Anurag Varshney
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View article: Temporal diversity of phytochemicals in Tinospora cordifolia (Giloy), in accordance with seasonal variations: comparative analysis using UHPLC-PDA and HPTLC
Temporal diversity of phytochemicals in Tinospora cordifolia (Giloy), in accordance with seasonal variations: comparative analysis using UHPLC-PDA and HPTLC Open
View article: Comparative study to assess the outcome of surgical management of humerus shaft fracture: anterior bridge plating versus humerus intramedullary nailing
Comparative study to assess the outcome of surgical management of humerus shaft fracture: anterior bridge plating versus humerus intramedullary nailing Open
Background: Aims and objectives of the study were to assess the outcomes of surgical management of humeral shaft fractures using anterior bridge plating (ABP) versus humeral intramedullary nailing (HIN) in terms of functional recovery and …
View article: Traditional and Complementary Approaches in Combating Central Sensitisation of Pain in Osteoarthritis: Trends and Advances
Traditional and Complementary Approaches in Combating Central Sensitisation of Pain in Osteoarthritis: Trends and Advances Open
Background Osteoarthritis (OA) is a degenerative joint disease increasingly linked to neuroinflammation, and a heightened response of nociceptive neurons called central sensitisation, leading to persistent pain and functional decline. Neur…
View article: Linolenic acid-enriched supercritical carbon dioxide extract from seeds of Phyllanthus emblica L., a functional food with quorum quenching and anti-biofilm action, rescues Caenorhabditis elegans infection model from Pseudomonas aeruginosa
Linolenic acid-enriched supercritical carbon dioxide extract from seeds of Phyllanthus emblica L., a functional food with quorum quenching and anti-biofilm action, rescues Caenorhabditis elegans infection model from Pseudomonas aeruginosa Open
Despite the widespread use of Phyllanthus emblica Linn. (Indian gooseberry) fruit as a nutritional food source, the seeds have been largely overlooked for their nutritive and therapeutic benefits. This study employs a sustainable carbon di…
View article: Essential Oils Enriched Dant-Kanti-Gandush (Oil-pulling) Inhibits Inter-kingdom Biofilm Formation on Orthodontic Fixtures and Ameliorates Cariogenic Virulence Factors of Oral Pathogens
Essential Oils Enriched Dant-Kanti-Gandush (Oil-pulling) Inhibits Inter-kingdom Biofilm Formation on Orthodontic Fixtures and Ameliorates Cariogenic Virulence Factors of Oral Pathogens Open
Orthodontic fixtures provide a conducive niche for microbial colonization and inter-kingdom biofilm formation, exacerbating oral hygiene challenges. Conventional mouthwashes, though effective, are associated with adverse effects and potent…
View article: In-depth chromatographic and spectrally defined phytocompounds in super-critical-CO2 extracted Phyllanthus emblica seeds oil show robust anti-microbial/biofilm effects in the non-mutagenic manner
In-depth chromatographic and spectrally defined phytocompounds in super-critical-CO2 extracted Phyllanthus emblica seeds oil show robust anti-microbial/biofilm effects in the non-mutagenic manner Open
Bioactive-rich plant-based oils are gaining attention for their antimicrobial properties, addressing concerns of antibiotic resistance. Phyllanthus emblica L. known for its medicinal benefits, has been explored for its pharmacological pote…
View article: Integrating gas-chromatographical analyses with nuclear-magnetic-resonance spectroscopy to elucidate anti-microbial profile of oleoresins isolated from Rauvolfia serpentina seeds by supercritical–(CO2)–fluid extraction
Integrating gas-chromatographical analyses with nuclear-magnetic-resonance spectroscopy to elucidate anti-microbial profile of oleoresins isolated from Rauvolfia serpentina seeds by supercritical–(CO2)–fluid extraction Open
Rauvolfia serpentina (L.) Benth. Ex Kurz is a greatly appreciated medicinal plant, well-known for its therapeutic benefits in traditional medicine, particularly in Ayurveda, where the roots and whole plant are used to treat a variety of ai…
View article: Polystyrene microplastic induced airway hyper-responsiveness, and pulmonary inflammation are mitigated by bronchom treatment in murine model of lung disease
Polystyrene microplastic induced airway hyper-responsiveness, and pulmonary inflammation are mitigated by bronchom treatment in murine model of lung disease Open
Microplastics are global menace-associated with respiratory damages. The objective of this study was to investigate the airway hyper-responsiveness (AHR) and inflammation induced by polystyrene microplastic (PSMPs) in male C57BL/6 mice and…
View article: Neurogrit Gold Attenuates 6‐<scp>OHDA</scp>‐Induced Dopaminergic Neurodegeneration in Parkinson's Model of <i>Caenorhabditis elegans</i> by Reducing α‐Synuclein Accumulation and <i>Pink/Pdr‐1</i> Driven Mitochondrial Dysfunction
Neurogrit Gold Attenuates 6‐<span>OHDA</span>‐Induced Dopaminergic Neurodegeneration in Parkinson's Model of <i>Caenorhabditis elegans</i> by Reducing α‐Synuclein Accumulation and <i>Pink/Pdr‐1</i> Driven Mitochondrial Dysfunction Open
Introduction Parkinson's disease (PD) is a neurodegenerative disorder majorly associated with movement and behavioral disturbances. Pathologically, the loss of dopaminergic (DA) neurons triggered by the deposition of α‐synuclein (SNCA) lea…
View article: Anti-Psoriatic Efficacies of Psorogrit and Divya-Taila, in Murine Models of Imiquimod and TPA-Induced Psoriasis-Like Inflammation are Driven by Modulation in IL-17RA/IL-23 and IL-8/TNF-α Signaling Axes
Anti-Psoriatic Efficacies of Psorogrit and Divya-Taila, in Murine Models of Imiquimod and TPA-Induced Psoriasis-Like Inflammation are Driven by Modulation in IL-17RA/IL-23 and IL-8/TNF-α Signaling Axes Open
The combinatorial use of Psorogrit and Divya-Taila has the potential to ameliorate clinical and pathological manifestations of psoriasis.
View article: Anti-furfurative comparison of Kesh Kanti-Herbal Shampoos and synthetic shampoos against Malassezia furfur for dandruff management
Anti-furfurative comparison of Kesh Kanti-Herbal Shampoos and synthetic shampoos against Malassezia furfur for dandruff management Open
View article: Livogrit mitigates ANIT-induced cholestasis-like symptoms in an in vivo model by curbing hepatic inflammation and regulating BAX, TGF-β, MMP-9 and α-SMA gene expression
Livogrit mitigates ANIT-induced cholestasis-like symptoms in an in vivo model by curbing hepatic inflammation and regulating BAX, TGF-β, MMP-9 and α-SMA gene expression Open
Bile duct constriction disrupts bile acid flow causing cholestasis, hepatic necrosis, fibrosis, and cirrhosis. The study investigated hepatoprotective effectiveness of Ayurvedic prescription herbal medicine "Livogrit" commercially availabl…
View article: Herbo‐Mineral Medicine, Cardiogrit Gold, Exhibits Protective Effects in <i>Caenorhabditis elegans</i> Model of Doxorubicin‐Induced Cardiotoxicity
Herbo‐Mineral Medicine, Cardiogrit Gold, Exhibits Protective Effects in <i>Caenorhabditis elegans</i> Model of Doxorubicin‐Induced Cardiotoxicity Open
Doxorubicin, an effective antineoplastic agent, is often prescribed for the treatment of various carcinomas. However, the use of doxorubicin becomes limited due to its adverse effects like cardiotoxicity, dysmenorrhea, and leucopenia. Card…
View article: Herbomineral Medicine Peedanil Gold Exerts Analgesia in Neuropathy by Moderating Inflammatory Response and TRP Channel Expression in Sprague Dawley Rat Surgical Chronic Constriction Injury Model
Herbomineral Medicine Peedanil Gold Exerts Analgesia in Neuropathy by Moderating Inflammatory Response and TRP Channel Expression in Sprague Dawley Rat Surgical Chronic Constriction Injury Model Open
Background: Chronic neuropathic pain, a debilitating health condition, significantly deteriorates the quality of life. Available treatment options, mostly focusing on pain management, do not target underlying cause, resulting in suboptimal…
View article: Coronil effectively inhibits the interaction of clinically relevant Omicron mutants of SARS-CoV-2 spike proteins with human ACE2 receptor
Coronil effectively inhibits the interaction of clinically relevant Omicron mutants of SARS-CoV-2 spike proteins with human ACE2 receptor Open
Background: Accumulating evidence suggests that the receptor binding domain (RBD) of the SARS-CoV-2 Omicron variant has several times more binding affinity to the human angiotensin-converting enzyme 2 (ACE2) receptor compared to the RBD of…
View article: Herbo-vitamin medicine Livogrit Vital ameliorates isoniazid induced liver injury (IILI) in human liver (HepG2) cells by decreasing isoniazid accumulation and oxidative stress driven hepatotoxicity
Herbo-vitamin medicine Livogrit Vital ameliorates isoniazid induced liver injury (IILI) in human liver (HepG2) cells by decreasing isoniazid accumulation and oxidative stress driven hepatotoxicity Open
View article: Correction: Balkrishna et al. Application of Zebrafish Model in the Suppression of Drug-Induced Cardiac Hypertrophy by Traditional Indian Medicine Yogendra Ras. Biomolecules 2020, 10, 600
Correction: Balkrishna et al. Application of Zebrafish Model in the Suppression of Drug-Induced Cardiac Hypertrophy by Traditional Indian Medicine Yogendra Ras. Biomolecules 2020, 10, 600 Open
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View article: Renogrit selectively protects against cisplatin-induced injury in human renal tubular cells and in Caenorhabditis elegans by harmonizing apoptosis and mitophagy
Renogrit selectively protects against cisplatin-induced injury in human renal tubular cells and in Caenorhabditis elegans by harmonizing apoptosis and mitophagy Open
View article: Coronil biochemically inhibits the interaction of various clinically relevant mutants of SARS-CoV-2 Spike Proteins (Omicron Variants) with human ACE2 receptor
Coronil biochemically inhibits the interaction of various clinically relevant mutants of SARS-CoV-2 Spike Proteins (Omicron Variants) with human ACE2 receptor Open
Background Accumulating evidence suggests that the receptor binding domain (RBD) of the SARS-CoV-2 Omicron variant has several times more binding affinity to the human angiotensin-converting enzyme 2 (ACE2) receptor compared to the RBD of …
View article: In mouse model of mixed granulocytic asthma with corticosteroid refractoriness, Bronchom mitigates airway hyperresponsiveness, inflammation and airway remodeling
In mouse model of mixed granulocytic asthma with corticosteroid refractoriness, Bronchom mitigates airway hyperresponsiveness, inflammation and airway remodeling Open
View article: Dissecting the natural phytochemical diversity of carrot roots with its colour using high performance liquid chromatography and UV–Visible spectrophotometry
Dissecting the natural phytochemical diversity of carrot roots with its colour using high performance liquid chromatography and UV–Visible spectrophotometry Open
The research provides insights into the phytoconstituents of black, orange and red carrots (Daucus carota subsp. Sativus (Hoffm.) Schübl. & G. Martens), a highly nutritious food crop widely appreciated across age groups. Recognising…
View article: Fevogrit, a polyherbal medicine, mitigates endotoxin (lipopolysaccharide)‐induced fever in Wistar rats by regulating pro‐inflammatory cytokine levels
Fevogrit, a polyherbal medicine, mitigates endotoxin (lipopolysaccharide)‐induced fever in Wistar rats by regulating pro‐inflammatory cytokine levels Open
Background Fever is characterized by an upregulation of the thermoregulatory set‐point after the body encounters any pathological challenge. It is accompanied by uncomfortable sickness behaviors and may be harmful in patients with other co…
View article: Robust anti-tubercular profile of Solanum virginianum extract in enhancing isoniazid bioavailability and curtailing stress tolerance in Mycobacterium smegmatis
Robust anti-tubercular profile of Solanum virginianum extract in enhancing isoniazid bioavailability and curtailing stress tolerance in Mycobacterium smegmatis Open
Introduction The formidable survival mechanisms employed by Mycobacterium tuberculosis ( Mtb ), combined with the low bioavailability of anti-tubercular drugs and their associated hepatotoxicity, worsen tuberculosis management. Traditional…
View article: UPLC-QTOF-MS characterized, herbal medicine, pancogrit modulates NF-κB and JAK2/STAT3 signaling pathways in cell-based model of TNF-α dependent acute pancreatitis
UPLC-QTOF-MS characterized, herbal medicine, pancogrit modulates NF-κB and JAK2/STAT3 signaling pathways in cell-based model of TNF-α dependent acute pancreatitis Open
Acute pancreatitis develops as a local inflammatory condition of the pancreas due to a wide range of factors including overdose of alcohol or drugs, gall stones, etc. At present, medications based on herbal formulations have gained importa…
View article: Thyrogrit, supplemented with a sub-optimal dose of levothyroxine, restores thyroid function in rat model of propylthiouracil-induced hypothyroidism
Thyrogrit, supplemented with a sub-optimal dose of levothyroxine, restores thyroid function in rat model of propylthiouracil-induced hypothyroidism Open
Background Hypothyroidism is a common endocrine ailment, whose current standard of care is hormonal replacement therapy with levothyroxine (LT4). There is a medical need for alternative and safer therapies as LT4 is associated with special…
View article: Bronchom assuages airway hyperresponsiveness in house dust mite-induced mouse model of allergic asthma and moderates goblet cell metaplasia, sub-epithelial fibrosis along with changes in Th2 cytokines and chemokines
Bronchom assuages airway hyperresponsiveness in house dust mite-induced mouse model of allergic asthma and moderates goblet cell metaplasia, sub-epithelial fibrosis along with changes in Th2 cytokines and chemokines Open
Background Asthma is a common obstructive airway disease with an inflammatory etiology. The main unmet need in the management of asthma is inadequate adherence to pharmacotherapy, leading to a poorly-controlled disease state, necessitating…
View article: Author Correction: Withania somnifera (L.) Dunal whole-plant extract demonstrates acceptable non-clinical safety in rat 28-day subacute toxicity evaluation under GLP-compliance
Author Correction: Withania somnifera (L.) Dunal whole-plant extract demonstrates acceptable non-clinical safety in rat 28-day subacute toxicity evaluation under GLP-compliance Open
View article: Livogrit prevents Amiodarone-induced toxicity in experimental model of human liver (HepG2) cells and <i>Caenorhabditis elegans</i> by regulating redox homeostasis
Livogrit prevents Amiodarone-induced toxicity in experimental model of human liver (HepG2) cells and <i>Caenorhabditis elegans</i> by regulating redox homeostasis Open
Treatment with cationic amphiphilic drugs like Amiodarone leads to development of phospholipidosis, a type of lysosomal storage disorder characterized by excessive deposition of phospholipids. Such disorder in liver enhances accumulation o…
View article: Exploring the potential of Mustard (Brassica spp.) seeds through ‘Kolhu’ traditional method of extraction and novel identification of an anti-cancer dipeptide, Aurantiamide acetate (Asperglaucide) on ultra-performance liquid chromatography-mass spectrometry coupled with quadrupole time-of-flight (UPLC/MS-QToF) analytical platform
Exploring the potential of Mustard (Brassica spp.) seeds through ‘Kolhu’ traditional method of extraction and novel identification of an anti-cancer dipeptide, Aurantiamide acetate (Asperglaucide) on ultra-performance liquid chromatography-mass spectrometry coupled with quadrupole time-of-flight (UPLC/MS-QToF) analytical platform Open
Mustard (Brassica spp.) is one of the world's oldest condiments in the food basket, which holds a significant place in the global culinary landscape due to historical prominence and perceived health benefits. This study explores the extrac…
View article: Herbo-Mineral Medicine, Lithom Exhibits Anti-Nephrolithiasis Activity in Rat Model of Hyperoxaluria by Attenuating Calcium Oxalate Crystal Formation and Oxidative Stress
Herbo-Mineral Medicine, Lithom Exhibits Anti-Nephrolithiasis Activity in Rat Model of Hyperoxaluria by Attenuating Calcium Oxalate Crystal Formation and Oxidative Stress Open
Taken together, Lithom could be a potential clinical-therapeutic alternative for management of nephrolithiasis.