Aram Arshadi
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View article: Abstract B024: Advancing precision medicine: A prospective feasibility study integrating <i>ex vivo</i> drug testing and genomic profiling to improve outcomes in children and adults with advanced cancers
Abstract B024: Advancing precision medicine: A prospective feasibility study integrating <i>ex vivo</i> drug testing and genomic profiling to improve outcomes in children and adults with advanced cancers Open
Background: Despite advancements in precision oncology, only a minor subset of patients can be matched with effective targeted therapy, and even fewer experience sustained benefits. This is partly because current approaches, such as genomi…
Generative Modelling of Oncogene-carrying Extrachromosomal Circular DNA Biogenesis and Dynamics in Cells Open
Extrachromosomal circular DNAs (ecDNA) are focal gene amplifications frequently associated with cancer development and often indicating a poor prognosis. To understand the early dynamics of oncogene-carrying ecDNAs, we previously developed…
A novel method for the isolation of single cells mimicking circulating tumour cells adhered on Smart Bio Surface slides by Laser Capture Microdissection Open
In recent years, the importance of isolating single cells from blood circulation for several applications, such as non-invasive tumour diagnosis, the monitoring of minimal residual disease, and the analysis of circulating fetal cells for p…
VEGFA Status as a Predictive Marker of Therapy Outcome in Metastatic Gastric Cancer Patients Following Ramucirumab-Based Treatment Open
Metastatic gastric cancer (mGC) often has a poor prognosis and may benefit from a few targeted therapies. Ramucirumab-based anti-angiogenic therapy targeting the VEGFR2 represents a milestone in the second-line treatment of mGC. Several st…
Advancements in Focal Amplification Detection in Tumor/Liquid Biopsies and Emerging Clinical Applications Open
Focal amplifications (FAs) are crucial in cancer research due to their significant diagnostic, prognostic, and therapeutic implications. FAs manifest in various forms, such as episomes, double minute chromosomes, and homogeneously staining…