Khaled M. Aboshanab
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View article: Correlation between the antibiotic resistance and virulence determinants of vancomycin-resistant enterococci: paradoxical involvement of vanA in phenotypic resistance to teicoplanin
Correlation between the antibiotic resistance and virulence determinants of vancomycin-resistant enterococci: paradoxical involvement of vanA in phenotypic resistance to teicoplanin Open
Background Antimicrobial resistance, particularly in clinical Enterococcus isolates, poses a serious global health threat because of difficult-to-treat nosocomial infections. The emergence of vancomycin-resistant enterococci (VRE), mediate…
View article: Anti-aflatoxigenic effect of Lactobacillus rhamnosus and its synbiotic combination of chitosan/ZnO in milk
Anti-aflatoxigenic effect of Lactobacillus rhamnosus and its synbiotic combination of chitosan/ZnO in milk Open
Aflatoxin contamination of milk is a serious health concern. When animals ingested food contaminated with aflatoxin B1 (AFB1), it would be converted into aflatoxin M1 (AFM1) and secreted in the milk. This carcinogenic and hepatotoxic toxin…
View article: Antibacterial, antibiofilm and cytotoxic activity of synthesized metal-incorporated mesoporous silica nanoparticles
Antibacterial, antibiofilm and cytotoxic activity of synthesized metal-incorporated mesoporous silica nanoparticles Open
Antibiotic misuse has triggered a global health crisis due to the rise of antimicrobial-resistant microorganisms. Recent studies suggest that nanoparticles (NPs), particularly silver nanoparticles, may provide a solution. However, their to…
View article: Recent insights on challenges encountered with phage therapy against gastrointestinal-associated infections
Recent insights on challenges encountered with phage therapy against gastrointestinal-associated infections Open
Gastrointestinal (GI) infections, caused by pathogens such as Escherichia coli, Salmonella sp., Shigella sp., and Clostridium difficile, pose significant global health challenges due to their prevalence, severity, and increasing resistance…
View article: Genomic characterization and pre-clinical evaluation of a new polyvalent lytic Loughborough phage
Genomic characterization and pre-clinical evaluation of a new polyvalent lytic Loughborough phage Open
Carbapenem-resistant Acinetobacter baumannii (CRAB) has become a critical concern that necessitates the development of novel antimicrobial approaches. One of the most promising innovative approaches for combating CRAB infections is using e…
View article: Anticancer, antimicrobial and molecular docking analysis of newly synthesized iodoquinazoline derivatives
Anticancer, antimicrobial and molecular docking analysis of newly synthesized iodoquinazoline derivatives Open
The 4-anilinoquinazoline sulfonamide derivatives in medicinal chemistry are well-known antitumor backbones via different mechanisms. Herein, we reported the synthesis of five new 2,4-disubstituted-6-iodoquinazoline derivatives coded compou…
View article: D-optimal design model and biosynthetic pathway for gentamicin production by Micromonospora purpureochromogenes NRRL B-16094
D-optimal design model and biosynthetic pathway for gentamicin production by Micromonospora purpureochromogenes NRRL B-16094 Open
Background Micromonospora purpureochromogenes NRRL B-16094, a natural producer of gentamicin (GEN), a 5,6-diglycosylated 2-dexoystreptamine-aminoglycoside antibiotic (2DOS-AGA) broad-spectrum bactericidal activity. In literature, limited s…
View article: In vitro and preclinical evaluation of the antifungal activity of 6-methoxy-1 H-indole-2-carboxylic acid produced by Bacillus toyonensis strain OQ071612 formulated as nanosponge hydrogel
In vitro and preclinical evaluation of the antifungal activity of 6-methoxy-1 H-indole-2-carboxylic acid produced by Bacillus toyonensis strain OQ071612 formulated as nanosponge hydrogel Open
Background In a previous study, 6-methoxy-1 H-indole-2-carboxylic acid (MICA) was isolated from the culture broth of Bacillus toyonensis strain OQ071612 soil isolate in our laboratory, and it demonstrated promising antifungal activities. T…
View article: Role of CRISPR-Cas system as a new approach in fighting the antimicrobial resistance of bacterial and viral pathogens
Role of CRISPR-Cas system as a new approach in fighting the antimicrobial resistance of bacterial and viral pathogens Open
The clustered regularly interspaced short palindromic repeat (CRISPR)-Caspase (Cas) system acts as a natural defense of bacteria against invasion by mobile genetic elements, such as plasmids, transposons, and bacteriophages. The review dis…
View article: Biologically active metabolites of <i>Alcaligenes faecalis:</i> diversity, statistical optimization, and future perspectives
Biologically active metabolites of <i>Alcaligenes faecalis:</i> diversity, statistical optimization, and future perspectives Open
Alcaligenes faecalis is a Gram-negative, rod-shaped bacterium that is common in the environment and has been reported to have various bioactive metabolites of industrial potential applications, including antifungal, antibacterial, antimyco…
View article: Combinatorial biosynthesis of novel aminoglycoside antibiotics via pathway engineering
Combinatorial biosynthesis of novel aminoglycoside antibiotics via pathway engineering Open
With the current spread of clinically relevant multidrug-resistant (MDR) pathogens, insufficient unearthing of new anti-infectives, and the high cost required for approval of new antimicrobial agents, a strong need for getting these agents…
View article: Monitoring the VDPV2 outbreak in Egypt during 2020–2021 highlights the crucial role of environmental surveillance and boosting immunization in combating Poliovirus
Monitoring the VDPV2 outbreak in Egypt during 2020–2021 highlights the crucial role of environmental surveillance and boosting immunization in combating Poliovirus Open
Background Poliovirus is a highly infectious enterovirus (EV) that primarily affects children and can lead to lifelong paralysis or even death. Vaccine-derived polioviruses (VDPVs) are a great threat since they are derived from the attenua…
View article: Hematological, inflammatory and serological responses among COVID-19 patients admitted to intensive care unit
Hematological, inflammatory and serological responses among COVID-19 patients admitted to intensive care unit Open
Aim: To correlate hematological, inflammatory indicators and serological responses among COVID-19 patients to point out the significant biomarkers for disease management and prognosis.Materials & methods: Standard analytical and molecular …
View article: Multi-epitope peptide vaccines targeting dengue virus serotype 2 created via immunoinformatic analysis
Multi-epitope peptide vaccines targeting dengue virus serotype 2 created via immunoinformatic analysis Open
The Middle East has witnessed a greater spread of infectious Dengue viruses, with serotype 2 (DENV-2) being the most prevalent form. Through this work, multi-epitope peptide vaccines against DENV-2 that target E and nonstructural (NS1) pro…
View article: Effectiveness of Pre-Transplant Screening for High-Priority Multidrug-Resistant Pathogens on Pre-Engraftment Infections After Hematopoietic Stem Cell Transplantation
Effectiveness of Pre-Transplant Screening for High-Priority Multidrug-Resistant Pathogens on Pre-Engraftment Infections After Hematopoietic Stem Cell Transplantation Open
Active screening cultures are a helpful tool for identifying patients colonized by MDRO or relevant viruses before HSCT, and for predicting those at risk of developing subsequent pre-engraftment infections. Additionally, active screening m…
View article: Benchmarking long-read aligners and SV callers for structural variation detection in Oxford nanopore sequencing data
Benchmarking long-read aligners and SV callers for structural variation detection in Oxford nanopore sequencing data Open
Structural variants (SVs) are one of the significant types of DNA mutations and are typically defined as larger-than-50-bp genomic alterations that include insertions, deletions, duplications, inversions, and translocations. These modifica…