Anusha Valpadashi
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View article: Silencing mitochondrial gene expression in living cells
Silencing mitochondrial gene expression in living cells Open
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, the central mechanisms underlying mitochondrial gene expres…
View article: Definition of the human mitochondrial TOM interactome reveals TRABD as a new interacting protein
Definition of the human mitochondrial TOM interactome reveals TRABD as a new interacting protein Open
The mitochondrial proteome arises from dual genetic origins. Nuclear-encoded proteins need to be transported across or inserted into two distinguished membranes, and the translocase of the outer mitochondrial membrane (TOM) complex represe…
View article: A microscopy-based screen identifies cellular kinases modulating mitochondrial translation
A microscopy-based screen identifies cellular kinases modulating mitochondrial translation Open
Mitochondrial DNA encodes 13 subunits of the oxidative phosphorylation (OXPHOS) system, which are synthesized inside the organelle and essential for cellular energy supply. How mitochondrial gene expression is regulated and integrated into…
View article: Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria
Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria Open
Cellular proteostasis requires transport of polypeptides across membranes. Although defective transport processes trigger cytosolic rescue and quality control mechanisms that clear translocases and membranes from unproductive cargo, protei…
View article: The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity
The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity Open
View article: The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity
The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity Open
SUMMARY The SARS-CoV-2 genome encodes a multitude of accessory proteins. Using comparative genomic approaches, an additional accessory protein, ORF3c, has been predicted to be encoded within the ORF3a sgmRNA. Expression of ORF3c during inf…
View article: Defining the architecture of the human TIM22 complex by chemical crosslinking
Defining the architecture of the human TIM22 complex by chemical crosslinking Open
The majority of mitochondrial proteins are nuclear encoded and imported into mitochondria as precursor proteins via dedicated translocases. The translocase of the inner membrane 22 (TIM22) is a multisubunit molecular machine specialized fo…
View article: Increased supraorganization of respiratory complexes is a dynamic multistep remodelling in response to proteostasis stress
Increased supraorganization of respiratory complexes is a dynamic multistep remodelling in response to proteostasis stress Open
Proteasome-mediated degradation of misfolded proteins prevents aggregation inside and outside mitochondria. But how do cells safeguard the mitochondrial proteome and mitochondrial functions despite increased aggregation during proteasome i…