Ashutosh Singh
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View article: Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells
Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells Open
The USP37 gene encodes a deubiquitylase (DUB), which catalyzes the proteolytic removal of ubiquitin moieties from proteins to modulate their stability, cellular localization or activity. Its expression is downregulated in a subgroup of med…
View article: Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells
Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells Open
USP37 gene encodes a deubiquitylase (DUB), which catalyzes the proteolytic removal of ubiquitin moieties from proteins to modulate their stability, cellular localization or activity. Its expression is downregulated in a subgroup of medullo…
View article: Exploring the Efficacy of Sulphonamide in Novel Therapeutic Approaches: New Hope
Exploring the Efficacy of Sulphonamide in Novel Therapeutic Approaches: New Hope Open
Sulphonamides are widely used in medicine for their antibacterial, antifungal, antiviral, antitumor, anti-inflammatory, and carbonic anhydrase-inhibiting properties. They can block protein and nucleic acid production in bacteria. Adding ar…
View article: A Comprehensive Review of Water Treatment Methods for Heavy Metal Ion Removal from Wastewater
A Comprehensive Review of Water Treatment Methods for Heavy Metal Ion Removal from Wastewater Open
Wastewater pollution with heavy metals presents serious problems with not only environmental integrity but also human health safety. This review is a complete review that includes different removal methods and technologies for heavy metals…
View article: A comprehensive insight on the challenges for COVID-19 vaccine: A lesson learnt from other viral vaccines
A comprehensive insight on the challenges for COVID-19 vaccine: A lesson learnt from other viral vaccines Open
The aim of this study is to comprehensively analyze previous viral vaccine programs and identify potential challenges and effective measures for the COVID-19 vaccine program. Previous viral vaccine programs, such as those for HIV, Zika, In…
View article: Structural-Based Virtual Screening of FDA-Approved Drugs Repository for NSP16 Inhibitors, Essential for SARS-COV-2 Invasion Into Host Cells: Elucidation From MM/PBSA Calculation
Structural-Based Virtual Screening of FDA-Approved Drugs Repository for NSP16 Inhibitors, Essential for SARS-COV-2 Invasion Into Host Cells: Elucidation From MM/PBSA Calculation Open
NSP16 is one of the structural proteins of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) necessary for its entrance to the host cells. It exhibits 2’O-methyl-transferase (2’O-MTase) activity of NSP16 using methyl group f…
View article: Trade of Indian Peafowl <i>Pavo cristatus</i> Feathers on E-commerce Websites in India
Trade of Indian Peafowl <i>Pavo cristatus</i> Feathers on E-commerce Websites in India Open
Trade in wildlife body parts is among the major sources of income for many tribal communities in India. Most of this trade is banned or restricted under the Indian Wild Life (Protection) Act, 1972, but some items are permitted with clause(…
View article: Short- and long-term safety and efficacy of corneal collagen cross-linking in progressive keratoconus: A systematic review and meta-analysis of randomized controlled trials
Short- and long-term safety and efficacy of corneal collagen cross-linking in progressive keratoconus: A systematic review and meta-analysis of randomized controlled trials Open
PURPOSE: The purpose of the study is to evaluate the safety and outcomes of corneal collagen cross-linking (CXL) and different CXL protocols in progressive keratoconus (PK) population at short and long-term. MATERIALS AND METHODS: A system…
View article: A novel inhibitor L755507 efficiently blocks c-Myc–MAX heterodimerization and induces apoptosis in cancer cells
A novel inhibitor L755507 efficiently blocks c-Myc–MAX heterodimerization and induces apoptosis in cancer cells Open
c-Myc is a transcription factor that plays a crucial role in cellular homeostasis, and its deregulation is associated with highly aggressive and chemotherapy-resistant cancers. After binding with partner MAX, the c-Myc-MAX heterodimer regu…
View article: Promising traditional Indian medicinal plants for the management of novel Coronavirus disease: A systematic review
Promising traditional Indian medicinal plants for the management of novel Coronavirus disease: A systematic review Open
Traditional Indian medical practices (Ayurveda, Siddha, Unani, and homeopathy) are a vast reservoir of knowledge about medicinal plants. The promising pharmacological properties of these plants have paved the way for developing therapy aga…
View article: Role of BCG in Reduction of the Spread and Severity of COVID-19
Role of BCG in Reduction of the Spread and Severity of COVID-19 Open
Bacille Calmette Guerin (BCG) vaccine has existence of more than 80 years with its widest use among all currently available vaccines. BCG vaccine developed from a virulent attenuated M. bovis strain against tuberculosis (TB) by deleting mo…
View article: Virological and clinical cure in COVID‐19 patients treated with hydroxychloroquine: A systematic review and meta‐analysis
Virological and clinical cure in COVID‐19 patients treated with hydroxychloroquine: A systematic review and meta‐analysis Open
Following the demonstration of the efficacy of hydroxychloroquine against severe acute respiratory syndrome coronavirus 2 in vitro, many trials started to evaluate its efficacy in clinical settings. However, no systematic review and meta‐a…
View article: Acoustic Cavitation-Assisted Formulation of Solid Lipid Nanoparticles using Different Stabilizers
Acoustic Cavitation-Assisted Formulation of Solid Lipid Nanoparticles using Different Stabilizers Open
Because of excellent bioavailability and high biocompatibility, solid lipid nanoparticles (SLNs) have gained attention in recent years, especially in drug delivery systems. SLNs are composed of a drug that is loaded in a lipid matrix and s…
View article: Molecular characterization by using 12SrRNA and Cytochrome b for identification of species of genus<i>Ratufa</i>(Rodentia: Scuiridae) including<i>Ratufa indica</i>, endemic species of India
Molecular characterization by using 12SrRNA and Cytochrome b for identification of species of genus<i>Ratufa</i>(Rodentia: Scuiridae) including<i>Ratufa indica</i>, endemic species of India Open
Oriental giant squirrels are tree squirrels classified under family Ratufinae. In India, there are three species of genus Ratufa, i.e. Ratufa bicolor, Ratufa macroura and Ratufa indica. They are also distributed in South and Southeast Asia…
View article: An Epidemiological study and analysis of prognostic factors of testicular carcinoma
An Epidemiological study and analysis of prognostic factors of testicular carcinoma Open
Background: Testicular carcinoma is an uncommon malignancy overall accounting for 1-2% of all tumours in men, testicular cancer is the most common malignancy in young men.The aim of the study was to analysis of prognostic factor of testicu…
View article: Novel therapeutic targets for amyotrophic lateral sclerosis
Novel therapeutic targets for amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis (ALS) is an untreatable and fatal neurodegenerative disease that is identified by the loss of motor neurons in the spinal cord, brain stem, and motor cortex which theatrically reduces life expectancy. Although…