distress in midlife – a multicohort study Open

Noora Berg, Jenna Grundström, Sari Aaltonen, Antti Latvala, Jouko Miettunen , et al. · 2025

Background Alcohol and tobacco use are associated with later mental health and psychological well-being, yet the associations of combined use of alcohol and tobacco with psychological well-being throughout the life span remain understudied…

Use of systemic hormonal contraception and risk of depression: a registry-based study from Finland Open

Elena Toffol, Timo Partonen, Oskari Heikinheimo, Anna But, Antti Latvala , et al. · 2025

Data Resource Profile: The Finnish TwinRegistry Project Open

Stephanie Zellers, Sarah Niemi de Paiva, Mikko Olkkonen, Hannu Karhunen, Annina Ropponen , et al. · 2025

The Older Finnish Twin Cohort was established 50 years ago and includes twins born in Finland before 1958. Members of the cohort have responded to detailed questionnaires about their health, habits, and lifestyle up to four times, in 1975,…

Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes Open

Elham Assary, Jonathan R. I. Coleman, Gibran Hemani, Margot P. van de Weijer, Laurence J Howe , et al. · 2025

Protein Associations With Alcohol Consumption and Genetic Risk for Alcohol‐Related Sociomedical Conditions Open

Gabin Drouard, Teemu Palviainen, Chia‐Ling Kuo, Breno S. Diniz, Xiao-Ling Wang , et al. · 2025

Studies investigating proteomic associations with alcohol consumption and the genetic links of these proteins to alcohol‐related traits are scarce. The aims of our study were (1) to identify proteins associated with alcohol consumption and…

Associations Between a Genetic Liability Toward Externalizing and Behavioral Outcomes Spanning Toddlerhood Through Early Adulthood in Five Developmental Cohorts Open

Maia Choi, Holly E. Poore, Sarah J. Brislin, Peter B. Barr, Fazil Alıev , et al. · 2025

A genetic liability toward externalizing is associated a wide array of behaviors and psychiatric/substance use outcomes beginning as early as childhood and through emerging adulthood. The early emergence and breadth of behaviors associated…

Trajectories of genetic risk across dimensions of alcohol use behaviors Open

Jeanne E. Savage, Fazil Alıev, Peter B. Barr, Maia Choi, Gabin Drouard , et al. · 2025

Background Alcohol use behaviors (AUBs) manifest in a variety of normative and problematic ways across the life course, all of which are heritable. Twin studies show that genetic influences on AUBs change across development, but this is us…

Causally-informative analyses of the effect of job displacement on all-cause and specific-cause mortality from the 1990s Finnish recession until 2020: A population registry study of private sector employees Open

Stephanie Zellers, Elissar Azzi, Antti Latvala, Jaakko Kaprio, Terhi Maczulskij · 2025

Our analyses support the causal influence of job displacement on all-cause and specific-cause mortality, even up to 30 years after the recession; this risk varies by cause of death and by length of follow-up. Future work should evaluate st…

Alcohol use in Early Midlife: Findings from the Age 37 Follow-Up Assessment of the FinnTwin12 Cohort Open

Megan Cooke, Erin Lumpe, Mallory Stephenson, Mia Urjansson, Fazil Alıev , et al. · 2025

Genetic and environmental influences on alcohol consumption in middle to late life. Open

Daniel E. Gustavson, Tyler Bell, Erik Buchholz, Stephanie Zellers, Susan E. Luczak , et al. · 2025

This study represents the largest twin study of alcohol consumption in middle-aged and older adults. Results highlight that genetic and environmental factors influence alcohol consumption differently across age, sex, and educational attain…

Neighborhood Social Structure in Sweden: A Latent Transition Analysis Using Registry Data From 1991 To 2020 Open

Anneli Andersson, Nilo Tayebi, Belma Isakovic, Henrik Larsson, Peter Larm , et al. · 2025

Etiology and correlates of alcohol misuse in early midlife Open

Erin Lumpe, Angela Pascale, Mallory Stephenson, Peter B. Barr, Megan Cooke , et al. · 2024

Background Early midlife individuals (ages 30–40) experience demographic shifts that may influence the remainder of adult life. Although new or persistent alcohol misuse is common during this period, early midlife is understudied in alcoho…

Dimensional attention-deficit/hyperactivity disorder symptoms and executive functioning in adolescence: A multi-informant, population-based twin study. Open

Laila Ketvel, Eero Vuoksimaa, Lea Pulkkinen, Richard J. Rose, Ulla Vedenkannas , et al. · 2024

Even at a subclinical level in a sample of adolescents representing general population, ADHD symptoms are associated with EF performance. Teachers' evaluations appear especially valuable when assessing adolescents' ADHD symptoms. Our findi…

Family-GWAS reveals effects of environment and mating on genetic associations Open

Tammy Tan, Hariharan Jayashankar, Junming Guan, Seyed Moeen Nehzati, Mahdi Mir , et al. · 2024

Genome–wide association studies (GWAS) have discovered thousands of replicable genetic associations, guiding drug target discovery and powering genetic prediction of human phenotypes and diseases. However, genetic associations can be affec…

Parental incarceration and offspring criminality: A Finnish total population study with sibling comparison Open

Ilona Nissinen, Antti Latvala, Karoliina Suonpää, Mikko Aaltonen, Pekka Martikainen · 2024

Maternal sex-hormone exposure and the risk of eating disorders in daughters Open

Emma Saure, Pyry N. Sipilä, Heljä-Maria Surcel, Antti Latvala, Anni Heiskala , et al. · 2024

Potential effects of prenatal sex hormones on later eating disorders in offspring have been investigated with two indirect methods (finger length ratio, opposite- versus same-sex twins). We utilized a direct, prospective method, examining …

Use of systemic hormonal contraception and risk of attempted suicide: a nested case–control study Open

Elena Toffol, Timo Partonen, Oskari Heikinheimo, Anna But, Antti Latvala , et al. · 2024

Evidence regarding the role of hormonal contraception (HC) as a risk factor for attempted suicide is inconclusive. Thus, this study aimed to assess the associations of use of different types of systemic HC with the risk of attempted suicid…

Causally-informative analyses of the effect of job displacement on all-cause and specific-cause mortality from the 1990s Finnish recession until 2020: A population registry study Open

Stephanie Zellers, Elissar Azzi, Antti Latvala, Jaakko Kaprio, Terhi Maczulskij · 2024

Background Job loss is related to morbidity and mortality, but generation of causal evidence is challenging due to confounding factors. Finland suffered a severe economic recession in the early 1990s with unemployment reaching almost 25%, …

Association between adolescent alcohol use and cognitive function in young adulthood: A co‐twin comparison study Open

Megan Cooke, Mallory Stephenson, Sarah J. Brislin, Antti Latvala, Peter B. Barr , et al. · 2024

Background and Aims Studies on adolescent alcohol use and cognition are often unable to separate the potential causal effects of alcohol use on cognition from shared etiological influences, including genetic influences or other substance u…

Associations Between a Genetic Liability Toward Behavioral Disinhibition and Externalizing Outcomes Spanning Toddlerhood Through Early Adulthood in Five Developmental Cohorts Open

Maia Choi, Holly E. Poore, Sarah J. Brislin, Fazil Alıev, Stephanie Zellers , et al. · 2024

Objective: Understanding how genetic risk unfolds across development will be important for using genetics to inform prevention and early intervention. The current study leverages information from five large datasets to characterize behavio…

Health, behavior, and social outcomes among offspring of parents with criminal convictions: a register‐based study from Sweden Open

A Järvinen, Paul Lichtenstein, Brian M. D’Onofrio, Seena Fazel, Ralf Kuja‐Halkola , et al. · 2024

Background There is currently insufficient understanding of the health and behavior of children whose parents engage in criminal behavior. We examined associations between parental criminal convictions and wide range of offspring health, b…

Associations of Romantic Partners’ Characteristics with Alcohol Consumption and Binge Drinking: Examining Evidence for Gene-Environment Interaction Open

Mallory Stephenson, Megan Cooke, Peter B. Barr, Hermine H. Maes, Antti Latvala , et al. · 2024

We investigated associations of romantic partners’ alcohol use, cigarette smoking, personality, and psychological distress with alcohol use and binge drinking within a sample of Finnish twins (N = 1620, 51% female, mean age = 33.6 years) a…

Genetics of environmental sensitivity to psychiatric and neurodevelopmental phenotypes: evidence from GWAS of monozygotic twins Open

Elham Assary, Jonathan R. I. Coleman, Gibran Hemani, Margot van Der Veijer, Laurence J Howe , et al. · 2024

Cohort Effects on Tobacco Consumption and Its Genetic and Environmental Variance Among Finnish Adults Born Between 1880 and 1957 Open

Stephanie Zellers, Hermine H. Maes, Antti Latvala, Jaakko Kaprio · 2024

Introduction Population research indicates that smoking behaviors in Finland have varied over time by sex and birth cohort. Smoking behaviors are influenced by genes and the environment; like the behaviors themselves, these underlying infl…

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