Aoxing Liu
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View article: Dato: A Task-Based Programming Model for Dataflow Accelerators
Dato: A Task-Based Programming Model for Dataflow Accelerators Open
Recent deep learning workloads increasingly push computational demand beyond what current memory systems can sustain, with many kernels stalling on data movement rather than computation. While modern dataflow accelerators incorporate on-ch…
View article: Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes
Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes Open
Clonal hematopoiesis (CH) becomes more prevalent with aging and may influence inflammatory diseases by altering immune function. While CH of indeterminate potential (CHIP) promotes inflammation in nonmalignant conditions, its relationship …
View article: Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms
Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms Open
Type 1 diabetes (T1D) and other autoimmune diseases (AIDs) often co-occur in families. Leveraging data from 58,284 family trios in Finnish nationwide registers (FinRegistry), we identified that, of 50 parental AIDs examined, 15 were associ…
View article: Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity
Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity Open
View article: Prevalence and disease risks for male and female sex chromosome trisomies: a registry-based phenome-wide association study in 1.5 million participants of MVP, FinnGen, and UK Biobank
Prevalence and disease risks for male and female sex chromosome trisomies: a registry-based phenome-wide association study in 1.5 million participants of MVP, FinnGen, and UK Biobank Open
Sex chromosome trisomies (SCT) are the most common whole chromosome aneuploidy in humans. Yet, our understanding of the prevalence and associated health outcomes is largely driven by observational studies of clinically diagnosed cases, res…
View article: Author Correction: Genetic drivers and cellular selection of female mosaic X chromosome loss
Author Correction: Genetic drivers and cellular selection of female mosaic X chromosome loss Open
View article: Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes
Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes Open
Clonal hematopoiesis (CH) becomes more prevalent with age and may impact the pathophysiology of inflammatory diseases by altering immune cell function. While clonal hematopoiesis of indeterminate potential (CHIP) can promote inflammation i…
View article: Transcriptome- and proteome-wide association studies identify genes associated with renal cell carcinoma
Transcriptome- and proteome-wide association studies identify genes associated with renal cell carcinoma Open
View article: Deep learning-based prediction of one-year mortality in Finland is an accurate but unfair aging marker
Deep learning-based prediction of one-year mortality in Finland is an accurate but unfair aging marker Open
View article: Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms
Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms Open
SUMMARY Type 1 diabetes (T1D) and other autoimmune diseases (AIDs) often co-occur in families. Leveraging data from 58,284 family trios in Finnish nationwide registers (FinRegistry), we identified that, out of 50 parental AIDs examined, 15…
View article: Prevalence, Morbidity, and Mortality of Men With Sex Chromosome Aneuploidy in the Million Veteran Program Cohort
Prevalence, Morbidity, and Mortality of Men With Sex Chromosome Aneuploidy in the Million Veteran Program Cohort Open
Importance The reported phenotypes of men with 47,XXY and 47,XYY syndromes include tall stature, multisystem comorbidities, and poor health-related quality of life (HRQOL). However, knowledge about these sex chromosome aneuploidy (SCA) con…
View article: The Impact of the Post-Pandemic Business Environment on Students’ Entrepreneurship
The Impact of the Post-Pandemic Business Environment on Students’ Entrepreneurship Open
View article: Evidence from Finland and Sweden on the relationship between early-life diseases and lifetime childlessness in men and women
Evidence from Finland and Sweden on the relationship between early-life diseases and lifetime childlessness in men and women Open
View article: MA14.05 Tumor Tissue and Plasma EGFR Exon 20 Insertion Mutation Status in NSCLC Patients Treated with Sunvozertinib
MA14.05 Tumor Tissue and Plasma EGFR Exon 20 Insertion Mutation Status in NSCLC Patients Treated with Sunvozertinib Open
View article: Risk factors for severe respiratory syncytial virus infection during the first year of life: development and validation of a clinical prediction model
Risk factors for severe respiratory syncytial virus infection during the first year of life: development and validation of a clinical prediction model Open
Sigrid Jusélius Foundation, European Research Council, Pediatric Research Foundation, and Academy of Finland.
View article: 300 Cell models and a high-throughput assay for discovering novel therapeutics to cure cystic fibrosis
300 Cell models and a high-throughput assay for discovering novel therapeutics to cure cystic fibrosis Open
View article: Deep learning-based prediction of one-year mortality in the entire Finnish population is an accurate but unfair digital marker of aging
Deep learning-based prediction of one-year mortality in the entire Finnish population is an accurate but unfair digital marker of aging Open
Background Accurately predicting short-term mortality is important for optimizing healthcare resource allocation, developing risk-reducing interventions, and improving end-of-life care. Moreover, short-term mortality risk reflects individu…
View article: A FinnGen pilot clinical recall study for Alzheimer’s disease
A FinnGen pilot clinical recall study for Alzheimer’s disease Open
Successful development of novel therapies requires that clinical trials are conducted in patient cohorts with the highest benefit-to-risk ratio. Population-based biobanks with comprehensive health and genetic data from large numbers of ind…
View article: Prevalence, Morbidity, and Mortality of 1,609 Men with Sex Chromosome Aneuploidy: Results from the Diverse Million Veteran Program Cohort
Prevalence, Morbidity, and Mortality of 1,609 Men with Sex Chromosome Aneuploidy: Results from the Diverse Million Veteran Program Cohort Open
STRUCTURED ABSTRACT Importance The reported phenotypes of men with 47,XXY and 47,XYY syndromes include tall stature, multisystem comorbidities, and poor health-related quality of life (HRQoL). However, knowledge about these sex chromosome …
View article: Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry)
Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry) Open
View article: Risk factors for severe respiratory syncytial virus infection during the first year of life: development and validation of a clinical prediction model
Risk factors for severe respiratory syncytial virus infection during the first year of life: development and validation of a clinical prediction model Open
Background Novel immunisation methods against respiratory syncytial virus (RSV) are emerging, but knowledge of risk factors for severe RSV disease is insufficient for their optimal targeting. We aimed to identify predictors for RSV hospita…
View article: Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population
Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population Open
View article: Population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection
Population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection Open
Mosaic loss of the X chromosome (mLOX) is the most commonly occurring clonal somatic alteration detected in the leukocytes of women, yet little is known about its genetic determinants or phenotypic consequences. To address this, we estimat…
View article: Genetic Polymorphism and mRNA Expression Studies Reveal IL6R and LEPR Gene Associations with Reproductive Traits in Chinese Holsteins
Genetic Polymorphism and mRNA Expression Studies Reveal IL6R and LEPR Gene Associations with Reproductive Traits in Chinese Holsteins Open
Genetic selection of milk yield traits alters the energy distribution of high producing cows, resulting in gene-induced negative energy balance, and consequently, poor body condition scores and reduced reproductive performances. Here, we i…
View article: FinnGen provides genetic insights from a well-phenotyped isolated population
FinnGen provides genetic insights from a well-phenotyped isolated population Open
View article: Genetic parameters for dairy calf and replacement heifer wellness traits and their association with cow longevity and health indicators in Holstein cattle
Genetic parameters for dairy calf and replacement heifer wellness traits and their association with cow longevity and health indicators in Holstein cattle Open
High mortality and involuntary culling rates cause great economic losses to the worldwide dairy cattle industry. However, there is low emphasis on wellness traits in replacement animals (dairy calves and replacement heifers) during their d…
View article: A Post-GWAS Functional Analysis Confirming Effects of Three BTA13 Genes CACNB2, SLC39A12, and ZEB1 on Dairy Cattle Reproduction
A Post-GWAS Functional Analysis Confirming Effects of Three BTA13 Genes CACNB2, SLC39A12, and ZEB1 on Dairy Cattle Reproduction Open
In our previous GWAS of Chinese and Nordic dairy cattle, genes CACNB2 , SLC39A12, and ZEB1 locating on BTA 13 were suggested as candidate genes for reproduction. In this study, validation of these associations was performed in an independe…
View article: The relationship of major diseases with childlessness: a sibling matched case-control and population register study in Finland and Sweden
The relationship of major diseases with childlessness: a sibling matched case-control and population register study in Finland and Sweden Open
Summary Background Approximately 20% of men and 15% of women remain childless at the end of their reproductive lifespan, with childlessness increasing over time, yet we lack a comprehensive understanding of the role and relative importance…
View article: FinnGen: Unique genetic insights from combining isolated population and national health register data
FinnGen: Unique genetic insights from combining isolated population and national health register data Open
Population isolates such as Finland provide benefits in genetic studies because the allelic spectrum of damaging alleles in any gene is often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%), wh…
View article: Acupuncture for the Treatment of Knee Osteoarthritis: An Overview of Systematic Reviews
Acupuncture for the Treatment of Knee Osteoarthritis: An Overview of Systematic Reviews Open
Jixin Chen,1,2,* Aifeng Liu,1,2,* Qinxin Zhou,1,2 Weijie Yu,1,2 Tianci Guo,1,2 Yizhen Jia,1,2 Kun Yang,1,2 Puyu Niu,1,2 Huichuan Feng1,2 1Department of Orthopaedic Surgery, First Teaching Hospital of Tianjin University of Traditional Chine…