Aoife G. Cotter
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View article: People living with <scp>HIV</scp> on modern antiretrovirals do not display a pro‐atherogenic lipid profile and have similar body composition compared to healthy controls
People living with <span>HIV</span> on modern antiretrovirals do not display a pro‐atherogenic lipid profile and have similar body composition compared to healthy controls Open
Objectives Alterations in lipids and apolipoproteins contribute to cardiovascular disease (CVD) and are common in people with HIV. The aim of our study was to compare lipid profiles and body composition between people with and without HIV …
View article: Healthcare Access for Transgender Women in Malaysia: A Narrative Review of Barriers and Enabling Factors
Healthcare Access for Transgender Women in Malaysia: A Narrative Review of Barriers and Enabling Factors Open
Malaysia is an upper-middle-income country and one of the few in Asia that has achieved Universal Health Coverage (UHC). Despite this, healthcare in Malaysia is less accessible to marginalized groups, such as transgender women, because a l…
View article: GD09 Spotted fever after safari: a case of African tick bite fever highlighting the value of eschar swabs for the molecular detection of rickettsial disease
GD09 Spotted fever after safari: a case of African tick bite fever highlighting the value of eschar swabs for the molecular detection of rickettsial disease Open
African tick bite fever (ATBF) is an emerging rickettsial disease of the spotted fever group increasingly seen in international travellers returning from sub-Saharan Africa. It is caused by Rickettsia africae, an intracellular Gram-negativ…
View article: Longitudinal SARS-CoV-2 antibody response in a healthcare worker cohort utilising the Abbott Alinity® anti-nucleocapsid assay
Longitudinal SARS-CoV-2 antibody response in a healthcare worker cohort utilising the Abbott Alinity® anti-nucleocapsid assay Open
Introduction Healthcare workers (HCWs) in Ireland bore a particularly high burden of SARS-CoV-2 infections, representing over 30% of infections during initial waves. We describe the prevalence, incidence and persistence of SARS-CoV-2 anti-…
View article: Specific thresholds of circulating antibody titers predict against infection and reduced disease severity in SARS-CoV-2 close contacts
Specific thresholds of circulating antibody titers predict against infection and reduced disease severity in SARS-CoV-2 close contacts Open
Higher circulating SARS-CoV-2 IgG titers correlate with SARS-CoV-2 ex vivo viral neutralization, but how well this translates to clinical protection in the real-world setting is unclear. In a prospective cohort study, we enrolled 44 SARS-C…
View article: <i>Ms Radiance</i> : a community-led social media mHealth pilot for transgender women
<i>Ms Radiance</i> : a community-led social media mHealth pilot for transgender women Open
View article: Associations between type III interferons, obesity and clinical severity of COVID-19
Associations between type III interferons, obesity and clinical severity of COVID-19 Open
Introduction Severe COVID-19 is characterized by hyperimmune host responses contributing to airway damage and acute respiratory distress syndrome. Type III interferons (IFN), including IFN lambda 4 (IFNλ4), expressed in individuals harbori…
View article: Exploring the barriers and enablers of oral health care utilisation and safe oral sex practices among transgender women in Malaysia: a qualitative study
Exploring the barriers and enablers of oral health care utilisation and safe oral sex practices among transgender women in Malaysia: a qualitative study Open
Background Transgender women in Malaysia face social and healthcare marginalisation. Research about their oral health and oral health care utilisation is sparse. Despite growing clinical evidence highlighting the risk of transmission of se…
View article: Community involvement and engagement in designing a social-media based educational intervention for oral and sexual health promotion in transgender women in Malaysia: a narrative summary
Community involvement and engagement in designing a social-media based educational intervention for oral and sexual health promotion in transgender women in Malaysia: a narrative summary Open
Patient and public involvement and engagement (PPIE) in health care research has been advocated to ensure that the research is relevant, acceptable and beneficial to the communities that it serves. However, there remains a significant gap …
View article: Development and validation of a quantitative Orthopoxvirus immunoassay to evaluate and differentiate serological responses to Mpox infection and vaccination
Development and validation of a quantitative Orthopoxvirus immunoassay to evaluate and differentiate serological responses to Mpox infection and vaccination Open
Health Research Board (MONKEYVAX-2022-1), University College Dublin School of Medicine.
View article: Associations Between the Gut Microbiome, Inflammation, and Cardiovascular Profiles in People With Human Immunodeficiency Virus
Associations Between the Gut Microbiome, Inflammation, and Cardiovascular Profiles in People With Human Immunodeficiency Virus Open
Background Inflammation and innate immune activation are associated with chronic human immunodeficiency virus (HIV) infection, despite effective treatment. Although gut microbiota alterations are linked to systemic inflammation, their rela…
View article: Clinical Characterization and Outcomes of Human Clade IIb Mpox Virus Disease: A European Multicenter Mpox Observational Cohort Study (MOSAIC)
Clinical Characterization and Outcomes of Human Clade IIb Mpox Virus Disease: A European Multicenter Mpox Observational Cohort Study (MOSAIC) Open
Background The global mpox outbreak that started in May 2022 was caused by a novel clade IIb variant of the mpox virus (Orthopoxvirus monkeypox, MPXV). It differed from the traditional Western and Central Africa disease in transmission pat…
View article: HIV, the gut microbiome and clinical outcomes, a systematic review
HIV, the gut microbiome and clinical outcomes, a systematic review Open
Background Effective antiretroviral therapy (ART) has improved the life expectancy of people with HIV (PWH). However, this population is now experiencing accelerated age‐related comorbidities, contributed to by chronic immune activation an…
View article: Design and development of Ms Radiance: a culturally sensitive, tailor made bilingual educational initiative utilizing Instagram® for transgender women in Malaysia
Design and development of Ms Radiance: a culturally sensitive, tailor made bilingual educational initiative utilizing Instagram® for transgender women in Malaysia Open
Background: Transgender women in Malaysia are marginalized and face barriers in accessing health care. Low oral health care utilization along with gaps in knowledge and perceived low risk of transmission of STIs through oral sexual practic…
View article: Robust and persistent B-cell responses following SARS-CoV-2 vaccine determine protection from SARS-CoV-2 infection
Robust and persistent B-cell responses following SARS-CoV-2 vaccine determine protection from SARS-CoV-2 infection Open
Introduction A clear immune correlate of protection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has not been defined. We explored antibody, B-cell, and T-cell responses to the third-dose vaccine and relation…
View article: Early inflammatory profiles predict maximal disease severity in COVID-19: An unsupervised cluster analysis
Early inflammatory profiles predict maximal disease severity in COVID-19: An unsupervised cluster analysis Open
Early inflammatory profiles predicted subsequent maximal disease severity independent of risk factors for severe COVID-19. A cluster with downregulation of growth factors and endothelial activation markers, and early evidence of alveolar e…
View article: Exploring the barriers and enablers of oral health care utilization and safe oral sex behaviour among Transgender women of Malaysia: a qualitative study
Exploring the barriers and enablers of oral health care utilization and safe oral sex behaviour among Transgender women of Malaysia: a qualitative study Open
Background Transgender women in Malaysia are vulnerable and marginalized. They experience unique social and interpersonal challenges that contribute to relatively unmet health care needs thereby increasing their risk of acquiring HIV and s…
View article: Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus
Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus Open
Despite inflammation being implicated in cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype coul…
View article: Robust and Persistent B Cell Responses Following Third-Dose SARS-CoV-2 Vaccine Determine Protection from SARS-CoV-2 Infection
Robust and Persistent B Cell Responses Following Third-Dose SARS-CoV-2 Vaccine Determine Protection from SARS-CoV-2 Infection Open
View article: Development of a novel medium throughput flow-cytometry based micro-neutralisation test for SARS-CoV-2 with applications in clinical vaccine trials and antibody screening
Development of a novel medium throughput flow-cytometry based micro-neutralisation test for SARS-CoV-2 with applications in clinical vaccine trials and antibody screening Open
Quantifying neutralising capacity of circulating SARS-COV-2 antibodies is critical in evaluating protective humoral immune responses generated post-infection/post-vaccination. Here we describe a novel medium-throughput flow cytometry-based…
View article: 1346. Genetic Variation at the Interferon λ Locus and Association with Clinical Outcome and Severity of COVID-19
1346. Genetic Variation at the Interferon λ Locus and Association with Clinical Outcome and Severity of COVID-19 Open
Background People with obesity are at increased risk of severe COVID-19, with host inflammation a key contributor. Interferon (IFN) lambda 4 (IFNλ4) is a type III IFN expressed in individuals with the rs368234815-ΔG single nucleotide polym…
View article: 2069. Exploring the Barriers and Enablers of Safe Oral Sexual Practices among Transgender Women of Malaysia: A Qualitative Study on STI Transmission
2069. Exploring the Barriers and Enablers of Safe Oral Sexual Practices among Transgender Women of Malaysia: A Qualitative Study on STI Transmission Open
Background Transgender women (TGW) in Malaysia experience unique social and interpersonal challenges that contribute to their risk of acquiring HIV and sexually transmitted infections (STIs). (Fig 1)The study aimed to understand the experi…
View article: 2356. Close correlation of RBD with Live Viral Neutralising Capacity Across Variants and Time Supports Use of RBD Thresholds to Predict Protective Host Immunity
2356. Close correlation of RBD with Live Viral Neutralising Capacity Across Variants and Time Supports Use of RBD Thresholds to Predict Protective Host Immunity Open
Background Although SARS-CoV-2 neutralising antibodies protect against severe COVID-19, whether circulating IgG titres reflect underlying host capacity to neutralise wild type (WT) and variants of concern (VOC) and what IgG threshold refle…
View article: 2338. Robust and Persistent B Cell Responses Following Third Dose SARS-CoV-2 Vaccine Determine Protection from COVID-19
2338. Robust and Persistent B Cell Responses Following Third Dose SARS-CoV-2 Vaccine Determine Protection from COVID-19 Open
Background The immunological memory to SARS-CoV-2 (SCV-2) vaccination has multiple components, with robust antibody (Ab) and B cell responses demonstrated post vaccination. The extent and persistence of T cell responses to vaccination rema…
View article: Impact of vaccination and variants of concern on long COVID clinical phenotypes
Impact of vaccination and variants of concern on long COVID clinical phenotypes Open
View article: Associations between host microbiome and inflammation suggest role for host microbiome in driving COVID-19 disease severity
Associations between host microbiome and inflammation suggest role for host microbiome in driving COVID-19 disease severity Open
Systemic inflammation and innate immune activation are associated with COVID-19 disease severity. Knowledge gaps remain in the relationships between microbiome, inflammation and COVID-19 disease severity. To better characterise these assoc…
View article: Distinct receptor binding domain IgG thresholds predict protective host immunity across SARS-CoV-2 variants and time
Distinct receptor binding domain IgG thresholds predict protective host immunity across SARS-CoV-2 variants and time Open
View article: Post-COVID care delivery: The experience from an Irish tertiary centre’s post-COVID clinic
Post-COVID care delivery: The experience from an Irish tertiary centre’s post-COVID clinic Open
Background The long-term effects of SARS-CoV-2 infection and optimal follow-up approach are not well-recognised. Here we describe the implementation of a post-COVID clinic in an Irish tertiary centre after the first wave of the pandemic. T…
View article: Dysregulated early transcriptional signatures linked to mast cell and interferon responses are implicated in COVID-19 severity
Dysregulated early transcriptional signatures linked to mast cell and interferon responses are implicated in COVID-19 severity Open
Background Dysregulated immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are thought to underlie the progression of coronavirus disease 2019 (COVID-19) to severe disease. We sought to determine whe…
View article: Development of a Novel Medium Throughput Flow-Cytometry Based Micro-Neutralisation Test for SARS-CoV-2 with Applications in Clinical Vaccine Trials and Antibody Screening
Development of a Novel Medium Throughput Flow-Cytometry Based Micro-Neutralisation Test for SARS-CoV-2 with Applications in Clinical Vaccine Trials and Antibody Screening Open
Quantifying neutralising capacity of circulating SARS-COV-2 antibodies is critical in evaluating protective humoral immune responses generated post-infection/post-vaccination. Here we describe a novel medium-throughput flow cytometry-based…