Anwen E. Brown
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View article: A drug repurposing screen for whipworms informed by comparative genomics
A drug repurposing screen for whipworms informed by comparative genomics Open
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura . Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs appr…
View article: A drug repurposing screen for whipworms informed by comparative genomics
A drug repurposing screen for whipworms informed by comparative genomics Open
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura . Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs appr…
View article: 2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm
2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm Open
The human whipworm Trichuris trichiura is a parasite that infects around 500 million people globally, with consequences including damage to physical growth and educational performance. Current drugs such as mebendazole have a notable lack …
View article: 2,4-Diaminothieno[3,2-<i>d</i>]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm
2,4-Diaminothieno[3,2-<i>d</i>]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm Open
The human whipworm Trichuris trichiura is a parasite that infects around 500 million people globally, with consequences including damage to physical growth and educational performance. Current drugs such as mebendazole have a notable lack …
View article: An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes
An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes Open
Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of therapeutic compounds is limited and parasite resistance to the existing anthel…
View article: An automated high-throughput system for phenotypic screening of chemical libraries on<i>C. elegans</i>and parasitic nematodes
An automated high-throughput system for phenotypic screening of chemical libraries on<i>C. elegans</i>and parasitic nematodes Open
Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of therapeutic compounds is limited and parasite resistance to the existing anthel…