Ara Nazarian
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View article: Tear Area Predicts Natural History of Rotator Cuff Degeneration: A Retrospective Study of Supraspinatus Tear Progression
Tear Area Predicts Natural History of Rotator Cuff Degeneration: A Retrospective Study of Supraspinatus Tear Progression Open
View article: Impact of Medical and Social Determinants of Health on Survival Following Fall-Induced Hip Fractures: A Retrospective Analysis
Impact of Medical and Social Determinants of Health on Survival Following Fall-Induced Hip Fractures: A Retrospective Analysis Open
Purpose Hip fractures are more than isolated injuries; they can lead to long-term disability, complications, and reduced survival. Managing these outcomes may depend on both medical and socioeconomic factors. This study examines the associ…
View article: Foot Muscle Cross-Sectional Area and Recurrent Falls: A Preliminary MRI-Based Evaluation
Foot Muscle Cross-Sectional Area and Recurrent Falls: A Preliminary MRI-Based Evaluation Open
View article: Detecting Fifth Metatarsal Fractures on Radiographs Through the Lens of Smartphones: The FIXUS AI Algorithm
Detecting Fifth Metatarsal Fractures on Radiographs Through the Lens of Smartphones: The FIXUS AI Algorithm Open
View article: The Development of a Wearable-Based System for Detecting Shaken Baby Syndrome Using Machine Learning Models
The Development of a Wearable-Based System for Detecting Shaken Baby Syndrome Using Machine Learning Models Open
Shaken Baby Syndrome (SBS) is one of the primary causes of fatal head trauma in infants and young children, occurring in about 33 per 100,000 infants annually in the U.S., with mortality rates being between 15% and 38%. Survivors frequentl…
View article: Timing of Chemical Anticoagulant Administration in Spine Trauma and its Impact on VTE, Bleeding, and Mortality: A Systematic Review and Meta-Analysis
Timing of Chemical Anticoagulant Administration in Spine Trauma and its Impact on VTE, Bleeding, and Mortality: A Systematic Review and Meta-Analysis Open
Study Design Systematic review and meta-analysis. Objective To evaluate the timing of anticoagulation in acute spinal trauma, specifically assessing the efficacy and safety of early (<48 hours) vs delayed administration for chemical venous…
View article: Stereophotogrammetry for 3-Dimensional Kinematic Analysis in Rotator Cuff Tears: An Experimental Study Assessing Correlation with Clinical Scores
Stereophotogrammetry for 3-Dimensional Kinematic Analysis in Rotator Cuff Tears: An Experimental Study Assessing Correlation with Clinical Scores Open
Background: Rotator cuff tears (RCTs) are a significant cause of shoulder pain and disability. In clinical practice, assessing a patient’s rotator cuff health status generally includes multiple questionnaire-based clinical scales. Optoelec…
View article: Addressing the growing burden of musculoskeletal diseases in the ageing US population: challenges and innovations
Addressing the growing burden of musculoskeletal diseases in the ageing US population: challenges and innovations Open
The prevalence of musculoskeletal diseases such as osteoarthritis, osteoporosis, sarcopenia, and rheumatoid arthritis is rising sharply with global ageing, increasing disability rates among older adults (aged ≥60 years), diminishing qualit…
View article: Robotic Innovations in Orthopedics: A Growing Landscape, Challenges, and Implications for Care
Robotic Innovations in Orthopedics: A Growing Landscape, Challenges, and Implications for Care Open
This perspective work focuses on the transformative role of robotics in orthopedic surgery, enhancing precision and efficiency. It details the evolution of robotic systems such as ROBODOC, Mako, and Da Vinci, outlining their contributions …
View article: A Meta-Analysis Study to Define Variations in Murine Long Bone Biomechanical Testing
A Meta-Analysis Study to Define Variations in Murine Long Bone Biomechanical Testing Open
A systematic literature search and meta-analysis were performed to evaluate the variability in biomechanical testing of murine long bones, specifically focused on point-bending tests of mice femora. Due to the lack of standardized protocol…
View article: Artificial intelligence demonstrates potential to enhance orthopaedic imaging across multiple modalities: A systematic review
Artificial intelligence demonstrates potential to enhance orthopaedic imaging across multiple modalities: A systematic review Open
Purpose While several artificial intelligence (AI)‐assisted medical imaging applications are reported in the recent orthopaedic literature, comparison of the clinical efficacy and utility of these applications is currently lacking. The aim…
View article: Initiation and progression of rotator cuff tears due to fatigue loading: a cadaveric study
Initiation and progression of rotator cuff tears due to fatigue loading: a cadaveric study Open
In a biomechanical model of RC tears induced by fatigue loading, tear initiation was observed approximately 16 mm posterior to the biceps tendon, positioning it further posterior than previously believed. Alterations to the biomechanical p…
View article: Performance of Natural Language Processing versus International Classification of Diseases Codes in Building Registries for Patients With Fall Injury: Retrospective Analysis
Performance of Natural Language Processing versus International Classification of Diseases Codes in Building Registries for Patients With Fall Injury: Retrospective Analysis Open
Background Standardized registries, such as the International Classification of Diseases ( ICD ) codes, are commonly built using administrative codes assigned to patient encounters. However, patients with fall injury are often coded using …
View article: Comparative analysis of unicortical vs. subchondral locking screws in osteoporotic proximal humerus fractures
Comparative analysis of unicortical vs. subchondral locking screws in osteoporotic proximal humerus fractures Open
View article: Chemical anticoagulant administration within 48 hours of injury significantly lowers the odds of VTEs without increasing bleeding or mortality among patients with spine trauma
Chemical anticoagulant administration within 48 hours of injury significantly lowers the odds of VTEs without increasing bleeding or mortality among patients with spine trauma Open
View article: A computational model that integrates unrestricted callus growth, mechanobiology, and angiogenesis can predict bone healing in rodents
A computational model that integrates unrestricted callus growth, mechanobiology, and angiogenesis can predict bone healing in rodents Open
We present a computational model that integrates mechanobiological regulations, angiogenesis simulations and models natural callus development to simulate bone fracture healing in rodents. The model inputs include atomic force microscopy v…
View article: Assessment of Bacteriophage Pharmacokinetic Parameters After Intra-Articular Delivery in a Rat Prosthetic Joint Infection Model
Assessment of Bacteriophage Pharmacokinetic Parameters After Intra-Articular Delivery in a Rat Prosthetic Joint Infection Model Open
Prosthetic joint infections (PJIs) are a serious complication of orthopedic surgery. Bacteriophage (phage) therapy shows promise as an adjunctive treatment but requires further study, particularly in its pharmacokinetics. Consequently, we …
View article: Arthroscopic Bone Block and Arthroscopic Latarjet for Anterior Shoulder Dislocation—Technical Note with Tricks and Tips for Conversion and Successful Surgery
Arthroscopic Bone Block and Arthroscopic Latarjet for Anterior Shoulder Dislocation—Technical Note with Tricks and Tips for Conversion and Successful Surgery Open
Background: The treatment of patients affected by recurrent anterior shoulder instability has received more attention in the last ten years, focusing on the management of bone loss, which is crucial in predicting postoperative recurrence r…
View article: Characterization of the craniofacial abnormalities of the homozygous G608G progeria mouse model
Characterization of the craniofacial abnormalities of the homozygous G608G progeria mouse model Open
Introduction Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by premature aging, impacting multiple organ systems, including cardiovascular, musculoskeletal, and integumentary. Significant abnormalitie…
View article: Finite element-based evaluation of the supraspinatus tendon biomechanical environment necessitates better clinical management based on tear location and thickness
Finite element-based evaluation of the supraspinatus tendon biomechanical environment necessitates better clinical management based on tear location and thickness Open
View article: Bacteriophage Dosing and Its Effect on Bacterial Growth Suppression in a <i>Staphylococcus epidermidis</i> Model: An <i>In Vitro</i> Study
Bacteriophage Dosing and Its Effect on Bacterial Growth Suppression in a <i>Staphylococcus epidermidis</i> Model: An <i>In Vitro</i> Study Open
Our findings suggest lower, not higher, phage dosing is associated with greater bacterial persistence. Our study helps inform the dosing and delivery of this alternative form of antibiosis.
View article: Disparities in Rotator Cuff Tear Progression Definitions and Rates
Disparities in Rotator Cuff Tear Progression Definitions and Rates Open
Background: While rotator cuff tears are prevalent in the general population, the natural history of this disease is unclear. Understanding rotator cuff tear progression is crucial for refining surgical indications and evaluating the neces…
View article: Effect of Glenohumeral Abduction on Supraspinatus Tendon Strain: A Cadaveric Study
Effect of Glenohumeral Abduction on Supraspinatus Tendon Strain: A Cadaveric Study Open
Objectives Rotator cuff tears are among the most common causes of shoulder pain and loss of function in adults. The supraspinatus tendon plays a crucial role in shoulder abduction, where a better understanding of the mechanical environment…
View article: Stimulation of fracture mineralization by salt-inducible kinase inhibitors
Stimulation of fracture mineralization by salt-inducible kinase inhibitors Open
Introduction Over 6.8 million fractures occur annually in the US, with 10% experiencing delayed- or non-union. Anabolic therapeutics like PTH analogs stimulate fracture repair, and small molecule salt inducible kinase (SIK) inhibitors mimi…
View article: Detection and Localization of Spine Disorders from Plain Radiography
Detection and Localization of Spine Disorders from Plain Radiography Open
View article: Computed tomography-based structural rigidity analysis can assess tumor- and treatment-induced changes in rat bones with metastatic lesions
Computed tomography-based structural rigidity analysis can assess tumor- and treatment-induced changes in rat bones with metastatic lesions Open
Background Breast cancer (BrCa) is a predominant malignancy, with metastasis occurring in one in eight patients, nearly half of which target the bone, leading to serious complications such as pain, fractures, and compromised mobility. Stru…
View article: Excellent accuracy of magnetic resonance imaging for diagnosis of discoid meniscus tears: A systematic review and meta‐analysis
Excellent accuracy of magnetic resonance imaging for diagnosis of discoid meniscus tears: A systematic review and meta‐analysis Open
Purpose The discoid meniscus (DM) is distinguished by its thickened, disc‐shaped formation, which extends over the tibial plateau. The likelihood of developing osteoarthritis escalates if a DM tear remains undiagnosed and untreated. While …
View article: Proximal femur fracture detection on plain radiography via feature pyramid networks
Proximal femur fracture detection on plain radiography via feature pyramid networks Open
Hip fractures exceed 250,000 cases annually in the United States, with the worldwide incidence projected to increase by 240–310% by 2050. Hip fractures are predominantly diagnosed by radiologist review of radiographs. In this study, we dev…
View article: Metaverse, virtual reality and augmented reality in total shoulder arthroplasty: a systematic review
Metaverse, virtual reality and augmented reality in total shoulder arthroplasty: a systematic review Open
View article: Sociodemographic and Lifestyle Risk Factors Associated with Fragility Hip Fractures: A Systematic Review and Meta-Analysis
Sociodemographic and Lifestyle Risk Factors Associated with Fragility Hip Fractures: A Systematic Review and Meta-Analysis Open
Hip fractures inflict heightened morbidity and mortality upon older adults. Although previous studies have explored the impact of individual demographic factors on hip fracture risk, a comprehensive review can help reconcile disparities am…