Anzy Miller
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View article: Domain-specific mechanisms of YAP1 variants in ocular coloboma revealed by in-vitro and organoid studies
Domain-specific mechanisms of YAP1 variants in ocular coloboma revealed by in-vitro and organoid studies Open
The conserved transcriptional co-activator YAP1 is a central regulator of organ development and tissue homeostasis, integrating mechanical and biochemical cues to control cell proliferation and survival. YAP1 variants underlie a spectrum o…
View article: Pathway to Independence: a forecast for the future of developmental biology
Pathway to Independence: a forecast for the future of developmental biology Open
In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third cohort of eight talented PI fellows. In this artic…
View article: NGN3 oscillatory expression controls the timing of human pancreatic endocrine differentiation
NGN3 oscillatory expression controls the timing of human pancreatic endocrine differentiation Open
Understanding protein expression dynamics is crucial for the mechanistic understanding of cell differentiation. We investigate the dynamics and decoding of NEUROGENIN3 (NGN3), a transcription factor critical for pancreatic endocrine develo…
View article: Oscillatory Co-expression of HES1 and HES5 Enables a Hybrid State in a Bistable Transcription Factor Regulatory Motif
Oscillatory Co-expression of HES1 and HES5 Enables a Hybrid State in a Bistable Transcription Factor Regulatory Motif Open
Many cell fate decisions in the developing neural tube are directed by cross-repressive transcription factor (TF) motifs that generate bistability, enforcing expression of one dominant TF. However, evidence of hybrid states, where cells co…
View article: NGN3 oscillatory expression controls the timing of human pancreatic endocrine differentiation
NGN3 oscillatory expression controls the timing of human pancreatic endocrine differentiation Open
Summary Understanding protein expression dynamics is crucial for the mechanistic understanding of cell differentiation. We investigate the dynamics of NGN3, a transcription factor critical for pancreatic endocrine development, including th…
View article: NGN3 Oscillatory Expression Controls the Timing of Human Pancreatic Endocrine Differentiation
NGN3 Oscillatory Expression Controls the Timing of Human Pancreatic Endocrine Differentiation Open
View article: HES1 protein oscillations are necessary for neural stem cells to exit from quiescence
HES1 protein oscillations are necessary for neural stem cells to exit from quiescence Open
View article: Chromatin Remodelling Proteins and Cell Fate Decisions in Mammalian Preimplantation Development
Chromatin Remodelling Proteins and Cell Fate Decisions in Mammalian Preimplantation Development Open
View article: Transcriptional control by Sall4 in blastocysts facilitates lineage commitment of inner cell mass cells
Transcriptional control by Sall4 in blastocysts facilitates lineage commitment of inner cell mass cells Open
The enhancer-binding zinc finger transcription factor Sall4 is essential for early mammalian postimplantation development and plays important roles in lineage commitment of embryonic stem cells. Enhancer binding by Sall4 results in transcr…
View article: Sall4 controls differentiation of pluripotent cells independently of the Nucleosome Remodelling and Deacetylation (NuRD) complex
Sall4 controls differentiation of pluripotent cells independently of the Nucleosome Remodelling and Deacetylation (NuRD) complex Open
Sall4 is an essential transcription factor for early mammalian development and is frequently overexpressed in cancer. Though it is reported to play an important role in embryonic stem cell self-renewal, whether it is an essential pluripote…