Anupama Pasam
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View article: Tumors Located in the Brain Impair the Frequency and Phenotype of Dendritic Cells in Blood and Tumor
Tumors Located in the Brain Impair the Frequency and Phenotype of Dendritic Cells in Blood and Tumor Open
Background Professional antigen-presenting dendritic cells (DC) are critical for anti-tumor immune responses, yet patients with glioblastoma, an aggressive primary brain tumor that responds poorly to current investigational immunotherapies…
View article: Detection of PSMA expression on circulating tumor cells by blood-based liquid biopsy in prostate cancer
Detection of PSMA expression on circulating tumor cells by blood-based liquid biopsy in prostate cancer Open
Background: For patients with mCRPC, PSMA-targeted radioligand treatment has significantly improved the clinical outcome. A blood-based liquid biopsy assay for recognizing PSMA protein expression on circulating tumor cells may be beneficia…
View article: Copy number architectures define treatment-mediated selection of lethal prostate cancer clones
Copy number architectures define treatment-mediated selection of lethal prostate cancer clones Open
View article: Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments
Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments Open
Spatial proteomics technologies have revealed an underappreciated link between the location of cells in tissue microenvironments and the underlying biology and clinical features, but there is significant lag in the development of downstrea…
View article: Supplementary Figures 1 - 3 from MEK Inhibition, Alone or in Combination with BRAF Inhibition, Affects Multiple Functions of Isolated Normal Human Lymphocytes and Dendritic Cells
Supplementary Figures 1 - 3 from MEK Inhibition, Alone or in Combination with BRAF Inhibition, Affects Multiple Functions of Isolated Normal Human Lymphocytes and Dendritic Cells Open
PDF file - 376K, Supplementary Figure 1. Representative flow cytometry data of T-cell proliferation. Supplementary Figure 2. Gating strategy for T-lymphocyte cytokine production. Supplementary Figure 3. Gating strategy for antigen specific…
View article: Supplementary Figures 1 - 3 from MEK Inhibition, Alone or in Combination with BRAF Inhibition, Affects Multiple Functions of Isolated Normal Human Lymphocytes and Dendritic Cells
Supplementary Figures 1 - 3 from MEK Inhibition, Alone or in Combination with BRAF Inhibition, Affects Multiple Functions of Isolated Normal Human Lymphocytes and Dendritic Cells Open
PDF file - 376K, Supplementary Figure 1. Representative flow cytometry data of T-cell proliferation. Supplementary Figure 2. Gating strategy for T-lymphocyte cytokine production. Supplementary Figure 3. Gating strategy for antigen specific…
View article: Data from MEK Inhibition, Alone or in Combination with BRAF Inhibition, Affects Multiple Functions of Isolated Normal Human Lymphocytes and Dendritic Cells
Data from MEK Inhibition, Alone or in Combination with BRAF Inhibition, Affects Multiple Functions of Isolated Normal Human Lymphocytes and Dendritic Cells Open
Combination therapy with BRAF and MEK inhibition is currently in clinical development for the treatment of BRAF-mutated malignant melanoma. BRAF inhibitors are associated with enhanced antigen-specific T-lymphocyte recognition in vivo
View article: Supplementary Figure Legends from MEK Inhibition, Alone or in Combination with BRAF Inhibition, Affects Multiple Functions of Isolated Normal Human Lymphocytes and Dendritic Cells
Supplementary Figure Legends from MEK Inhibition, Alone or in Combination with BRAF Inhibition, Affects Multiple Functions of Isolated Normal Human Lymphocytes and Dendritic Cells Open
PDF file - 79K
View article: Data from MEK Inhibition, Alone or in Combination with BRAF Inhibition, Affects Multiple Functions of Isolated Normal Human Lymphocytes and Dendritic Cells
Data from MEK Inhibition, Alone or in Combination with BRAF Inhibition, Affects Multiple Functions of Isolated Normal Human Lymphocytes and Dendritic Cells Open
Combination therapy with BRAF and MEK inhibition is currently in clinical development for the treatment of BRAF-mutated malignant melanoma. BRAF inhibitors are associated with enhanced antigen-specific T-lymphocyte recognition in vivo
View article: Supplementary Figure Legends from MEK Inhibition, Alone or in Combination with BRAF Inhibition, Affects Multiple Functions of Isolated Normal Human Lymphocytes and Dendritic Cells
Supplementary Figure Legends from MEK Inhibition, Alone or in Combination with BRAF Inhibition, Affects Multiple Functions of Isolated Normal Human Lymphocytes and Dendritic Cells Open
PDF file - 79K
View article: Treatment-mediated selection of lethal prostate cancer clones defined by copy number architectures
Treatment-mediated selection of lethal prostate cancer clones defined by copy number architectures Open
Despite initial responses to hormone treatment, metastatic prostate cancer invariably evolves to a lethal state. To characterize the intra-patient relationships of metastases that evade treatment, we performed genome-wide copy number profi…
View article: Treatment-mediated selection of lethal prostate cancer clones defined by copy number architectures
Treatment-mediated selection of lethal prostate cancer clones defined by copy number architectures Open
Despite initial responses to hormone treatment, metastatic prostate cancer invariably evolves to a lethal state. To characterize the intra-patient relationships of metastases that evade treatment, we performed genomewide copy number profil…
View article: Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes
Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes Open
Background Aberrations in homologous recombination repair (HRR) genes are emerging as important biomarkers for personalized treatment in prostate cancer (PCa). HRR deficiency (HRD) could affect the tumor immune microenvironment (TIME), pot…
View article: Ropporin-1 and 1B Are Widely Expressed in Human Melanoma and Evoke Strong Humoral Immune Responses
Ropporin-1 and 1B Are Widely Expressed in Human Melanoma and Evoke Strong Humoral Immune Responses Open
Antibodies that block immune regulatory checkpoints (programmed cell death 1, PD-1 and cytotoxic T-lymphocyte-associated antigen 4, CTLA-4) to mobilise immunity have shown unprecedented clinical efficacy against cancer, demonstrating the i…
View article: Prostate cancer cell‐intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone
Prostate cancer cell‐intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone Open
View article: Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma
Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma Open
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced melanoma. The first ICI to demonstrate clinical benefit, ipilimumab, targets cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4); however, the long-term ove…