Aram Halimi
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Exploring the genetic basis of essential hypertension: association with AGT gene variants in an Iranian population Open
This study provides evidence for the involvement of AGT gene variants and haplotypes in the pathogenesis of EH in the Iranian population. These findings highlight the importance of considering genetic factors in the development and managem…
Stage-specific and regional trends in prostate cancer incidence in Kazakhstan, 2005–2024 Open
Background Prostate cancer is a leading malignancy among men globally and continues to be a growing concern in Kazakhstan, where evidence regarding its long-term epidemiological trends is limited. Objectives This study seeks to assess nati…
Homicide Mortality in Iran, 2006–2023: Gender Gaps, Regional Disparities, and the Predominance of Firearms Open
Background: Homicide is a critical public health concern with significant social, economic, and psychological implications. Despite previous research in Iran, there has been no comprehensive analysis of nationwide homicide trends over the …
A spatiotemporal analysis of incidence and mortality rate due to falls in Iran from 2010 to 2019 Open
Population aging in Iran is a health-treatment challenge. Falling is one of the consequences of this challenge. The southern and western provinces allocate the highest age-standardized incidence and mortality rates. Ensuring equitable acce…
Prevalence of Intimate Partner Violence Against Women and Its Contributing Factors in Tehran, Iran Open
Given the high prevalence of intimate partner violence, especially during the coronavirus disease 2019 pandemic, and its association with factors such as education, addiction, and marriage characteristics, these findings highlight the urge…
Therapeutic Efficacy of Intermittent Ketogenesis in Modulating Adenosine Metabolism, Immune Response, and Seizure Severity in Refractory Temporal Lobe Epilepsy: A Pilot Human Study Open
Temporal lobe epilepsy (TLE) is a common neurological disorder characterized by recurrent seizures originating in the temporal lobe, often affecting patients' physical, cognitive, and social well-being. Despite the availability of antiseiz…
Prostate cancer incidence and mortality linked to metalworking fluid exposure: a systematic review and meta-analysis Open
Background Prostate cancer is the second most diagnosed cancer in men globally, with high prevalence in North America, Europe, and Australia. Occupational exposures, including metalworking fluids (MWFs), have emerged as a potential risk fa…
Ubiquitin-specific peptidases in lymphoma: a path to novel therapeutics Open
Background Ubiquitin-specific peptidases (USPs), also known as deubiquitinating enzymes (DUBs), play a crucial role in maintaining cellular homeostasis by selectively removing ubiquitin molecules from targeted proteins. This process affect…
Aspartame Consumption and Cancer Risk: A Systematic Review and Meta-Analysis Protocol Open
Background: Aspartame, a widely used artificial sweetener, has been under scrutiny for its potential carcinogenic effects. Although early studies raised concerns about its link to cancer, particularly in animal models, more recent human st…
The Effect of COVID-19 Lockdown Among Adolescents with Type 1 Diabetes: A Systematic Review and Meta-Analysis Open
Objective: The aim of this study was to assess how the lockdown of the COVID-19 pandemic had affected the glycaemic control of adolescents aged 10-19 with type 1 diabetes. Methods: A comprehensive search of literature was performed in PubM…
The Study of Exposure to Occupational Carcinogens in Iran: A Scoping Review Open
Background: Occupational exposure to carcinogens is a significant issue in occupational health and public welfare, with carcinogens encompassing a wide range of substances such as chemicals, metals, dust particles, and organic materials. T…
ChecKAP: A Checklist for Reporting a Knowledge, Attitude, and Practice (KAP) Study Open
ChecKAP assesses the inherent complexity of KAP research methods and ensures consistent reporting. It fills an important gap in the KAP research literature and serves a dual purpose. First, it acts as a quality assessment tool for reviewer…
Prostate Cancer Incidence and Mortality Linked to Metalworking Fluid Exposure: A Systematic Review and Meta-Analysis Open
Introduction: Prostate cancer is a significant health concern, and occupational exposures, including metalworking fluid (MWF) exposure, have been implicated as potential risk factors. This protocol outlines a systematic review and meta-ana…
View article: Illness-related fatigue and its association with quality of life among people with chronic obstructive pulmonary disease: A cross-sectional survey from Jordan
Illness-related fatigue and its association with quality of life among people with chronic obstructive pulmonary disease: A cross-sectional survey from Jordan Open
Background & Aim: Fatigue is a commonly reported issue in individuals with chronic obstructive pulmonary disease (COPD), often overlooked or inadequately addressed in Jordan and globally. This study aimed to assess illness-related fatigue …
Investigating the Health-related Quality of Life in Hepatitis C Patients with Liver Cirrhosis Using Oral Antivirals, Before and after the Treatment Open
Objectives: Liver Cirrhosis is a debilitating chronic complication of many liver diseases including hepatitis C virus infection. Oral treatment of anti-viral infection can have effect alleviation this complication. The present study was co…
Prevalence of Asthma among Children and Adolescents in WHO's Eastern Mediterranean Region: A Meta-Analysis of Over 0.5 Million Participants Open
Objective: This study aims to evaluate the epidemiology of asthma among children and adolescents in the Eastern Mediterranean Region (EMRO). Methods: Exhaustive searches were conducted across databases, including PubMed, Scopus, Web of Kno…
Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer: A systematic review Open
BACKGROUND Colorectal cancer (CRC) is the third most frequent and the second most fatal cancer. The search for more effective drugs to treat this disease is ongoing. A better understanding of the mechanisms of CRC development and progressi…
Prevalence of Undiagnosed Attention Deficit Hyperactivity Disorder (ADHD) Symptoms in the Young Adult Population of the United Arab Emirates: A National Cross-Sectional Study Open
Background Attention deficit hyperactivity disorder (ADHD), a globally prevalent behavioural disorder, remains underdiagnosed, particularly among adults. This issue is exacerbated in the Arab region due to stigma and insufficient healthcar…
The Study of Exposure to Isophorone and the Risk of Getting Cancer: A Systematic Review and Meta-analysis Protocol Open
Background: This protocol recommends ways to conduct a systematic review and meta-analysis on the association between isophorone exposure and cancer risk. Methods: This study will follow the Preferred Reporting Items for Systematic Reviews…
The Role of Ubiquitin-specific Peptidases in Colorectal Cancer: A Systematic Review Protocol Open
Background: This systematic review aims to comprehensively assess and synthesize the current body of evidence regarding the role of ubiquitin-specific peptidases in colorectal cancer. Methods: This protocol adhered to the guidelines outlin…
View article: The impact of cultural healthcare practices on Children’s health in the United Arab Emirates: a qualitative study of traditional remedies and implications
The impact of cultural healthcare practices on Children’s health in the United Arab Emirates: a qualitative study of traditional remedies and implications Open
Aim This qualitative study investigates the impact of cultural practices on children’s health in the United Arab Emirates (UAE) by examining the use of traditional remedies and home treatments by mothers. Methods Twenty-five participants, …
The Role of Cobalt Exposure in the Incidence of Cancer: A Systematic Review and Meta-Analysis Protocol Open
Background: Cobalt, a versatile transition metal, has widespread industrial applications, but its potential link to cancer has raised concerns. This systematic review and meta-analysis protocol aims to investigate the relationship between …
Red Meat Intake and Risk of Leukemia: A Protocol of Systematic Review and Meta-Analysis Open
Background: The intricate interplay of risk factors and their modifying effects on health outcomes, known as effect modification, remains a critical and complex phenomenon in epidemiological research. In this study, we rigorously explore t…