Aracely Castillo-Venzor
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View article: Origin and segregation of the human germline
Origin and segregation of the human germline Open
Human germline–soma segregation occurs during weeks 2–3 in gastrulating embryos. Although direct studies are hindered, here, we investigate the dynamics of human primordial germ cell (PGCs) specification using in vitro models with temporal…
View article: Origin and segregation of the human germline
Origin and segregation of the human germline Open
Human germline-soma segregation occurs during weeks 2-3 in gastrulating embryos. While direct studies are hindered, here we investigate the dynamics of human primordial germ cell (PGCs) specification using in vitro models with temporally r…
View article: Sequential enhancer state remodelling defines human germline competence and specification
Sequential enhancer state remodelling defines human germline competence and specification Open
View article: Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells
Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells Open
Rabbit embryos develop as bilaminar discs at gastrulation as in humans and most other mammals, whereas rodents develop as egg cylinders. Primordial germ cells (PGCs) appear to originate during gastrulation according to many systematic stud…
View article: Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression Open
View article: Mutational synergy coordinately remodels chromatin accessibility, enhancer landscape and 3-Dimensional DNA topology to alter gene expression during leukemia induction
Mutational synergy coordinately remodels chromatin accessibility, enhancer landscape and 3-Dimensional DNA topology to alter gene expression during leukemia induction Open
Altered transcription is a cardinal feature of acute myeloid leukemia (AML), however, exactly how mutations synergize to remodel the epigenetic landscape and rewire 3-Dimensional (3-D) DNA topology is unknown. Here we apply an integrated g…