Anudeep Yekula
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View article: EPID-05. PATTERNS OF RECOMMENDATION FOR SURGICAL INTERVENTION IN GRADE II, III, AND IV ASTROCYTOMAS: IMPLICATIONS FOR DELAYED DIAGNOSIS AND TREATMENT
EPID-05. PATTERNS OF RECOMMENDATION FOR SURGICAL INTERVENTION IN GRADE II, III, AND IV ASTROCYTOMAS: IMPLICATIONS FOR DELAYED DIAGNOSIS AND TREATMENT Open
INTRODUCTION Timely surgical acquisition of tumor tissue for definitive diagnosis forms the foundation for early cancer diagnosis and treatment. Here we examined the pattern of surgical recommendations in the treatment of intracranial astr…
View article: The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring
The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring Open
The emerging field of liquid biopsy stands at the forefront of novel diagnostic strategies for cancer and other diseases. Liquid biopsy allows minimally invasive molecular characterization of cancers for diagnosis, patient stratification t…
View article: Systematic Review of Photodynamic Therapy in Gliomas
Systematic Review of Photodynamic Therapy in Gliomas Open
Over the last 20 years, gliomas have made up over 89% of malignant CNS tumor cases in the American population (NIH SEER). Within this, glioblastoma is the most common subtype, comprising 57% of all glioma cases. Being highly aggressive, th…
View article: Systematic review of photodynamic therapy in gliomas
Systematic review of photodynamic therapy in gliomas Open
Over the last 20 years, gliomas have made up over 89% of malignant CNS tumor cases in the American population (NIH SEER). Within this, glioblastoma is the most common subtype, comprising 57% of all glioma cases. Highly aggressive, this dea…
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Table 1
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Table 3
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Figure 1. (a) Schematic depicting 2D amplitude differentiation between mutually exclusive C228T and C250T mutations
View article: Supplementary File description from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary File description from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary File Figure legends
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Figure 3. Tumor Tissue Analysis and Analysis of plasma TERT in Copies/mL.
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Figure 2. R-based gating setting and detection of TERT Promoter Mutation in Plasma of Discovery, Validation and Multi-Institution Cohorts
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Table 1
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Figure 2. R-based gating setting and detection of TERT Promoter Mutation in Plasma of Discovery, Validation and Multi-Institution Cohorts
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Table 2
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Figure 1. (a) Schematic depicting 2D amplitude differentiation between mutually exclusive C228T and C250T mutations
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Table 2
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Figure 4. Correlations between (a) progression free survival, (b) overall survival, (c) tumor grade, (d) contrast enhancement, (e) type of TERT mutation, (f) tumor volume, (g) duration of disease, (h) age. Contingency tables …
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Figure 4. Correlations between (a) progression free survival, (b) overall survival, (c) tumor grade, (d) contrast enhancement, (e) type of TERT mutation, (f) tumor volume, (g) duration of disease, (h) age. Contingency tables …
View article: Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Purpose:Liquid biopsy offers a minimally invasive tool to diagnose and monitor the heterogeneous molecular landscape of tumors over time and therapy. Detection of TERT promoter mutations (C228T, C250T) in cfDNA has bee…
View article: Supplementary File description from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary File description from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary File Figure legends
View article: Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Purpose:Liquid biopsy offers a minimally invasive tool to diagnose and monitor the heterogeneous molecular landscape of tumors over time and therapy. Detection of TERT promoter mutations (C228T, C250T) in cfDNA has bee…
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Figure 3. Tumor Tissue Analysis and Analysis of plasma TERT in Copies/mL.
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Table 3
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Table 1
View article: Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
Supplementary Data from <i>TERT</i> Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas Open
Supplementary Table 1
View article: Direct stick embolization of a rectal venous malformation via transanal minimally invasive surgery
Direct stick embolization of a rectal venous malformation via transanal minimally invasive surgery Open
Rectal venous malformations (VMs) are rare clinical entities with variable patterns of presentation. Treatment requires unique, targeted strategies based on the symptoms, associated complications, and location, depth, and extent of the les…
View article: Neurosurgery Residency Match for International Medical Graduates (IMGs) in the United States (U.S.)
Neurosurgery Residency Match for International Medical Graduates (IMGs) in the United States (U.S.) Open
Review question / Objective: Training of international medical graduates (IMGs) offers opportunities for the United States (U.S.) neurosurgery community to engage the global talent pool and impact national and international healthcare.Howe…
View article: Longitudinal analysis of serum-derived extracellular vesicle RNA to monitor dacomitinib treatment response in EGFR-amplified recurrent glioblastoma patients
Longitudinal analysis of serum-derived extracellular vesicle RNA to monitor dacomitinib treatment response in EGFR-amplified recurrent glioblastoma patients Open
Background Glioblastoma (GBM) is a highly aggressive and invasive brain tumor associated with high patient mortality. A large fraction of GBM tumors have been identified as epidermal growth factor receptor (EGFR) amplified and ~50% also ar…
View article: Glioblastoma‐derived extracellular vesicle subpopulations following 5‐aminolevulinic acid treatment bear diagnostic implications
Glioblastoma‐derived extracellular vesicle subpopulations following 5‐aminolevulinic acid treatment bear diagnostic implications Open
Liquid biopsy is a minimally invasive alternative to surgical biopsy, encompassing different analytes including extracellular vesicles (EVs), circulating tumour cells (CTCs), circulating tumour DNA (ctDNA), proteins, and metabolites. EVs a…
View article: Single-Cell RNA Sequencing of Cerebrospinal Fluid as an Advanced Form of Liquid Biopsy for Neurological Disorders
Single-Cell RNA Sequencing of Cerebrospinal Fluid as an Advanced Form of Liquid Biopsy for Neurological Disorders Open
Diagnosis and longitudinal monitoring of neurological diseases are limited by the poor specificity and limited resolution of currently available techniques. Analysis of circulating cells in cerebrospinal fluid (CSF) has emerged as a promis…
View article: BIOM-12. DEVELOPMENT OF 5-ALA BASED LIQUID BIOPSY FOR THE NON-INVASIVE DIAGNOSIS OF GLIOBLASTOMA
BIOM-12. DEVELOPMENT OF 5-ALA BASED LIQUID BIOPSY FOR THE NON-INVASIVE DIAGNOSIS OF GLIOBLASTOMA Open
INTRODUCTION Tumor specificity of 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX (PpIX) fluorescence is widely applied for fluorescence-guided surgery (FGS) in gliomas. We recently showed the feasibility of detecting tumour-specif…