Aili Fan
YOU?
Author Swipe
View article: Manipulating terahertz phonon-polariton in the ultrastrong coupling regime with bound states in the continuum
Manipulating terahertz phonon-polariton in the ultrastrong coupling regime with bound states in the continuum Open
The strong coupling between photons and phonons in polar materials gives rise to phonon-polaritons that encapsulate a wealth of physical information, offering crucial tools for the ultrafast terahertz sources and the topological engineerin…
View article: Tea tree oil attenuates diquat-induced intestinal barrier dysfunction in chickens via modulating oxidative stress and gut microbiota
Tea tree oil attenuates diquat-induced intestinal barrier dysfunction in chickens via modulating oxidative stress and gut microbiota Open
This study investigated the effects of tea tree oil (TTO) protective effects against diquat (DIQ)-induced toxicity in chickens. 240 one-day-old Hy-Line W-36 laying chickens randomly allocated to one of two treatment groups: 1) chickens fed…
View article: f-BGM enables fungi-specific genome mining in high accuracy and interpretability
f-BGM enables fungi-specific genome mining in high accuracy and interpretability Open
Emerging artificial intelligence (AI)-based genome mining methods have revolutionized the paradigm of bacterial secondary metabolite (SM) discovery. Fortunately, recent data accumulation of fungal biosynthetic gene clusters (BGC) fairly of…
View article: Marine-derived new peptaibols with antibacterial activities by targeting bacterial membrane phospholipids
Marine-derived new peptaibols with antibacterial activities by targeting bacterial membrane phospholipids Open
Antibiotic resistance is spreading at a faster rate than new antibiotic agents applied for clinical remedies. It is an urgent need to discover potential compounds to combat multidrug-resistant (MDR) bacteria. Marine fungi offer a promising…
View article: Manipulating terahertz phonon-polariton in the ultrastrong coupling regime with bound states in the continuum
Manipulating terahertz phonon-polariton in the ultrastrong coupling regime with bound states in the continuum Open
The strong coupling between photons and phonons in polar materials gives rise to phonon-polaritons that encapsulate a wealth of physical information, offering crucial tools for the ultrafast terahertz sources and the topological engineerin…
View article: A global atlas of fungal biosynthetic gene clusters reveals the diversification of diketopiperazine biosynthesis
A global atlas of fungal biosynthetic gene clusters reveals the diversification of diketopiperazine biosynthesis Open
Background Fungi represent one of the largest and most promising reservoirs of structurally diverse natural products. However, the global biosynthetic potential of fungi significantly expanded but remains underexplored. Results Here, we pr…
View article: Mining the Biosynthetic Landscape of Lactic Acid Bacteria Unearths a New Family of RiPPs Assembled by a Novel Type of ThiF-like Adenylyltransferases
Mining the Biosynthetic Landscape of Lactic Acid Bacteria Unearths a New Family of RiPPs Assembled by a Novel Type of ThiF-like Adenylyltransferases Open
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are chemically diverse natural products of ribosomal origin. These peptides, which frequently act as signals or antimicrobials, are biosynthesized by conserved enzy…
View article: Mining the biosynthetic landscape of lactic acid bacteria unearths a new family of RiPPs assembled by a novel type of ThiF-like adenylyltransferases
Mining the biosynthetic landscape of lactic acid bacteria unearths a new family of RiPPs assembled by a novel type of ThiF-like adenylyltransferases Open
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are chemically diverse natural products of ribosomal origin. These peptides, which frequently act as signals or antimicrobials, are biosynthesized by conserved enzy…
View article: Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus Spiromastix sp.
Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus Spiromastix sp. Open
Eleven new brominated depsidones, namely spiromastixones U-Z5 (1–11) along with five known analogues (12–16), were isolated from a deep-sea-derived fungus Spiromastix sp. through the addition of sodium bromide during fermentation. Their st…
View article: Three-dimensional structural alignment based discovery and molecular basis of AtoB, catalyzing linear tetracyclic formation
Three-dimensional structural alignment based discovery and molecular basis of AtoB, catalyzing linear tetracyclic formation Open
Enzymes from the nuclear transport factor 2-like (NTF2-like) superfamily represent a rare group of biocatalysts with diverse catalytic functions facilitating intriguing skeleton formations.
View article: Acorane sesquiterpenes from the deep-sea derived Penicillium bilaiae fungus with anti-neuroinflammatory effects
Acorane sesquiterpenes from the deep-sea derived Penicillium bilaiae fungus with anti-neuroinflammatory effects Open
Acorane-type sesquiterpenes comprise a unique class of natural products with a range of pharmaceutical effects. Genome sequencing and gene annotation, along with qRT-PCR detection, demonstrate that the deep-sea derived Penicillium bilaiae …
View article: Eremophilane-Type Sesquiterpenes from a Marine-Derived Fungus Penicillium Copticola with Antitumor and Neuroprotective Activities
Eremophilane-Type Sesquiterpenes from a Marine-Derived Fungus Penicillium Copticola with Antitumor and Neuroprotective Activities Open
Chemical examination of a marine sponge-associated Penicillium copticola fungus resulted in the isolation of ten undescribed eremophilanes, namely copteremophilanes A–J (1–10), along with two new glycosides, 5-glycopenostatin F (11) and 5-…
View article: CCDC 2110671: Experimental Crystal Structure Determination
CCDC 2110671: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2110637: Experimental Crystal Structure Determination
CCDC 2110637: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2110636: Experimental Crystal Structure Determination
CCDC 2110636: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2110638: Experimental Crystal Structure Determination
CCDC 2110638: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Discovery of cyclohexadepsipeptides with anti-Zika virus activities and biosynthesis of the nonproteinogenic building block (3S)-methyl-l-proline
Discovery of cyclohexadepsipeptides with anti-Zika virus activities and biosynthesis of the nonproteinogenic building block (3S)-methyl-l-proline Open
The fungal cyclohexadepsipeptides destruxins (DTXs), isaridins (ISDs), and isariins (ISRs) are nonribosomal peptides whose structures include a 19-membered ring composed of five amino acid residues and one α- or β-hydroxy acid residue. The…
View article: Chlorinated metabolites with antibacterial activities from a deep-sea-derived <i>Spiromastix</i> fungus
Chlorinated metabolites with antibacterial activities from a deep-sea-derived <i>Spiromastix</i> fungus Open
Chromatographic separation of the solid cultures of a deep-sea-derived Spiromastix fungus (MCCC 3A00308) resulted in the isolation of five chlorinated compounds with antibacterial activities.
View article: Retrospective cohort analysis of heart rate variability in patients with high altitude pulmonary hypertension in <scp>Tibet</scp>
Retrospective cohort analysis of heart rate variability in patients with high altitude pulmonary hypertension in <span>Tibet</span> Open
Background Studies from both humans and animals experiments have offered abundant evidence supporting that mountain sickness is associated with changes in autonomic nervous function (ANF), which can be measured by heart rate variability (H…
View article: Asperphenamate biosynthesis reveals a novel two-module NRPS system to synthesize amino acid esters in fungi
Asperphenamate biosynthesis reveals a novel two-module NRPS system to synthesize amino acid esters in fungi Open
Characterisation of asperphenamate biosynthetic pathway in Penicillium brevicompactum reveals a novel two modular NRPS system for the formation of amino acid esters in nature.
View article: A cryptic pigment biosynthetic pathway uncovered by heterologous expression is essential for conidial development in <i>Pestalotiopsis fici</i>
A cryptic pigment biosynthetic pathway uncovered by heterologous expression is essential for conidial development in <i>Pestalotiopsis fici</i> Open
Summary Spore pigmentation is very common in the fungal kingdom. The best studied pigment in fungi is melanin which coats the surface of single cell spores. What and how pigments function in a fungal species with multiple cell conidia is p…
View article: Biochemische Untersuchungen an bakteriellen und pilzlichen Prenyltransferasen
Biochemische Untersuchungen an bakteriellen und pilzlichen Prenyltransferasen Open
Prenylated natural products are widely distributed in nature and demonstratean amazing varietyof structures and promising biological activities, which are usually distinct from their non-prenylated precursors. Therefore, they are intensive…
View article: Tryptophan prenyltransferases showing higher catalytic activities for Friedel–Crafts alkylation of o- and m-tyrosines than tyrosine prenyltransferases
Tryptophan prenyltransferases showing higher catalytic activities for Friedel–Crafts alkylation of o- and m-tyrosines than tyrosine prenyltransferases Open
Better conversion of l-o- and l-m-tyrosine to their C-prenylated derivatives by tryptophan prenyltransferases (Trp-PTs) than tyrosine O-prenyltransferases (Tyr-O-PT).