Explanipedia

Flexible Titanium Nailing Versus Casting of Closed Unstable Tibial Shaft Fracture in Children and Adolescent Open

Anup Ghosh, Mohammad Abdul Hye, Khaled Ibney Anwar, Syed Ariful Islam, Shaon Barua , et al. · 2025

Background: Casting is the standard method of treatment for pediatric diaphyseal fracture of tibia. It has some limitations in treating an unstable fracture. Various options are available but still debate on optimal treatment strategy in 8…

There is more to it than just adoption: Exploring agricultural mechanisation journeys in South Asia Open

Brendan Brown, Pragya Timsina, Anjana Chaudhary, Emma Karki, Arpita Sharma , et al. · 2025

Refractory mycotic keratitis by Cephalotheca foveolata: first report from India Open

Harsimran Kaur, Imola Jamir, Deeksha Sharma, Haseen Ahmad, Ankita Saroya , et al. · 2025

Direct Identification of Yeasts from Blood Cultures and Body Fluids Using MALDI-TOF MS with Concurrent Antifungal Susceptibility Testing Open

Arpita Khamrai, Snigdha Reddy, Saikat Paul, Ankita Saroya, Shristi Verma , et al. · 2025

The rising incidence of invasive fungal infections has been accompanied by an increasing prevalence of antifungal resistance among fungal pathogens. Rapid identification of causative agents and their antifungal susceptibility profiles is c…

Genotypic Diversity and Molecular Basis of Fluconazole Resistance in Candida parapsilosis Clinical Isolates Collected Over 7 Years in a Tertiary‐Care Hospital in North India Open

Vrinda Sharma, Sourav Kumar Das, Bram Spruijtenburg, Theun de Groot, Eelco F. J. Meijer , et al. · 2025

Background The recent rise in the global incidence of fluconazole resistance in C. parapsilosis has become a significant public health concern. Epidemiological studies suggest that fluconazole resistance in C. parapsilosis spreads through …

Papulaspora equi keratitis in an infant Open

Harsimran Kaur, Imola Jamir, Sonam Yangzes, Haseen Ahmad, Sourav Agnihotri , et al. · 2024

Evaluation of VITEK MS Version 3.0 MALDI-TOF for the identification of anaerobes, mycobacteria, Nocardia, and moulds Open

Kusum Sharma, Archana Angrup, Anup Ghosh, Shreya Singh, Anshul Sood , et al. · 2024

An upgraded VITEK MS V3.0 database provides reasonably accurate and rapid identification of clinically relevant anaerobes, mycobacteria, Nocardia species, and moulds to the species level.

An interesting report of COVID-19 associated mucormycosis (CAM) cases by two different species of Mucorales Open

Harsimran Kaur, Rimjhim Kanaujia, Gyanaranjan Nayak, Anurag Snehi Ramavat, Sourabha Kumar Patro , et al. · 2024

During surge of COVID-19-associated mucormycosis (CAM), we identified five cases of CAM where two different species of Mucorales were isolated. All had history of diabetes mellitus and presented with clinical features suggesting rhino-orbi…

Comparative fitness trade-offs associated with azole resistance in Candida auris clinical isolates Open

Sourav Kumar Das, Shreya Singh, Yamini Tawde, Tushar K. Dutta, Shivaprakash M. Rudramurthy , et al. · 2024

Multidrug-resistant yeast Candida auris is a serious threat to public health with documented survival in various hospital niches. The dynamics of this survival benefit and its trade off with drug resistance are still unknown for thi…

Carbon substrates promotes stress resistance and drug tolerance in clinical isolates of Candida tropicalis Open

Arpita Khamrai, Saikat Paul, Shivaprakash M. Rudramurthy, Anup Ghosh · 2024

Candida tropicalis is a human pathogen and one of the most prevalent non-Candida albicans Candida (NCAC) species causing invasive infections. Azole antifungal resistance in C. tropicalis is also gradually increasing with the increasing inc…

The role of bacterial Type VI secretion system (T6SS) in microbial competition in the gut Open

Sunita Gupta, Anup Ghosh, Sujata Das, Amirul Islam Mallick · 2023

India has continuously progressed from domestic poultry farming to the techno-commercial sector to meet the increased consumer preference for quality eggs, meat, and meat products.However, its growing demand is often associated with the in…

Clinical and Mycologic Characteristics of Emerging Mucormycosis Agent Rhizopus homothallicus Open

Shivaprakash M. Rudramurthy, Shreya Singh, Rimjhim Kanaujia, Hansraj Chaudhary, Valliappan Muthu , et al. · 2023

We retrospectively reviewed consecutive cases of mucormycosis reported from a tertiary-care center in India to determine the clinical and mycologic characteristics of emerging Rhizopus homothallicus fungus. The objectives were ascertaining…

Response to comment on: Clinical and mycological profile of fungal keratitis from North and North-East India Open

Yamini Tawde, Shreya Singh, Sourav Das, Shivaprakash M. Rudramurthy, Harsimran Kaur , et al. · 2023

Dear Editor, We are thankful to the authors for their interest in our work entitled "Clinical and mycological profile of fungal keratitis from North and North-East India." We appreciate the thorough reading and thoughtful queries raised by…

How diverse are farming systems on the Eastern Gangetic Plains of South Asia? A multi-metric and multi-country assessment Open

Brendan Brown, Anjana Chaudhary, Akriti Sharma, Pragya Timsina, Emma Karki , et al. · 2023

While crop diversification has many benefits and is a stated government objective across the Eastern Gangetic Plains (EGP) of South Asia, the complexity of assessment has led to a rather limited understanding on the progress towards, and s…

Trend of pediatric cryptococcosis in a tertiary care centre and review of literature Open

Harsimran Kaur, Parakriti Gupta, Rakesh Kumar Pilania, Deepti Suri, Surjit Singh , et al. · 2022

To the best of our knowledge, this is the first clinico-epidemiological study of pediatric cryptococcosis from India and the largest retrospective study worldwide. The rising incidence among immunocompetent individuals, especially in Asia,…

Clinical utility of time to positivity of blood cultures in cases of fungaemia: A prospective study Open

Harsimran Kaur, Rimjhim Kanaujia, Shreya Singh, Kamal Kajal, Muralidharan Jayashree , et al. · 2022

TTP for yeast may provide insight regarding the responsible yeast species before final identification among critical patients with candidaemia. Larger studies are warranted for evaluating clinical utility of TTP considering other complex f…

Evaluation of environmental Mucorales contamination in and around the residence of COVID-19-associated mucormycosis patients Open

Anup Ghosh, Ravinder Singh, Snigdha Reddy, Shreya Singh, Shivaprakash M. Rudramurthy , et al. · 2022

Introduction Recently, India witnessed an unprecedented surge of coronavirus disease 2019 (COVID-19)-associated mucormycosis (CAM) cases. In addition to patient management issues, environmental Mucorales contamination possibly contributed …

P205 Uncommon Aspergillus species encountered in human infections Open

Prakriti Gupta, Harsimran Kaur, Sourav Agnihotri, Anup Ghosh, Shivaprakash M. Rudramurthy · 2022

Poster session 2, September 22, 2022, 12:30 PM - 1:30 PM Objective Aspergillus species are ubiquitously found in environment and have propensity to infect both immunocompromised as well as immunocompetent individuals. Though the most commo…

P017 Echinocandin resistance mechanism in Candida tropicalis and Candida glabrata Open

Dipti Sharma, Raees A. Paul, Jayashree Murlidharan, Sadhna Sharma, Harsimran Kaur , et al. · 2022

Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Objective Candida tropicalis and Candida glabrata account for 41.6% and 7.08% of total Candidaemia cases in India. Echinocandins are the first-line treatment option for these infecti…

P411 Genus specific real-time PCR-a promising technique for rapid diagnosis of fungal keratitis Open

Yamini Tawde, Sourav Kumar Das, Shreya Singh, Savitri Sharma, Amit Gupta , et al. · 2022

Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objective Comparison of different existing molecular methods for diagnosis of fungal keratitis (FK) and to develop and validate genus-specific PCR for identification of most predomin…

P019 A 5-year study on prevalence and molecular determinants of fluconazole -resistance in C. parapsilosis spp. complex Open

Vrinda Sharma, Raees A. Paul, Harsimran Kaur, Sourav Kumar Das, Hansraj Choudhary , et al. · 2022

Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Objectives Candida parapsilosis species complex is among the leading agents of invasive candidiasis, notably in neonates and transplant recipients. It exhibits intrinsically reduced …

P142 Lodderomyces elongisporus: A n emerging cause of fung emia Open

Harsimran Kaur, Parakriti Gupta, Shamanth Shankarnarayan, Abhishek Pandey, Anup Ghosh , et al. · 2022

Poster session 2, September 22, 2022, 12:30 PM - 1:30 PM Background Lodderomyces elongisporus, earlier considered as a sexual state of Candida parapsilosis, was described as a distinct species based on ribosomal RNA gene sequencing. Few ca…

P395 Clinical utility of semi-nested conventional PCR for diagnosis of mucormycosis in fresh clinical samples Open

Hansraj Choudhary, Rimjhim Kanaujia, Shreya Singh, Sourav Agnihotri, Valliappan Muthu , et al. · 2022

Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objectives We aim to assess the clinical utility of the semi-nested conventional PCR in smear positive, culture-negative clinical samples for diagnosis of mucormycosis. Methods This …

P444 Detection of causative agents of infectious keratitis in patients from western rajasthan Open

Twishi Shrimali, Anuradha Sharma, Anup Ghosh, Arvind Kumar Morya, Vibhor Tak , et al. · 2022

Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objective To determine the spectrum of causative agents, the related risk factors, and their association in patients of infectious keratitis. Methodology It was a prospective study c…

P294 A descriptive study of Trichosporon fungemia cases from tertiary care center from north India Open

Priya Srinivasan, Harsimran Kaur, Parakriti Gupta, Abhishek Pandey, Raees A. Paul , et al. · 2022

Poster session 2, September 22, 2022, 12:30 PM - 1:30 PM Objective Incidence of fungaemia with Trichosporon spp is increasing especially in immunocompromised patients. High mortality of 60% is associated with T. fungemia. Trichosporon spec…

S5.1d Mechanisms of azole antifungal resistance in clinical isolates of Candida tropicalis Open

Anup Ghosh, Paul Paul, Dipika Shaw, Himanshu Joshi, Shreya Singh , et al. · 2022

S5.1 Antifungal resistance, September 22, 2022, 3:00 PM - 4:30 PM Objectives In tropical countries, the azole resistance in Candida tropicalis is on the rise. There are limited studies available regarding the azole resistance mechanisms in…

P005 Competitive fitness and trade-offs associated with azole resistance in Candida auris clinical isolates Open

Sourav Kumar Das, Yamini Tawde, Shreya Singh, Arunaloke Chakrabarti, Shivaprakash M. Rudramurthy , et al. · 2022

Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Objectives Following the global emergence of Candida auris, this multidrug-resistant yeast has become a concern of serious threat to public health. The evolution of such multidrug-re…

P394 Evaluation of diagnostic potential of recombinant secretory aspartyl proteinase 2 (Sap2) protein from Candida parapsilosis for use in systemic candidiasis Open

Manisha Shukla, Pankaj Chandley, Harsimran Kaur, Anup Ghosh, Shivaprakash M. Rudramurthy , et al. · 2022

Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objectives Systemic candidiasis is the fourth most common bloodstream infection in ICU patients worldwide. Along with Candida albicans, infections caused by non-albicans Candida (NAC…

P392 Comparative evaluation of Wako β-glucan test and Fungitell assay for the diagnosis of invasive fungal infections Open

Shreya Singh, Sourav Agnihotri, Harsimran Kaur, Rimjhim Kanaujia, Anup Ghosh , et al. · 2022

Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objectives Serum 1,3 β-D-glucan (BDG) has shown wide utility as a broad fungal biomarker for invasive fungal disease (IFD). Fungitell assay (USA) is the only FDA-approved kit availab…

P015 A study to demonstrate heteroresistance and tolerance to azoles in Candida tropicalis Open

Snigdha Reddy, Sourav Kumar Das, Arunaloke Chakrabarti, Shivaprakash M. Rudramurthy, Harsimran Kaur , et al. · 2022

Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Objective Candida tropicalis rarely exhibits a trailing growth phenomenon in in vitro antifungal susceptibility testing (AFST) of azoles. This phenomenon is considered as ‘sensitive’…

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