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View article: Characterization of five environmental phages infecting <i>Escherichia coli</i> K-12 isolated during a phage biology training course
Characterization of five environmental phages infecting <i>Escherichia coli</i> K-12 isolated during a phage biology training course Open
Phage collections are essential tools for discovering and dissecting bacterial anti-phage defense systems. Here, we report the isolation, characterization, and annotated genome sequences of five environmental Escherichia coli -infecting ph…
View article: Anomalous Oligomerization Behavior of E. coli Aquaporin Z in Detergent and in Nanodiscs
Anomalous Oligomerization Behavior of E. coli Aquaporin Z in Detergent and in Nanodiscs Open
Aquaporins are tetrameric integral membrane proteins that act as water channels, and can also permeabilize membranes to other solutes. The monomer appears to be the functional form despite all aquaporins being organized as tetramers, which…
View article: Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels
Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels Open
Voltage-gated potassium (Kv) channels modulate the function of electrically-excitable and non-excitable cells by using several types of “gates” to regulate ion flow through the channels. An important gating mechanism, C-type inactivation, …
View article: Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug
Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug Open
Significance Voltage-gated potassium channels (Kv) open with membrane depolarization and allow the flow of K + ions. Ion flow is tightly governed by time-dependent entry into nonconducting inactivated states. Here, we focus on Kv1.3, a cha…