Anyirékun Fabrice Somé
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View article: Neonatal mortality in The Gambia and Burkina Faso: insights to incidence and risk factors from clinical trial data
Neonatal mortality in The Gambia and Burkina Faso: insights to incidence and risk factors from clinical trial data Open
Introduction Neonatal mortality remains unacceptably high globally, particularly in Sub Saharan Africa. We evaluated the incidence and risk factors for neonatal mortality in The Gambia and Burkina Faso to provide context specific evidence …
View article: Low Birth Weight Neonates in The Gambia & Burkina Faso: Prevalence, risk factors, and short-term adverse outcomes from a prospective observational study utilising trial data
Low Birth Weight Neonates in The Gambia & Burkina Faso: Prevalence, risk factors, and short-term adverse outcomes from a prospective observational study utilising trial data Open
Introduction Approximately 20 million neonates are born with low birth weight (LBW) annually, with West Africa bearing the highest burden of LBW and associated poor outcomes. This study aims to estimate the prevalence of LBW, identify mate…
View article: Clinical epidemiology of intrapartum stillbirths in The Gambia and Burkina Faso: Descriptive cohort analysis from PregnAnZI-2 clinical trial
Clinical epidemiology of intrapartum stillbirths in The Gambia and Burkina Faso: Descriptive cohort analysis from PregnAnZI-2 clinical trial Open
Introduction West Africa has the highest intrapartum stillbirth rate globally, yet there is limited understanding of regional clinical and epidemiological risk factors. Local data on intrapartum stillbirth rates and risk factors is urgentl…
View article: Clinical epidemiology of twin deliveries in The Gambia and Burkina Faso: Secondary analyses of PregnAnZI-2 clinical trial data
Clinical epidemiology of twin deliveries in The Gambia and Burkina Faso: Secondary analyses of PregnAnZI-2 clinical trial data Open
Introduction Twins have higher risk of adverse clinical outcomes in all settings, but especially in low- and middle-income countries. This study aims to understand the clinical epidemiology of twins from varied West African settings, focus…
View article: Determinants of delayed antenatal visit attendance in rural Burkina Faso: a cross-sectional study
Determinants of delayed antenatal visit attendance in rural Burkina Faso: a cross-sectional study Open
Introduction The World Health Organization recommends a minimum of eight antenatal care (ANC) contacts, with the first visit occurring before the 12 th week of gestation, as a strategy to enhance the preparedness of women for institutional…
View article: An electronic clinical support algorithm integrating the Integrated Management of Childhood Illness with malaria and bacterial point-of-care diagnostics to improve outpatient care of febrile children in malaria-endemic settings: e-IMCI+
An electronic clinical support algorithm integrating the Integrated Management of Childhood Illness with malaria and bacterial point-of-care diagnostics to improve outpatient care of febrile children in malaria-endemic settings: e-IMCI+ Open
Background In sub-Saharan Africa, health systems face challenges in reducing the burden of infectious diseases due to the limited availability of qualified human resources in remote areas. Digital clinical decision support implemented to a…
View article: Pixel intensity of wing photos used to infer efficacy of mosquito control interventions against Anopheles gambiae caught during the RIMDAMAL II clinical trial
Pixel intensity of wing photos used to infer efficacy of mosquito control interventions against Anopheles gambiae caught during the RIMDAMAL II clinical trial Open
Mosquito age-grading is important for evaluating mosquito control efforts and estimating pathogen transmission risk. We previously developed a simple, low-cost, and high-throughput method to age-grade mosquitoes by computing the pixel inte…
View article: Effect of pharmacokinetically-relevant ivermectin concentrations on survivorship and fecundity of <i>Anopheles coluzzii</i> and <i>Aedes aegypti</i> in Burkina Faso: a laboratory experimental study
Effect of pharmacokinetically-relevant ivermectin concentrations on survivorship and fecundity of <i>Anopheles coluzzii</i> and <i>Aedes aegypti</i> in Burkina Faso: a laboratory experimental study Open
Background The control of vector-borne diseases is increasingly challenged by widespread insecticide resistance. Therefore, innovative vector control strategies with alternative modes of action are urgently needed. Ivermectin (IVM), an end…
View article: Selection of a Lead Long-Acting Formulation of Ivermectin to Target Major Malaria Vectors in Western Africa: Evaluation of Pharmacokinetics and Mosquitocidal Efficacy in Cattle under Laboratory Conditions.
Selection of a Lead Long-Acting Formulation of Ivermectin to Target Major Malaria Vectors in Western Africa: Evaluation of Pharmacokinetics and Mosquitocidal Efficacy in Cattle under Laboratory Conditions. Open
Background Ivermectin, a semisynthetic endectocide from the avermectin family, has been used in mass drug administration (MDA) campaigns since the 1980s to control helminth infections. Its lethality to Anopheles mosquitoes after feeding on…
View article: Comparative susceptibility of wild and laboratory-reared Aedes and Anopheles larvae to ivermectin
Comparative susceptibility of wild and laboratory-reared Aedes and Anopheles larvae to ivermectin Open
View article: Reproduction number estimation using smoothing methods Reproduction number and smoothing methods
Reproduction number estimation using smoothing methods Reproduction number and smoothing methods Open
The reproduction number for an epidemic is crucial as it helps to understand the potential spread of an infectious disease within a population. It is often estimated through case counting and contact tracing methods. Here, we propose an al…
View article: 95 Assessing genetic diversity of the Pfs25 vaccine candidate: Implications for malaria transmission-blocking vaccine in Africa
95 Assessing genetic diversity of the Pfs25 vaccine candidate: Implications for malaria transmission-blocking vaccine in Africa Open
Objectives/Goals: Transmission-blocking vaccines hold promise for malaria elimination by reducing community transmission. But a major challenge that limits the development of efficacious vaccines is the vast parasite’s genetic diversity. T…
View article: Pixel intensity of wing photos used to predict age of <i>Anopheles gambiae</i> caught during the RIMDAMAL II clinical trial
Pixel intensity of wing photos used to predict age of <i>Anopheles gambiae</i> caught during the RIMDAMAL II clinical trial Open
Mosquito age-grading is important for evaluating mosquito control efforts and estimating pathogen transmission risk. We previously developed a simple, low-cost, and high-throughput method to age-grade mosquitoes by computing the pixel inte…
View article: P-1852. Investigating the infant gut microbiome in relation to R21/Matrix-M™ vaccine immunogenicity and efficacy
P-1852. Investigating the infant gut microbiome in relation to R21/Matrix-M™ vaccine immunogenicity and efficacy Open
Background R21/Matrix-M™ malaria vaccine was recently licensed in young children following good vaccine efficacy and induction of high titre antibody responses to the central repeat (NANP) of the P. falciparum circumsporozoite protein. Var…
View article: Traditional Uses of Seven Medicinal Plants for Malaria Treatment in Bobo-Dioulasso, Burkina Faso
Traditional Uses of Seven Medicinal Plants for Malaria Treatment in Bobo-Dioulasso, Burkina Faso Open
View article: Traffic-Related Air Pollution and Childhood Acute Leukemia in France: Geocap Nationwide Case-Control Study
Traffic-Related Air Pollution and Childhood Acute Leukemia in France: Geocap Nationwide Case-Control Study Open
View article: Additional costs of healthcare-associated infections (HAI) in three hospitals in the City of Bobo Dioulasso, Burkina Faso, 2022: A nested cohort case-control study
Additional costs of healthcare-associated infections (HAI) in three hospitals in the City of Bobo Dioulasso, Burkina Faso, 2022: A nested cohort case-control study Open
View article: Safety and efficacy of the blood-stage malaria vaccine RH5.1/Matrix-M in Burkina Faso: interim results of a double-blind, randomised, controlled, phase 2b trial in children
Safety and efficacy of the blood-stage malaria vaccine RH5.1/Matrix-M in Burkina Faso: interim results of a double-blind, randomised, controlled, phase 2b trial in children Open
The European and Developing Countries Clinical Trials Partnership, the UK Medical Research Council, the National Institute for Health and Care Research Oxford Biomedical Research Centre, the Division of Intramural Research, National Instit…
View article: Comparative susceptibility of wild and laboratory-reared Aedes and Anopheles larvae to Ivermectin®
Comparative susceptibility of wild and laboratory-reared Aedes and Anopheles larvae to Ivermectin® Open
Background Administering ivermectin to humans and livestock renders their blood toxic for mosquitoes like Anopheles and Aedes, offering a promising approach for controlling these vectors. However, the impact of such treatment on larval sta…
View article: Safety and efficacy of the blood-stage malaria vaccine RH5.1/Matrix-M in Burkina Faso: interim results of a double-blind, randomised, controlled phase 2b trial in children
Safety and efficacy of the blood-stage malaria vaccine RH5.1/Matrix-M in Burkina Faso: interim results of a double-blind, randomised, controlled phase 2b trial in children Open
Background Two pre-erythrocytic vaccines (R21/Matrix-M and RTS,S/AS01) are now approved for P. falciparum malaria. However, neither induces blood-stage immunity against parasites that breakthrough from the liver. RH5.1/Matrix-M, a blood-st…
View article: Changing species dynamics and species-specific associations observed between <i>Anopheles</i> and <i>Plasmodium</i> genera in Diebougou health district, southwest Burkina Faso
Changing species dynamics and species-specific associations observed between <i>Anopheles</i> and <i>Plasmodium</i> genera in Diebougou health district, southwest Burkina Faso Open
The prevalence of malaria parasite species in parts of Africa is rapidly changing and influenced by detection methods. The natural vector competence and vectorial capacity of African anophelines for human Plasmodium species has only been w…
View article: Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial
Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial Open
View article: Implementation of the WHO core components of an infection prevention and control programme in two sub-saharan African acute health-care facilities: a mixed methods study
Implementation of the WHO core components of an infection prevention and control programme in two sub-saharan African acute health-care facilities: a mixed methods study Open
View article: Traditional Healer&#8217;s Medicinal Practice Survey and Clinical Evidence Assessment of &#8220;YIKI&#8221;: An Antimalarial Phytomedicine Recipe from Bobo-Dioulasso, Burkina Faso
Traditional Healer’s Medicinal Practice Survey and Clinical Evidence Assessment of “YIKI”: An Antimalarial Phytomedicine Recipe from Bobo-Dioulasso, Burkina Faso Open
YIKI is an antimalarial phytomedicine used by a traditional healer to treat malaria in Bobo-Dioulasso. However, there is no scientific evidence to support its use by local populations. The aim of this study was to identify the medicinal pr…
View article: Repeat Ivermectin Mass Drug Administrations for Malaria Control II (RIMDAMAL II): Primary Outcome from the Cluster-Randomized Control Trial
Repeat Ivermectin Mass Drug Administrations for Malaria Control II (RIMDAMAL II): Primary Outcome from the Cluster-Randomized Control Trial Open
View article: PA-55 Two-step malaria RDT detection PfHRP2/pLDH and point-of-care tests for bacterial infections for the management of febrile diseases in children under-5 years in Burkina Faso
PA-55 Two-step malaria RDT detection PfHRP2/pLDH and point-of-care tests for bacterial infections for the management of febrile diseases in children under-5 years in Burkina Faso Open
Background In low and middle incomes countries such as sub-Saharan Africa, the management of febrile diseases remains challenging given the lack of practical diagnostic tools to screen the real cause of fever and the limits of malaria rapi…
View article: PA-730 Impact of additional screening using highly-sensitive rapid diagnostic tests and treatment combined with monthly Sulfadoxine-Pyrimethamine on LBW and peripheral malaria infection: asser malaria study
PA-730 Impact of additional screening using highly-sensitive rapid diagnostic tests and treatment combined with monthly Sulfadoxine-Pyrimethamine on LBW and peripheral malaria infection: asser malaria study Open
Background The burden of MiP remains high with adverse effects on the health of both women and their offspring. In endemic areas, pregnant women are generally asymptomatic with low parasitemia which can be missed by malaria RDTs, but affec…
View article: Role of Seasonal Importation and Random Genetic Drift on Selection for Drug-Resistant Genotypes of<i>Plasmodium falciparum</i>in High Transmission Settings
Role of Seasonal Importation and Random Genetic Drift on Selection for Drug-Resistant Genotypes of<i>Plasmodium falciparum</i>in High Transmission Settings Open
Historically Plasmodium falciparum has followed a pattern of drug resistance first appearing in low transmission settings before spreading to high transmission settings. Several features of low-transmission regions are hypothesized as expl…
View article: Tracking antimalarial drug resistance using mosquito blood meals: a cross-sectional study
Tracking antimalarial drug resistance using mosquito blood meals: a cross-sectional study Open
For the French translation of the abstract see Supplementary Materials section.
View article: Ivermectin as a Novel Malaria Control Tool: Getting Ahead of the Resistance Curse
Ivermectin as a Novel Malaria Control Tool: Getting Ahead of the Resistance Curse Open
Reduction in malaria clinical cases is strongly dependent on the ability to prevent Anopheles infectious bites. Vector control strategies using long-lasting insecticidal nets and indoor residual spraying with insecticides have con…