Anu Laitala
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View article: Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade
Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade Open
Pancreatic ductal adenocarcinoma (PDAC) patients have a 5-year survival rate of only 8% largely due to late diagnosis and insufficient therapeutic options. Neutrophils are among the most abundant immune cell type within the PDAC tumor micr…
View article: Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in<i>FoxD1</i>-lineage mesenchymal cells leads to congenital truncal alopecia
Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in<i>FoxD1</i>-lineage mesenchymal cells leads to congenital truncal alopecia Open
Hypoxia-inducible factors (HIFs) induce hundreds of genes regulating oxygen homeostasis in tissues. Oxygen sensors of the cells, the HIF prolyl 4-hydroxylases (HIF-P4Hs), regulate the stability and activity of HIFs in an oxygen-dependent m…
View article: Hypoxic Signalling in Tumour Stroma
Hypoxic Signalling in Tumour Stroma Open
Hypoxia is a common feature in solid tumors and is associated with cancer progression. The main regulators of the hypoxic response are hypoxia-inducible transcription factors (HIFs) that guide the cellular adaptation to hypoxia by gene act…