Anupama Priyadarshini
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View article: In vitro and In Vivo FOXO3 dependent induction of fetal hemoglobin
In vitro and In Vivo FOXO3 dependent induction of fetal hemoglobin Open
Background: Induction of fetal hemoglobin (HbF) is a key therapeutic strategy to treat sickle cell disease (SCD). Unfortunately, the only widely used therapy to induce HbF, hydroxyurea (HU), is clinically effective in only half of adults w…
View article: Unveiling the antioxidant potential of Curcuma amada Roxb. leaf essential oil : An in silico and in vitro investigation of major constituents
Unveiling the antioxidant potential of Curcuma amada Roxb. leaf essential oil : An in silico and in vitro investigation of major constituents Open
Elevated levels of human peroxiredoxin 5 (Prdx5), a cytoprotective antioxidant enzyme protects cellular compartments from oxidative damage induced by peroxides. In recent years, essential oils are regarded a viable source of non-toxic anti…
View article: Reviving Seth Chuhimal Ki Talab: Traditional Water Systems and Environmental Sustainability in Nuh, Haryana
Reviving Seth Chuhimal Ki Talab: Traditional Water Systems and Environmental Sustainability in Nuh, Haryana Open
Traditional water bodies for centuries have served as lifelines for communities in India. These water bodies not only offer vital water security but also provide ecological and cultural benefits. Seth Chuhimal ki Talab in Nuh, Haryana, is …
View article: The Role Of Immunostimulants In Improving The Immunity In Autoimmune Diseases
The Role Of Immunostimulants In Improving The Immunity In Autoimmune Diseases Open
The proper functioning of human immune system is essential for organism survival against infectious, toxic and oncogenic agents. Immunomodulators are natural or synthetic materials that regulate the immune system and induce innate and adap…
View article: LONG-TERM RHEOLOGICAL BENEFITS OF GBT021601 IMPROVE PATHOLOGICAL ANGIOGENESIS IN THE SICKLE MOUSE BONE MARROW AND PREVENTS DEVELOPMENT OF HYPERALGESIA.
LONG-TERM RHEOLOGICAL BENEFITS OF GBT021601 IMPROVE PATHOLOGICAL ANGIOGENESIS IN THE SICKLE MOUSE BONE MARROW AND PREVENTS DEVELOPMENT OF HYPERALGESIA. Open
Background: In sickle cell disease (SCD), the abnormal sickle hemoglobin (HbS) on deoxygenation, polymerizes causing repeated vaso-occlusive episodes and hypoxic injury leading to significant morbidity and mortality. Acute pain is the sing…
View article: Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases
Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases Open
The progression of proteinuric kidney diseases is associated with podocyte loss, but the mechanisms underlying this process remain unclear. Podocytes reenter the cell cycle to repair double-stranded DNA breaks. However, unsuccessful repair…
View article: Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2
Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2 Open
Significance Statement The loss of integrity of the glomerular filtration barrier results in proteinuria that is often attributed to podocyte loss. Yet how damaged podocytes are lost remains unknown. Germline loss of murine podocyte-associ…