Ahmad Reza Bahrami
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View article: Enhancing Anticancer Effects: Targeted Doxorubicin Delivery Using UiO-66-NH2-FA Metal-Organic Framework Combined with Autophagy Inhibition by Hydroxychloroquine in Colorectal Cancer Cells
Enhancing Anticancer Effects: Targeted Doxorubicin Delivery Using UiO-66-NH2-FA Metal-Organic Framework Combined with Autophagy Inhibition by Hydroxychloroquine in Colorectal Cancer Cells Open
View article: Tensor-based morphometry findings corresponding to the novel serum p-tau 217 biomarkers levels in the Alzheimer’s dementia continuum
Tensor-based morphometry findings corresponding to the novel serum p-tau 217 biomarkers levels in the Alzheimer’s dementia continuum Open
Background: Blood, CSF, and imaging biomarkers significantly broaden the global scope of AD diagnosis. The initial changes in all the plasma p-tau biomarkers suggest that they primarily reflect Aβ dysmetabolism. So, they would be highly ef…
View article: Unleashing the potential of UiO-66-NH2 nanozyme: A novel approach to exosomal biomarkers detection in body fluids
Unleashing the potential of UiO-66-NH2 nanozyme: A novel approach to exosomal biomarkers detection in body fluids Open
Exosomes, a subgroup of extracellular vesicles (EVs), are gaining their position as promising tools for diagnostic and treatment purposes. Their widespread application is however hindered by the lack of cost-effective and straightforward m…
View article: Heterogeneous expression of long noncoding RNA RP11-109D20.2: Insights into regulatory gene expression roles in colon cancer.
Heterogeneous expression of long noncoding RNA RP11-109D20.2: Insights into regulatory gene expression roles in colon cancer. Open
Our data revealed that RP11-109D20.2 may have a considerable role in CRC progression. However, further functional analyses are essential to evaluate the probable role of RP11-109D20.2 as a potential diagnostic marker and its …
View article: A novel alkali and thermotolerant protease from Aeromonas spp. retrieved from wastewater
A novel alkali and thermotolerant protease from Aeromonas spp. retrieved from wastewater Open
View article: Hybridized quantum dot, silica, and gold nanoparticles for targeted chemo-radiotherapy in colorectal cancer theranostics
Hybridized quantum dot, silica, and gold nanoparticles for targeted chemo-radiotherapy in colorectal cancer theranostics Open
Multimodal nanoparticles, utilizing quantum dots (QDs), mesoporous silica nanoparticles (MSNs), and gold nanoparticles (Au NPs), offer substantial potential as a smart and targeted drug delivery system for simultaneous cancer therapy and i…
View article: Chitosan/Nanohydroxyapatite/Hydroxyethyl-cellulose-based printable formulations for local alendronate drug delivery in osteoporosis treatment
Chitosan/Nanohydroxyapatite/Hydroxyethyl-cellulose-based printable formulations for local alendronate drug delivery in osteoporosis treatment Open
Osteoporosis is a silent bone disease and a growing health issue. Despite recent progress in diagnosis and treatment, effective therapeutic strategies are still needed. One of the possible solutions is the implantation of engineered drug-r…
View article: Immediate administration of hTERT-MSCs-IDO1-EVs reduces hypoalbuminemia after spinal cord injury.
Immediate administration of hTERT-MSCs-IDO1-EVs reduces hypoalbuminemia after spinal cord injury. Open
Spinal cord injury (SCI) presents challenging and unpredictable neurological recovery. During inflammatory conditions, the amount of serum albumin and nutrition consumption decreases. Currently, it is proposed to measure serum albumin and …
View article: A potent multifunctional ZIF-8 nanoplatform developed for colorectal cancer therapy by triple-delivery of chemo/radio/targeted therapy agents
A potent multifunctional ZIF-8 nanoplatform developed for colorectal cancer therapy by triple-delivery of chemo/radio/targeted therapy agents Open
Background: Multimodal cancer therapy has garnered significant interest due to its ability to target tumor cells from various perspectives.
View article: Introns and Their Therapeutic Applications in Biomedical Researches.
Introns and Their Therapeutic Applications in Biomedical Researches. Open
The intervening sequences of eukaryotic genes have critical functions in genome regulation, as well as in molecular evolution. Here, we summarize recent advances in our understanding of how introns influence genome regulation, as well as t…
View article: Integrating Omics and CRISPR Technology for Identification and Verification of Genomic Safe Harbor Loci in the Chicken Genome
Integrating Omics and CRISPR Technology for Identification and Verification of Genomic Safe Harbor Loci in the Chicken Genome Open
View article: Designing targeted theranostic drug delivery systems based on magnetic mesoporous silica nanoparticles and investigating their anti-cancer effects in vitro
Designing targeted theranostic drug delivery systems based on magnetic mesoporous silica nanoparticles and investigating their anti-cancer effects in vitro Open
هدف: سرطان کولورکتال (CRC)، دومین عامل مرگ و میر در دنیا محسوب میشود و نانوذرات ترانوستیک با قابلیت درمانی و تصویربرداری بهصورت همزمان بهعنوان بسترهای درمانی و تشخیصی در نظر گرفته میشوند. مواد و روشها: در این مطالعه، نانوذرات متخلخل …
View article: Extracellular vesicles and their cells of origin: Open issues in autoimmune diseases
Extracellular vesicles and their cells of origin: Open issues in autoimmune diseases Open
The conventional therapeutic approaches to treat autoimmune diseases through suppressing the immune system, such as steroidal and non-steroidal anti-inflammatory drugs, are not adequately practical. Moreover, these regimens are associated …
View article: Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance
Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance Open
Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology, as it represents a major obstacle to effective cancer treatment. Since tumor cells are highly diverse at genetic, epigenetic, and phenotypic levels,…
View article: Using magnetic mesoporous silica nanoparticles armed with EpCAM aptamer as an efficient platform for specific delivery of 5-fluorouracil to colorectal cancer cells
Using magnetic mesoporous silica nanoparticles armed with EpCAM aptamer as an efficient platform for specific delivery of 5-fluorouracil to colorectal cancer cells Open
Background: Theranostic nanoparticles with both imaging and therapeutic capacities are highly promising in successful diagnosis and treatment of advanced cancers. Methods: Here, we developed magnetic mesoporous silica nanoparticles (MSNs) …
View article: Downregulation of miR-21 as a promising strategy to overcome drug resistance in cancer
Downregulation of miR-21 as a promising strategy to overcome drug resistance in cancer Open
Despite tremendous achievements in the field of targeted cancer therapy, chemotherapy is still the main treatment option, which is challenged by acquired drug resistance. Various microRNAs are involved in developing drug-resistant cells. m…
View article: The effects of ellagic acid and other pomegranate (<i>Punica granatum</i> L.) derivatives on human gastric cancer AGS cells
The effects of ellagic acid and other pomegranate (<i>Punica granatum</i> L.) derivatives on human gastric cancer AGS cells Open
Although surgery with or without (neo)adjuvant chemo/radiotherapy, as the standard treatments, can be suitable therapeutic strategies for gastric cancer, side effects and drug resistance are two main treatment obstacles. It has been discov…
View article: Investigation the effects of vitreous humor on proliferation and dedifferentiation of differentiated NTERA2 cells
Investigation the effects of vitreous humor on proliferation and dedifferentiation of differentiated NTERA2 cells Open
Mammals have a limited capacity to regenerate their tissues and organs. One of the mechanisms associated with natural regeneration is dedifferentiation. Several small molecules such as vitamin C and growth factors could improve reprogrammi…
View article: Improving anti-cancer drug delivery performance of magnetic mesoporous silica nanocarriers for more efficient colorectal cancer therapy
Improving anti-cancer drug delivery performance of magnetic mesoporous silica nanocarriers for more efficient colorectal cancer therapy Open
View article: CCDC 1861390: Experimental Crystal Structure Determination
CCDC 1861390: Experimental Crystal Structure Determination Open
View article: Cynaropicrin Potentiates the Anti-Tumor Effects of Paclitaxel and 5-Fluorouracil on KYSE30 Human Esophageal Carcinoma
Cynaropicrin Potentiates the Anti-Tumor Effects of Paclitaxel and 5-Fluorouracil on KYSE30 Human Esophageal Carcinoma Open
Natural products or their use in combination therapy regimens may reduce side effects of chemotherapy and increase the effectiveness of treatments. The cytotoxic effects of cynaropicrin, a sesquiterpene lactone isolated from Centaurea behe…
View article: Investigating the effects of two novel 4-MMPB analogs as potent lipoxygenase inhibitors for prostate cancer treatment
Investigating the effects of two novel 4-MMPB analogs as potent lipoxygenase inhibitors for prostate cancer treatment Open
Background Lipoxygenases are one of the critical signaling mediators which can be targeted for human prostate cancer (PC) therapy. In this study, 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine (4-MMPB) and its two analogs, 4-…
View article: Investigating the effects of IDO1, PTGS2, and TGF-β1 overexpression on immunomodulatory properties of hTERT-MSCs and their extracellular vesicles
Investigating the effects of IDO1, PTGS2, and TGF-β1 overexpression on immunomodulatory properties of hTERT-MSCs and their extracellular vesicles Open
View article: Novel function of <i>Nanos2</i> in expression of innate immunity genes and its probable roles in maintenance of pluripotency state.
Novel function of <i>Nanos2</i> in expression of innate immunity genes and its probable roles in maintenance of pluripotency state. Open
From our recent findings in line with many others, it can be concluded that Nanos2 acts as a coin with two sides, regulating pluripotency and immunity together which enhances resistance against inflammatory stimuli. Nanos2 could be …
View article: Human Amniotic Fluid Stem Cells: General Characteristics and Potential Therapeutic Applications
Human Amniotic Fluid Stem Cells: General Characteristics and Potential Therapeutic Applications Open
Introduction: Amniotic fluid contains a mixture of different cell types sloughed from the fetal skin, respiratory, alimentary and urogenital tracts, as well as the amnion membrane. As amniotic fluid develops prior to the process of gastrul…
View article: Immunological Window of Myocardial Infarction
Immunological Window of Myocardial Infarction Open
Acute myocardial infarction (MI) describes as an irreversible death of heart muscle which is initiated by a shortage of myocardium oxygen supply and accompanies by a complex of pro- and anti-inflammatory events. During the last decades, in…
View article: Kidney tissue engineering using a well-preserved acellular rat kidney scaffold and mesenchymal stem cells.
Kidney tissue engineering using a well-preserved acellular rat kidney scaffold and mesenchymal stem cells. Open
The aim of this study was to acquire an effective method for preparation of rat decellularized kidney scaffolds capable of supporting proliferation and differentiation of human adipose tissue derived mesenchymal stem cells (AD-MSCs) into k…
View article: Mesenchymal Stem/Stromal Cells Overexpressing CXCR4<sup>R334X</sup> Revealed Enhanced Migration: A Lesson Learned from the Pathogenesis of WHIM Syndrome
Mesenchymal Stem/Stromal Cells Overexpressing CXCR4<sup>R334X</sup> Revealed Enhanced Migration: A Lesson Learned from the Pathogenesis of WHIM Syndrome Open
C-X-C chemokine receptor type 4 (CXCR4), initially recognized as a co-receptor for HIV, contributes to several disorders, including the WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis) syndrome. CXCR4 binds to its ligand …
View article: Design, synthesis and evaluation of PD-L1 peptide antagonists as new anticancer agents for immunotherapy
Design, synthesis and evaluation of PD-L1 peptide antagonists as new anticancer agents for immunotherapy Open
View article: MTA Enhances the Potential of Adipose-Derived Mesenchymal Stem Cells for Dentin–Pulp Complex Regeneration
MTA Enhances the Potential of Adipose-Derived Mesenchymal Stem Cells for Dentin–Pulp Complex Regeneration Open
The aim of the current study was to investigate the effects of mineral trioxide aggregate (MTA) on the proliferation and differentiation of human adipose-derived mesenchymal stem cells (Ad-MSCs) as a surrogate cell source in futuristic ste…