Anusha Shirwaikar Thomas

Validation of the Immune-Mediated Colitis Endoscopic Score using a Retrospective Cohort of Patients with Immune-Mediated Colitis Open

Malek Shatila, Carolina Colli Cruz, Krishnavathana Varatharajalu, Andres Caleb Urias Rivera, Kian Abdul-Baki , et al. · 2025

Recent Abdominal Surgery as a Risk Factor for Unfavorable Immune-Mediated Colitis Outcomes Open

Rohan Ahuja, Malek Shatila, Jay Shah, Cristina Natha, Varun Vemulapalli MDi , et al. · 2025

Surgery within 3 years of IMC diagnosis confers an increased IMC severity with high rates of hospitalization, recurrence, upper gastrointestinal adverse events, and decreased overall survival. Concomitant antibiotic usage serves as an effe…

Upfront fecal microbiota transplantation for the management of immune checkpoint inhibitor mediated diarrhea and colitis Open

Yinghong Wang, Christopher Fan, Krishnavathana Varatharajalu, Malek Shatila, Carolina Uribe Cruz , et al. · 2025

Introduction: Immune checkpoint inhibitors have revolutionized cancer therapy; however, adverse events from an unchecked immune system such as immune checkpoint inhibitor mediated diarrhea and colitis (IMDC) can develop. Fecal microbiota t…

Helicobacter pylori infection negatively affects response of gastric cancer to immunotherapy Open

Malek Shatila, Gabriel Sperling, Antonio Pizuorno Machado, Muhammad S. Vohra, Elliot Baerman , et al. · 2025

These findings suggest H. pylori infection may be an obstacle to successful immunotherapy, and may interact with cancer subtypes to differentially impact survival. Future studies are needed to validate the potential prognostic value…

1485 Randomized clinical trial of infliximab versus vedolizumab for immune checkpoint inhibitor related colitis Open

Yinghong Wang, Krishnavathana Varatharajalu, Malek Shatila, Carolina Colli Cruz, Matthew T. Campbell , et al. · 2024

Magnetic Resonance Imaging Features for Distinguishing High-Grade From Low-Grade Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis Open

Wilhelmina N Hauwanga, Billy McBenedict, Kang Suen Goh, Ryan Chun Chien Yau, Anusha Shirwaikar Thomas , et al. · 2024

Soft tissue sarcomas are malignant tumors characterized by heterogeneity and are associated with a high mortality rate. Histopathological grading is considered a pivotal factor in prognostication and treatment planning. While core needle b…

Approaches in Adult Glioblastoma Treatment: A Systematic Review of Emerging Therapies Open

Billy McBenedict, Wilhelmina N Hauwanga, Anna Pogodina, Gurinder Singh, Anusha Shirwaikar Thomas , et al. · 2024

Outcomes of Different Surgical Interventions for Treating Trigeminal Neuralgia: A Review Open

Billy McBenedict, Wilhelmina N Hauwanga, Melvin Chun Yang Yau, Anna Pogodina, Gurinder Singh , et al. · 2024

Impact of Academic Role on Physical Activity, Health Locus of Control, and Health-Related Quality of Life Open

Kimberly Feiler, Anusha Shirwaikar Thomas · 2024

This research investigated physical activity (PA), health locus of control, and health-related quality of life for adults working and/or enrolled at higher education institutions in California. Roles were full-time or part-time: student, f…

Neuropathic Pain Secondary to Multiple Sclerosis: A Narrative Review Open

Billy McBenedict, Kang Suen Goh, Ryan Chun Chien Yau, Sara Elamin, Walaa H Yusuf , et al. · 2024

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS). Neuropathic pain in MS is a debilitating symptom that significantly impairs the quality of life for a substantial proportion of MS patie…

Guillain-Barre Syndrome and Hemophagocytic Lymphohistiocytosis in a Patient Post-COVID-19 Infection: A Case Report Open

Anusha Shirwaikar Thomas, Aaron Alex Abraham, Abin M Abraham · 2024

The Severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) infection causes a wide range of neurologic and hematologic manifestations. Herein, we report the case of a 69-year-old Indian male with concurrent Guillain-Barre syndrome (G…

Outcomes of Budesonide as a Treatment Option for Immune Checkpoint Inhibitor-Related Colitis in Patients with Cancer Open

Antonio Pizuorno Machado, Abdullah S. Shaikh, Alice Saji, Malek Shatila, Isabella Glitza Oliva , et al. · 2024

Background: Current treatment guidelines for moderate to severe colitis (IMC) secondary to immune checkpoint inhibitors (ICI) recommend systemic corticosteroids as the primary therapy in conjunction with biologics, namely infliximab and/or…

Immune checkpoint inhibitor-associated gastrointestinal adverse events in patients with colorectal cancer Open

Antonio Pizuorno Machado, Malek Shatila, Parvir Aujla, Ryan Huey, Yinghong Wang , et al. · 2024

Purpose: Immune checkpoint inhibitors (ICI) are currently employed for the management of microsatellite instability-high (MSI-H) tumors with success. While immune checkpoint inhibitor related colitis is a very frequent and a devastating im…

A Comprehensive Narrative Review of Neuropathic Pain: From Pathophysiology to Surgical Treatment Open

Bruno Lima Pessôa, Wilhelmina N Hauwanga, Anusha Shirwaikar Thomas, Gabriella Valentim, Billy McBenedict · 2024

Neuropathic pain is a challenging condition. Despite the immense progress made in the pathophysiology and treatment of such conditions, so much work still has to be done. New frontiers previously unexplored are now objects of study with ex…

Temporal Trends of Age-Adjusted Mortality Rates for Rheumatic Heart Disease in Brazil From 2000 to 2021 Open

Billy McBenedict, Zaeemah Mansoor, Abhishek Chaudhary, Anusha Shirwaikar Thomas, Muhammad Yaseen , et al. · 2024

Background Rheumatic heart disease (RHD) is a chronic cardiovascular condition stemming from an infectious origin, posing a substantial health burden, particularly in economically disadvantaged regions. It starts with acute rheumatic fever…

Practice Changes in Checkpoint Inhibitor-Induced Immune-Related Adverse Event Management at a Tertiary Care Center Open

Malek Shatila, Farzin Eshaghi, Austin R. Thomas, Andrew Kuang, Jay S. Shah , et al. · 2024

Understanding of immune-related adverse events (irAEs) has evolved rapidly, and management guidelines are continually updated. We explored temporal changes in checkpoint inhibitor-induced irAE management at a tertiary cancer care center to…

Immune checkpoint inhibitor-associated gastrointestinal adverse events in patients with colorectal cancer Open

Antonio Pizuorno Machado, Saltenat Moghaddam Adames, Malek Shatila, Parvir Aujla, Ryan Huey , et al. · 2024

The lower severity of IMC, compared to toxicity in other ICI-treated cancers, may be influenced by the tumor microenvironment in MSI-H colorectal cancer after ICI exposure. Larger prospective studies are necessary to determine the role of …

Immune Checkpoint Inhibitor-Induced Pancreatic Injury: Clinical and Radiological Profile and Response to Steroids Open

Anusha Shirwaikar Thomas, Michael Abreo, Ahmed Sayed Ahmed, Sai Prasada Rao Manikonda, Mostafa Eyada , et al. · 2023

Pneumatosis intestinalis in cancer patients who received immune checkpoint inhibitors Open

Gabriel Sperling, Malek Shatila, Yang Lü, Mehmet Altan, Yan Zhou , et al. · 2023

Microbiome alteration via fecal microbiota transplantation is effective for refractory immune checkpoint inhibitor–induced colitis Open

Taylor M. Halsey, Anusha Shirwaikar Thomas, Tomo Hayase, Weijie Ma, Hamzah Abu‐Sbeih , et al. · 2023

Immune checkpoint inhibitors (ICIs) target advanced malignancies with high efficacy but also predispose patients to immune-related adverse events like immune-mediated colitis (IMC). Given the association between gut bacteria with response …

Clinical Features and Management of Acute and Chronic Radiation-Induced Colitis and Proctopathy Open

Hamzah Abu‐Sbeih, Tenglong Tang, Faisal S. Ali, Weijie Ma, Malek Shatila , et al. · 2023

Background: RICAP is a recognized adverse effect of radiation therapy (RT) that can adversely affect cancer patients’ quality of life. Data on the clinical characteristics and outcomes of RICAP are scarce. We aimed to analyze the clinical …

Concurrent immune checkpoint inhibition and selective immunosuppressive therapy in patients with immune-related enterocolitis Open

Yousef R. Badran, Fangwen Zou, Sienna Durbin, Barbara E. Dutra, Hamzah Abu‐Sbeih , et al. · 2023

Purpose Immune checkpoint inhibitor (ICI) therapy is often suspended because of immune-related enterocolitis (irEC). We examined the effect of resumption of ICIs with or without concurrent selective immunosuppressive therapy (SIT) on rates…

IL12/23 Blockade for Refractory Immune-Mediated Colitis: 2-Center Experience Open

Anusha Shirwaikar Thomas, Seung Eun Lee, Malek Shatila, Enrico N. De Toni, Helga‐Paula Török , et al. · 2023

INTRODUCTION: Immune checkpoint inhibitor–mediated colitis (IMC) is commonly managed with steroids and biologics. We evaluated the efficacy of ustekinumab (UST) in treating IMC refractory to steroids plus infliximab and/or vedolizumab. RES…

Sclerosing mesenteritis following immune checkpoint inhibitor therapy Open

Andrew Kuang, Gabriel Sperling, Tom Z. Liang, Yang Lü, Dongfeng Tan , et al. · 2023

Obesity Measured via Body Mass Index May Be Associated with Increased Incidence but Not Worse Outcomes of Immune-Mediated Diarrhea and Colitis Open

Miho Kono, Malek Shatila, Guofan Xu, Yang Lu, Antony Mathew , et al. · 2023

Obesity defined by high body mass index (BMI) has traditionally been associated with gastrointestinal inflammatory processes but has recently been correlated with better survival in patients receiving immune checkpoint inhibitors (ICI). We…

Effects of immunosuppressive treatment on patient outcomes after immune checkpoint inhibitor-related gastrointestinal toxicity Open

Malek Shatila, Weijie Ma, Yantong Cui, Sidra Naz, Anusha Shirwaikar Thomas , et al. · 2023

Immune-related adverse events after immune checkpoint inhibitor exposure in adult cancer patients with pre-existing autoimmune diseases Open

Antonio Pizuorno Machado, Malek Shatila, Cynthia Liu, Jianbo Wang, Mehmet Altan , et al. · 2023

Characteristics, treatment, and outcome of patients with bowel perforation after immune checkpoint inhibitor exposure Open

Antonio Pizuorno Machado, Malek Shatila, Cynthia Liu, Yang Lü, Mehmet Altan , et al. · 2023

The Safety of Immunosuppressants Used in the Treatment of Immune-Related Adverse Events due to Immune Checkpoint Inhibitors: a Systematic Review Open

Antonio Pizuorno Machado, Hunter N. Ratliff, Ahmed Abdelwahab, Muhammad H. Vohra, Andrew Kuang , et al. · 2023

Purpose: Immune checkpoint inhibitor (ICI) use can lead to immune-related adverse events (irAEs) that require treatment with immunosuppressive medications in moderate to severe cases. Oncology society guidelines recommend systemic s…

Colon Adenoma After Diagnosis of Immune Checkpoint Inhibitor-mediated Colitis Open

Antonio Pizuorno Machado, Malek Shatila, Enrico N. De Toni, Helga‐Paula Török, Jessica Philpott , et al. · 2023

Purpose: While the occurrence of colitis during immune checkpoint inhibitor (ICI) treatment is recognized as a sign of robust immune activation and correlates with better oncological outcomes, the long-term impact of ICI-mediated co…

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