Aparna Ramachandran
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View article: Reframing spontaneous preterm birth as a preventable adverse outcome—A clinical audit of a preventative toolbox
Reframing spontaneous preterm birth as a preventable adverse outcome—A clinical audit of a preventative toolbox Open
Introduction Spontaneous preterm birth is a major cause of perinatal morbidity and mortality and has traditionally been viewed as an inevitable event affecting a small proportion of pregnancies. Clinical practice guidelines recommend measu…
View article: First stereoselective approach for structure revision of nagiol and syntheses of 2,3-dihydroxyferruginol and ferruginol
First stereoselective approach for structure revision of nagiol and syntheses of 2,3-dihydroxyferruginol and ferruginol Open
First stereoselective total synthesis and structural revision of (+)-nagiol, and syntheses of (+)-ferruginol and 2,3-dihydroxyferruginol have been reported from podocarpatriene-3-ol.
View article: Changing Indications for Cervical Cerclage Following the Introduction of Routine Ultrasound Surveillance of Cervical Length for Prediction and Prevention of Preterm Birth
Changing Indications for Cervical Cerclage Following the Introduction of Routine Ultrasound Surveillance of Cervical Length for Prediction and Prevention of Preterm Birth Open
Universal cervical length screening results in an increase in the use of cerclage, specifically on the basis of the ultrasound findings. Women who were at low risk but then underwent ultrasound-indicated cerclage experienced most prolongat…
View article: Prediction and prevention of preterm birth: Quality assessment and systematic review of clinical practice guidelines using the AGREE <scp>II</scp> framework
Prediction and prevention of preterm birth: Quality assessment and systematic review of clinical practice guidelines using the AGREE <span>II</span> framework Open
Background Prediction of pregnancies at risk of preterm birth (PTB) may allow targeted prevention strategies. Objectives To assess quality of clinical practice guidelines (CPGs) and identify areas of agreement and contention in prediction …
View article: A neuropathological perspective on fetal holocarboxylase synthetase deficiency
A neuropathological perspective on fetal holocarboxylase synthetase deficiency Open
View article: Sensory processing abilities and their impact on disease severity in children with attention-deficit hyperactivity disorder
Sensory processing abilities and their impact on disease severity in children with attention-deficit hyperactivity disorder Open
Objectives: Although several studies have shown sensory processing abnormalities in pediatric subjects with attention-deficit hyperactivity disorder (ADHD), there is significant heterogeneity among their results. Materials and Methods: Thi…
View article: A <scp>physiologically‐based</scp> pharmacokinetic model for tuberculosis drug disposition at extrapulmonary sites
A <span>physiologically‐based</span> pharmacokinetic model for tuberculosis drug disposition at extrapulmonary sites Open
Tuberculosis (TB) is a leading cause of mortality attributed to an infectious agent. TB primarily targets the lungs, but in about 16% cases can affect other organs as well, giving rise to extrapulmonary TB (EPTB). However, an optimal regim…
View article: Development and Validation of an Outpatient Clinical Predictive Score for the Diagnosis of Duchenne Muscular Dystrophy/Becker Muscular Dystrophy in Children Aged 2–18 Years
Development and Validation of an Outpatient Clinical Predictive Score for the Diagnosis of Duchenne Muscular Dystrophy/Becker Muscular Dystrophy in Children Aged 2–18 Years Open
Introduction: There is no bedside clinical examination-based prediction score for Duchenne muscular dystrophy/Becker muscular dystrophy (DMD/BMD) in children with neuromuscular diseases (NMDs) presenting with proximal limb-girdle weakness.…
View article: Efficacy of a pre-specified timeline-based treatment protocol in children with acute repetitive seizures or seizure clusters
Efficacy of a pre-specified timeline-based treatment protocol in children with acute repetitive seizures or seizure clusters Open
Objectives: Acute repetitive seizures (ARSs) are one of the few commonly encountered neurological emergencies in children. There is a need for an appropriate timeline-based treatment protocol, which will be shown to be safe and efficacious…
View article: A Physiologically-Based Pharmacokinetic Model for Tuberculosis Drug Disposition at Extrapulmonary Sites
A Physiologically-Based Pharmacokinetic Model for Tuberculosis Drug Disposition at Extrapulmonary Sites Open
Tuberculosis (TB) is a leading cause of mortality due to an infectious agent. TB primarily targets the lungs but in about 16% cases can affect other organs as well, giving rise to extrapulmonary TB (EPTB). However, an optimal regimen for E…
View article: Cost-effectiveness of adrenocorticotropic hormone injection and oral prednisolone in patients with West syndrome: A comparative analysis
Cost-effectiveness of adrenocorticotropic hormone injection and oral prednisolone in patients with West syndrome: A comparative analysis Open
Objectives: This study aims to compare the cost-effectiveness of oral prednisolone and adrenocorticotropic hormone injection in West syndrome patients, the two most common hormonal therapies used for this condition. Materials and Methods: …
View article: Effectiveness of prophylactic iron supplementation in the reduction of recurrence of febrile seizures in children: A prospective study with comparison with historical controls
Effectiveness of prophylactic iron supplementation in the reduction of recurrence of febrile seizures in children: A prospective study with comparison with historical controls Open
Objectives: The primary objective of the study was to compare the number of patients with febrile seizure recurrence within 1 year of presenting to our institute, among patients who received and didn’t receive oral iron supplementation. Ma…
View article: Anti-GAD65 Related Neurological Disorder Presenting as Isolated Hemiataxia
Anti-GAD65 Related Neurological Disorder Presenting as Isolated Hemiataxia Open
View article: Safety and Efficacy of Vinpocetine as a Neuroprotective Agent in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis
Safety and Efficacy of Vinpocetine as a Neuroprotective Agent in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis Open
View article: Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase
Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase Open
Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD+ and NADH, using NAD+ and NADH as non-canonical initiating nucleotides fo…
View article: Author response: Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase
Author response: Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase Open
View article: Mitochondrial RNA capping: highly efficient 5’-RNA capping with NAD<sup>+</sup> and NADH by yeast and human mitochondrial RNA polymerase
Mitochondrial RNA capping: highly efficient 5’-RNA capping with NAD<sup>+</sup> and NADH by yeast and human mitochondrial RNA polymerase Open
Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD + and NADH, using NAD + and NADH as non-canonical initiating nucleotides …
View article: Nanotechnology: A promising approach of antiviral treatments against chikungunya virus (CHIKV)
Nanotechnology: A promising approach of antiviral treatments against chikungunya virus (CHIKV) Open
Following its emergence in Africa, spread to the Indian Ocean islands in 2006, and occurrences in regions of the world where it hadn’t been reported in the past, Chikungunya has become an emerging public health concern in many countries. T…
View article: Saliva as A Diagnostic Tool for Detection of the Viruses: A Review
Saliva as A Diagnostic Tool for Detection of the Viruses: A Review Open
Over the last few years, salivary diagnostics has become a topic of discussion for many researchers primarily due to several advantages that offer over other diagnostic methods. Diagnostic techniques that involve oral fluids are mainly of …
View article: Transcriptional fidelities of human mitochondrial POLRMT, yeast mitochondrial Rpo41, and phage T7 single-subunit RNA polymerases
Transcriptional fidelities of human mitochondrial POLRMT, yeast mitochondrial Rpo41, and phage T7 single-subunit RNA polymerases Open
Single-subunit RNA polymerases (RNAPs) are present in phage T7 and in mitochondria of all eukaryotes. This RNAP class plays important roles in biotechnology and cellular energy production, but we know little about its fidelity and error ra…
View article: Human mitochondrial transcription factors TFAM and TFB2M work synergistically in promoter melting during transcription initiation
Human mitochondrial transcription factors TFAM and TFB2M work synergistically in promoter melting during transcription initiation Open
Human mitochondrial DNA is transcribed by POLRMT with the help of two initiation factors, TFAM and TFB2M. The current model postulates that the role of TFAM is to recruit POLRMT and TFB2M to melt the promoter. However, we show that TFAM ha…