Antti Lauerma
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View article: Impact of Residential Greeness Exposure on the Development of Allergic Diseases and Asthma and on Asthma Control—A Systematic Review for the <scp>EAACI</scp> Guidelines of Environmental Science for Allergic Diseases and Asthma
Impact of Residential Greeness Exposure on the Development of Allergic Diseases and Asthma and on Asthma Control—A Systematic Review for the <span>EAACI</span> Guidelines of Environmental Science for Allergic Diseases and Asthma Open
The role of residential greenness exposure (RGE) in prevention and control of allergic diseases remains controversial. This systematic review evaluated the association between RGE and the risk of developing asthma, allergic rhinitis (AR), …
View article: Taxonomic and functional profiling of skin microbiome in psoriasis
Taxonomic and functional profiling of skin microbiome in psoriasis Open
This research utilizes whole metagenomic shotgun sequencing to analyse the skin microbiome in patients with psoriasis, comparing lesional and nonlesional skin with those of healthy individuals. The study identifies significant differences …
View article: The epithelial barrier theory and its associated diseases
The epithelial barrier theory and its associated diseases Open
The prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, over 350,000 new chemical substances have been introduced to the lives of humans. In recent years, the epithelial…
View article: Exploratory multi-omics analysis reveals host-microbe interactions associated with disease severity in psoriatic skin
Exploratory multi-omics analysis reveals host-microbe interactions associated with disease severity in psoriatic skin Open
The research has received funding from the FP7 (MAARS-Grant 261366) and the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 821511 (BIOMAP). The JU receives support from the European Union's Horizon 2020 r…
View article: Międzynarodowe wytyczne EAACI/GA2LEN/EuroGuiDerm/APAAACI dotyczące definicji, klasyfikacji, diagnostyki i leczenia pokrzywki
Międzynarodowe wytyczne EAACI/GA2LEN/EuroGuiDerm/APAAACI dotyczące definicji, klasyfikacji, diagnostyki i leczenia pokrzywki Open
Niniejsza aktualizacja i rewizja międzynarodowych wytycznych dotyczących pokrzywki została opracowana zgodnie z metodami zalecanymi przez Cochrane i grupę roboczą Grading of Recommendations Assessment, Development and Evaluation (GRADE). J…
View article: Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An <scp>EAACI</scp> position paper
Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An <span>EAACI</span> position paper Open
The exponential growth of precision diagnostic tools, including omic technologies, molecular diagnostics, sophisticated genetic and epigenetic editing, imaging and nano‐technologies and patient access to extensive health care, has resulted…
View article: Effects of incubation temperature and maternal phenotype on Baltic herring (<i>Clupea harengus membras</i>) eggs and larvae: an experimental study
Effects of incubation temperature and maternal phenotype on Baltic herring (<i>Clupea harengus membras</i>) eggs and larvae: an experimental study Open
Temperature modifies the reproductive success of fish, yet, in many species, we lack the information on its role in the early development. In this study, the effect of temperature on the relation between maternal traits (length, age, somat…
View article: Topical probiotic L. lactis treatment in atopic dermatitis - A double-blinded, placebo-controlled pilot study
Topical probiotic L. lactis treatment in atopic dermatitis - A double-blinded, placebo-controlled pilot study Open
Topical probiotic L. lactis treatment in atopic dermatitis - A double-blinded, placebo-controlled pilot studyTo the Editor,Changes in the skin microbiome have been identified as major pathogenetic components in atopic dermatitis (AD). Prob…
View article: Treatment of atopic dermatitis with probiotic L. lactis lysate - A double-blinded, placebo-controlled pilot study
Treatment of atopic dermatitis with probiotic L. lactis lysate - A double-blinded, placebo-controlled pilot study Open
Background: Microbiome-targeted treatments have been investigated in atopic dermatitis (AD). We aimed to investigate the use of probiotic Lactococcus lactis lysate cream in AD. Methods: 13 patients with mild-to-moderate AD were treated wit…
View article: Machine-Learning-Driven Biomarker Discovery for the Discrimination between Allergic and Irritant Contact Dermatitis
Machine-Learning-Driven Biomarker Discovery for the Discrimination between Allergic and Irritant Contact Dermatitis Open
Contact dermatitis tremendously impacts the quality of life of suffering patients. Today diagnostic regimes rely on allergy testing, exposure specification, and follow-up visits; however, distinguishing the clinical phenotype of irritant a…
View article: Factors associated with severity of atopic dermatitis – a Finnish cross‐sectional study
Factors associated with severity of atopic dermatitis – a Finnish cross‐sectional study Open
Background Severity‐associated factors in atopic dermatitis (AD) have focussed on early onset, concomitant atopic diseases, markers of Th2‐shifted inflammation and filaggrin mutations. Objectives To investigate factors associated with seve…
View article: Age-dependent Distribution of Atopic Dermatitis in Primary Care: A Nationwide Population-based Study from Finland
Age-dependent Distribution of Atopic Dermatitis in Primary Care: A Nationwide Population-based Study from Finland Open
The burden of atopic dermatitis (AD) appears to be increasing in adult and elderly patients. The aim of this study was to analyse the nationwide database of the Finnish Institute for Health and Welfare regarding the number of patients with…
View article: Effects of Bifidobacterium animalis subsp. lactis Bl-04 on Skin Wrinkles and Dryness: A Randomized, Triple-Blinded, Placebo-Controlled Clinical Trial
Effects of Bifidobacterium animalis subsp. lactis Bl-04 on Skin Wrinkles and Dryness: A Randomized, Triple-Blinded, Placebo-Controlled Clinical Trial Open
The effects of orally consumed probiotics on skin wrinkles and dryness are not fully known. A randomized, placebo-controlled, triple-blinded study was conducted with 148 healthy Korean female volunteers aged between 33 and 60 years, who we…
View article: Influence of FLG loss-of-function mutations in host–microbe interactions during atopic skin inflammation
Influence of FLG loss-of-function mutations in host–microbe interactions during atopic skin inflammation Open
View article: Transcriptomic Profiling of Adult-Onset Asthma Related to Damp and Moldy Buildings and Idiopathic Environmental Intolerance
Transcriptomic Profiling of Adult-Onset Asthma Related to Damp and Moldy Buildings and Idiopathic Environmental Intolerance Open
A subset of adult-onset asthma patients attribute their symptoms to damp and moldy buildings. Symptoms of idiopathic environmental intolerance (IEI) may resemble asthma and these two entities overlap. We aimed to evaluate if a distinct cli…
View article: The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria
The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria Open
This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a join…
View article: COVID-19-vaccination in patients receiving allergen immunotherapy (AIT) or biologics - EAACI recommendations
COVID-19-vaccination in patients receiving allergen immunotherapy (AIT) or biologics - EAACI recommendations Open
Immune modulation is a key therapeutic tool for allergic diseases and asthma. It can be achieved in an antigen-specific way via allergen immunotherapy (AIT) or in endotype-driven approach using biologicals that target the major pathways of…
View article: ARIA‐EAACI care pathways for allergen immunotherapy in respiratory allergy
ARIA‐EAACI care pathways for allergen immunotherapy in respiratory allergy Open
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View article: Management of anaphylaxis due to COVID‐19 vaccines in the elderly
Management of anaphylaxis due to COVID‐19 vaccines in the elderly Open
Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID‐19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID‐19 v…
View article: COVID‐19 pandemic and allergen immunotherapy—an EAACI survey
COVID‐19 pandemic and allergen immunotherapy—an EAACI survey Open
Background As in many fields of medical care, the coronavirus disease 2019 (COVID‐19) resulted in an increased uncertainty regarding the safety of allergen immunotherapy (AIT). Therefore, the European Academy of Allergy and Clinical Immuno…
View article: Interplay between skin microbiota and immunity in atopic individuals
Interplay between skin microbiota and immunity in atopic individuals Open
The prevalence of allergic diseases continues to increase worldwide along with industrialization and urbanization. Emerging evidence provides insights into the connection between the development of chronic inflammatory disorders, such as a…
View article: COVID‐19 pandemic: Practical considerations on the organization of an allergy clinic—An EAACI/ARIA Position Paper
COVID‐19 pandemic: Practical considerations on the organization of an allergy clinic—An EAACI/ARIA Position Paper Open
Background The coronavirus disease 2019 (COVID‐19) has evolved into a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS‐CoV‐2). Allergists and other healthcare providers (HCPs) in the field …
View article: Skin Microbiome in Cutaneous T-Cell Lymphoma by 16S and Whole-Genome Shotgun Sequencing
Skin Microbiome in Cutaneous T-Cell Lymphoma by 16S and Whole-Genome Shotgun Sequencing Open
View article: Prioritizing Research Challenges and Funding for Allergy and Asthma and the Need for Translational Research — The European Strategic Forum on Allergic Diseases
Prioritizing Research Challenges and Funding for Allergy and Asthma and the Need for Translational Research — The European Strategic Forum on Allergic Diseases Open
The European Academy of Allergy and Clinical Immunology (EAACI) organized the first European Strategic Forum on Allergic Diseases and Asthma. The main aim was to bring together all relevant stakeholders and decision‐makers in the field of …
View article: Ihon mikrobiston merkitys atooppisessa ekseemassa ja psoriaasissa tarkentuu
Ihon mikrobiston merkitys atooppisessa ekseemassa ja psoriaasissa tarkentuu Open
View article: Microbe-host interplay in atopic dermatitis and psoriasis
Microbe-host interplay in atopic dermatitis and psoriasis Open
Despite recent advances in understanding microbial diversity in skin homeostasis, the relevance of microbial dysbiosis in inflammatory disease is poorly understood. Here we perform a comparative analysis of skin microbial communities coupl…
View article: Prioritizing research challenges and funding for allergy and asthma and the need for translational research—The European Strategic Forum on Allergic Diseases
Prioritizing research challenges and funding for allergy and asthma and the need for translational research—The European Strategic Forum on Allergic Diseases Open
The European Academy of Allergy and Clinical Immunology (EAACI) organized the first European Strategic Forum on Allergic Diseases and Asthma. The main aim was to bring together all relevant stakeholders and decision‐makers in the field of …
View article: Chlamydiales Bacterial Sequences in Lesional and Healthy Skin of Patients with Parapsoriasis
Chlamydiales Bacterial Sequences in Lesional and Healthy Skin of Patients with Parapsoriasis Open
View article: Isotretinoin and lymecycline treatments modify the skin microbiota in acne
Isotretinoin and lymecycline treatments modify the skin microbiota in acne Open
Oral retinoids and tetracyclines have a major role in acne treatment. Here, we report for the first time the effect of isotretinoin and lymecycline therapy on the skin microbiota in cheek, back and armpit swab samples of acne vulgaris pati…
View article: Loss of cutaneous microbial diversity during first 3 weeks of life in very low birthweight infants
Loss of cutaneous microbial diversity during first 3 weeks of life in very low birthweight infants Open
Neonatal sepsis ( NS ) is a frequent problem in neonatal intensive care, especially in preterm and very low birthweight ( VLBW ) infants. The objective of the study was to characterize the cutaneous bacterial microbiome in VLBW infants tre…