Ambuj Roy
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View article: Human Stem Cell-Derived Extracellular Vesicles: A Pioneering Path from Biogenesis to Cerebral Ischemic Stroke Therapy
Human Stem Cell-Derived Extracellular Vesicles: A Pioneering Path from Biogenesis to Cerebral Ischemic Stroke Therapy Open
Despite advances in modern medicine and increased public awareness, cerebral stroke remains a leading cause of death and long-term disability worldwide. With over 600,000 new cases annually, innovative therapeutic strategies are being expl…
View article: Comparison of video laryngoscope with direct laryngoscope for endotracheal intubation by cardiology residents: A randomized cross-over manikin-based study
Comparison of video laryngoscope with direct laryngoscope for endotracheal intubation by cardiology residents: A randomized cross-over manikin-based study Open
Background Critically ill cardiac patients may decompensate suddenly owing to arrhythmias and worsening haemodynamics, often necessitating emergent endotracheal intubation. Training in airway management is usually neglected for residents i…
View article: Exercise-based cardiac rehabilitation for coronary heart disease: the CaReMATCH individual participant data meta-analysis
Exercise-based cardiac rehabilitation for coronary heart disease: the CaReMATCH individual participant data meta-analysis Open
Aims The effectiveness of exercise-based cardiac rehabilitation (ExCR) for coronary heart disease (CHD) has been debated during the past decade. The objectives of the Cardiac Rehabilitation Meta-Analysis of Trials in people with CHD using …
View article: Salivary small extracellular vesicles reveal protein signatures in young patients with coronary artery disease
Salivary small extracellular vesicles reveal protein signatures in young patients with coronary artery disease Open
For the first time, we present unique saliva sEVs protein signatures associated with CAD. Validation in larger cohorts may establish Cystatin S as a potential diagnostic biomarker for CAD.
View article: Validation of complete and shortened WHO Rose angina questionnaire to detect coronary heart disease in a tertiary care hospital
Validation of complete and shortened WHO Rose angina questionnaire to detect coronary heart disease in a tertiary care hospital Open
Both RAQ and SRAQ have poor accuracy in diagnosing CHD in the Indian population. Alternate tools are needed for determining the population burden of CHD in India.
View article: Virtual training of trainers for skill acquisition using blended learning. A new experience of an old format: A pilot project
Virtual training of trainers for skill acquisition using blended learning. A new experience of an old format: A pilot project Open
Background Blended learning (BL) for skill acquisition is an integral part of the undergraduate curriculum. Teachers may be trained in BL using physical or virtual platforms. Training of Trainers (ToT) using a virtual platform was adopted …
View article: Comparison of dual therapies for hypertension treatment in India: a randomized clinical trial
Comparison of dual therapies for hypertension treatment in India: a randomized clinical trial Open
Evidence is lacking for guiding optimal combination hypertension therapy in South Asian patients. Here we investigated the blood pressure (BP)-lowering efficacy and safety of three commonly recommended antihypertensive dual combinations in…
View article: Development of an Indian-adapted anti-inflammatory Mediterranean diet for coronary artery disease patients
Development of an Indian-adapted anti-inflammatory Mediterranean diet for coronary artery disease patients Open
The IAMD developed with the lowest DII scores reported has the potential to be cardioprotective. However, this diet plan needs to be tested for acceptability and effectiveness in feasibility studies and clinical trials.
View article: Sudden cardiac death in young: A cardiac-focused autopsy and molecular study to identify the cause
Sudden cardiac death in young: A cardiac-focused autopsy and molecular study to identify the cause Open
Negative autopsy/SUD constituted the most common observation in sudden young deaths, followed by CAD/MI. Molecular autopsy in sudden unexplained deaths in young will give a definitive molecular yield of 14.3 %.
View article: Fluorodeoxyglucose Positron Emission Tomography Detects Persistent Arterial Inflammation After Symptomatic COVID-19
Fluorodeoxyglucose Positron Emission Tomography Detects Persistent Arterial Inflammation After Symptomatic COVID-19 Open
Ongoing arterial inflammation is detected by FDG-PET imaging after mild-to-moderate COVID-19. Larger prospective studies are needed to assess the implications on CVD risk.
View article: Exploring the Nexus among Board Gender Diversity, Women Empowerment, and Social Welfare: Evidence from India
Exploring the Nexus among Board Gender Diversity, Women Empowerment, and Social Welfare: Evidence from India Open
The theory and existing literature suggest multiple advantages of gender diverse boards including active engagement of women directors towards social welfare. Yet, the representation of women directors in the board is not significant. Henc…
View article: Assessing the Influence of Merger with Respect to Financial Performance of Indian Bank: A Camel Approach Analysis
Assessing the Influence of Merger with Respect to Financial Performance of Indian Bank: A Camel Approach Analysis Open
The merger of Allahabad Bank and Indian Bank, effective from April 1, 2020, is a significant event in India’s public sector banking consolidation. This study examines the merger's impact on Indian Bank’s financial performance using the CAM…
View article: Comparison of online content-based training with hands-on mannequin-based skill training on basic life support knowledge and skills among medical students
Comparison of online content-based training with hands-on mannequin-based skill training on basic life support knowledge and skills among medical students Open
BACKGROUND: Sudden cardiac arrest remains a leading global cause of death. High-quality chest compressions during cardiopulmonary resuscitation (CPR) are crucial for patient outcomes. Basic life support (BLS) training must be adequately in…
View article: Influenza vaccine in cardiovascular disease: Current evidence and practice in India
Influenza vaccine in cardiovascular disease: Current evidence and practice in India Open
Influenza is a common trigger for cardiovascular events. Temporal association studies of influenza and cardiovascular events have well documented this phenomenon. More recently, randomised clinical trials of influenza vaccine have shown th…
View article: Treatment optimisation for blood pressure with single-pill combinations in India (TOPSPIN) – Protocol design and baseline characteristics
Treatment optimisation for blood pressure with single-pill combinations in India (TOPSPIN) – Protocol design and baseline characteristics Open
The TOPSPIN trial is the first randomised evaluation of commonly used BP-lowering combination therapies in a South Asian population. The results have potentially significant implications for choosing first-line antihypertensive agents amon…
View article: 9317 Diabetogenic Stress-Mediated Beta Cell Extracellular Vesicle:Autophagy Pathway Crosstalk
9317 Diabetogenic Stress-Mediated Beta Cell Extracellular Vesicle:Autophagy Pathway Crosstalk Open
Disclosure: A. Roy: None. G. Ariyaratne: None. A. Matveyenko: None. N. Javeed: None. Diabetogenic stressors including elevated free fatty acids (lipotoxicity), low-grade systemic inflammation, and proteotoxicity are central to the developm…
View article: Strengthening cardiac services in Faridabad District: A facility mapping exercise to explore implementation of a hub-and-spoke model
Strengthening cardiac services in Faridabad District: A facility mapping exercise to explore implementation of a hub-and-spoke model Open
Background & objectives Improving access to acute cardiac care requires remodelling of existing health systems into a service delivery network with an anchor establishment (Hub) offering a full array of services, complemented by spoke esta…
View article: Role of miR-128-3p and miR-195-5p as biomarkers of coronary artery disease in Indians: a pilot study
Role of miR-128-3p and miR-195-5p as biomarkers of coronary artery disease in Indians: a pilot study Open
Coronary artery disease (CAD) imposes a significant economic burden in developing countries like India. Timely diagnosis and treatment should be prioritized to mitigate the disease. Current diagnostic tools being invasive and less specific…